A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
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AuthorsKristjansson, Ragnar P
Davidsson, Olafur B
Sigurdsson, Jon K
Jensson, Brynjar O
Arthur, Joseph G
Arnadottir, Gudny A
Halldorsson, Bjarni V
Halldorsson, Gisli H
Stefansson, Olafur A
Oskarsson, Gudjon R
Deaton, Aimee M
Eyjolfsson, Gudmundur I
Onundarson, Pall T
Ludviksson, Bjorn R
Olafsdottir, Thorunn A
Magnusson, Olafur Th
Bjornsdottir, Unnur S
Norddahl, Gudmundur L
Gudbjartsson, Daniel F
MetadataShow full item record
CitationA loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis. 2019, 51(2):267-276 Nat Genet
AbstractNasal polyps (NP) are lesions on the nasal and paranasal sinus mucosa and are a risk factor for chronic rhinosinusitis (CRS). We performed genome-wide association studies on NP and CRS in Iceland and the UK (using UK Biobank data) with 4,366 NP cases, 5,608 CRS cases, and >700,000 controls. We found 10 markers associated with NP and 2 with CRS. We also tested 210 markers reported to associate with eosinophil count, yielding 17 additional NP associations. Of the 27 NP signals, 7 associate with CRS and 13 with asthma. Most notably, a missense variant in ALOX15 that causes a p.Thr560Met alteration in arachidonate 15-lipoxygenase (15-LO) confers large genome-wide significant protection against NP (P = 8.0 × 10
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