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dc.contributor.authorBriem, Eirikur
dc.contributor.authorBudkova, Zuzana
dc.contributor.authorSigurdardottir, Anna Karen
dc.contributor.authorHilmarsdottir, Bylgja
dc.contributor.authorKricker, Jennifer
dc.contributor.authorTimp, Winston
dc.contributor.authorMagnusson, Magnus Karl
dc.contributor.authorTraustadottir, Gunnhildur Asta
dc.contributor.authorGudjonsson, Thorarinn
dc.date.accessioned2019-04-12T14:21:08Z
dc.date.available2019-04-12T14:21:08Z
dc.date.issued2019-01-01
dc.date.submitted2019-04
dc.identifier.citationMiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasin. 2019,en_US
dc.identifier.issn1872-6356
dc.identifier.pmid30508578
dc.identifier.doi10.1016/j.mod.2018.11.002
dc.identifier.urihttp://hdl.handle.net/2336/620871
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractMicroRNAs regulate developmental events such as branching morphogenesis, epithelial to mesenchymal transition (EMT) and its reverse process mesenchymal to epithelial transition (MET). In this study, we performed small RNA sequencing of a breast epithelial progenitor cell line (D492), and its mesenchymal derivative (D492M) cultured in three-dimensional microenvironment. Among the most downregulated miRNAs in D492M was miR-203a, a miRNA that plays an important role in epithelial differentiation. Increased expression of miR-203a was seen in D492, concomitant with increased complexity of branching. When miR-203a was overexpressed in D492M, a partial reversion towards epithelial phenotype was seen. Gene expression analysis of D492M and D492Men_US
dc.description.sponsorshipLandspitali University Hospital Science Fund University of Iceland Research Fund Icelandic Science and Technology Policy - Grant of Excellenceen_US
dc.language.isoenen_US
dc.publisherElsevier Scienceen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0925477318300972en_US
dc.subjectGenen_US
dc.subject.meshMorphogenesisen_US
dc.titleMiR-203a is differentially expressed during branching morphogenesis and EMT in breast progenitor cells and is a repressor of peroxidasin.en_US
dc.typeArticleen_US
dc.contributor.department1 Stem Cell Research Unit, Biomedical Center, Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Iceland, Iceland. 2 Stem Cell Research Unit, Biomedical Center, Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Iceland, Iceland; Department of Tumor Biology, The Norwegian Radium Hospital, Oslo, Norway. 3 Department of Biomedical Engineering, Johns Hopkins University, USA. 4 Department of Laboratory Hematology, Landspitali - University Hospital, Iceland; Department of Pharmacology and Toxicology, Faculty of Medicine, School of Health Sciences, University of Iceland, Iceland. 5 Stem Cell Research Unit, Biomedical Center, Department of Anatomy, Faculty of Medicine, School of Health Sciences, University of Iceland, Iceland; Department of Laboratory Hematology, Landspitali - University Hospital, Iceland. Electronic address: tgudjons@hi.is.en_US
dc.identifier.journalMechanisms of developmenten_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeHEM12
dc.source.journaltitleMechanisms of development


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