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dc.contributor.authorFlexeder, Claudia
dc.contributor.authorZock, Jan-Paul
dc.contributor.authorJarvis, Deborah
dc.contributor.authorVerlato, Giuseppe
dc.contributor.authorOlivieri, Mario
dc.contributor.authorBenke, Geza
dc.contributor.authorAbramson, Michael J
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorSvanes, Cecilie
dc.contributor.authorTorén, Kjell
dc.contributor.authorNowak, Dennis
dc.contributor.authorJõgi, Rain
dc.contributor.authorMartinez-Moratalla, Jesús
dc.contributor.authorDemoly, Pascal
dc.contributor.authorJanson, Christer
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorBono, Roberto
dc.contributor.authorHolm, Mathias
dc.contributor.authorFranklin, Karl A
dc.contributor.authorGarcia-Aymerich, Judith
dc.contributor.authorSiroux, Valérie
dc.contributor.authorLeynaert, Bénédicte
dc.contributor.authorDorado Arenas, Sandra
dc.contributor.authorCorsico, Angelo Guido
dc.contributor.authorPereira-Vega, Antonio
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorUrrutia Landa, Isabel
dc.contributor.authorSchulz, Holger
dc.contributor.authorHeinrich, Joachim
dc.date.accessioned2019-05-03T13:34:26Z
dc.date.available2019-05-03T13:34:26Z
dc.date.issued2019-02-14
dc.date.submitted2019
dc.identifier.citationSecond-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.2019, 20(1): 33 Respir Resen_US
dc.identifier.issn1465-993X
dc.identifier.pmid30764884
dc.identifier.doi10.1186/s12931-019-0996-z
dc.identifier.urihttp://hdl.handle.net/2336/620886
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractEarly life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years. We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Associations of SHS exposure with respiratory health (asthma symptom score, asthma, chronic bronchitis, COPD) were analysed using generalised linear mixed-effects models adjusted for confounding factors (including sex, age, smoking status, socioeconomic status and allergic sensitisation). Linear mixed-effects models with additional adjustment for height were used to assess the relationships between SHS exposure and lung function levels and decline. Reported exposure to SHS decreased in all 26 study centres over time. The prevalence of SHS exposure was 38.7% at baseline (1990-1994) and 7.1% after the 20-year follow-up (2008-2011). On average 2.4% of the study participants were not exposed at the first, but were exposed at the third examination. An increase in SHS exposure over time was associated with doctor-diagnosed asthma (odds ratio (OR): 2.7; 95% confidence interval (95%-CI): 1.2-5.9), chronic bronchitis (OR: 4.8; 95%-CI: 1.6-15.0), asthma symptom score (count ratio (CR): 1.9; 95%-CI: 1.2-2.9) and dyspnoea (OR: 2.7; 95%-CI: 1.1-6.7) compared to never exposed to SHS. Associations between increase in SHS exposure and incidence of COPD (OR: 2.0; 95%-CI: 0.6-6.0) or lung function (β: - 49 ml; 95%-CI: -132, 35 for FEV Exposure to second-hand smoke may lead to respiratory symptoms, but this is not accompanied by lung function changes.en_US
dc.description.sponsorshipAustralia: Asthma Foundation of Victoria Belgium: Belgian Science Policy Office Estonia: Estonian Science Foundation 1088 France: Ministere de la Sante France: Glaxo France France: Insitut Pneumologique d'Aquitaine France: Contrat de Plan Etat-Region Languedoc-Rousillon France: CNMATS France: CNMRT 90MR/10, 91AF/6 France: Ministre delegue de la sante France: RNSP, France GSF Germany: Bundesminister fur Forschung und Technologie Italy: Ministero dell'Universita e della Ricerca Scientifica e Tecnologica Italy: CNR Italy: Regione Veneto grant RSF 381/05.93 Norway: Norwegian Research Council 101422/310 214123 Spain: Fondo de Investigacion Sanitaria 91/0016-060-05/E 92/0319 93/0393 PS09/02457 PS09/00716 09/01511 PS09/02185 PS09/03190 Spain: Hospital General de Albacete Spain: Hospital General Juan Ramon Jimenez Spain: Direccion Regional de Salud Publica (Consejeria de Sanidad del Principado de Asturias) Spain: CIRIT 1997 SGR 00079 Spain: Servicio Andaluz de Salud Sweden: The Swedish Medical Research Council Sweden: Swedish Heart Lung Foundation Sweden: Swedish Association against Asthma and Allergy Switzerland: Swiss national Science Foundation 4026-28099 UK: National Asthma Campaign UK: British Lung Foundation UK: Department of Health UK: South Thames Regional Health Authority European Commission Australia: National Health and Medical Research Council Belgium: Antwerp: Fund for Scientific Research G.0402.00 Estonia: Tartu Estonian Science Foundation 4350 France: Bordeaux: Institut Pneumologique d'Aquitaine Grenoble: Programme Hospitalier de Recherche Clinique -Direction de la Recherche Clinique (DRC) de Grenoble 2000 2610 Montpellier: Programme Hospitalier de Recherche Clinique -DRC de Grenoble 2000 2610 Paris: Ministere de l'Emploi et de la Solidarite Paris: Direction Generale de la Sante Paris: Union Chimique Belge-Pharma (France) Paris: Aventis (France) Paris: Glaxo France Paris: Programme Hospitalier de Recherche Clinique -DRC de Grenoble 2000 2610 Germany: Erfurt: GSF -National Research Centre for Environment and Health Germany: Erfurt: Deutsche Forschungsgemeinschaft FR1526/1-1 Belgium: Antwerp: University of Antwerp Belgium: Antwerp: Flemish Health Ministry Grenoble: Ministere de l'Emploi et de la Solidarite Grenoble: Direction Generale de la Sante Grenoble: Centre Hospitalier Universitaire (CHU) de Grenoble Grenoble: Comite des Maladies Respiratoires de l'Isere Montpellier: Ministry of Health Montpellier: Direction de la Recherche Clinique Montpellier: CHU de Grenoble Montpellier: Ministere de l'Emploiet de la Solidarite Montpellier: Direction Generale de la Sante Montpellier: Aventis (France) Montpellier: Direction Regionale des Affaires Sanitaires et Sociales Languedoc-Roussillon Hamburg: GSF -National Research Centre for Environment and Health Hamburg: Deutsche Forschungsgemeinschaft MA 711/4-1 Iceland: Reykjavik: Icelandic Research Council Iceland: Reykjavik: Icelandic University Hospital Fund Italy: Pavia: GlaxoSmithKline Italy Italy: Pavia: Italian Ministry of University and Scientific and Technological Research (MURST) Italy: Pavia: Local University Funding for Research 1998 Italy: Pavia: Local University Funding for Research 1999 Turin: Azienda Sanitaria Locale 4 Regione Piemonte (Italy) Turin: Azienda Ospedaliera Centro Traumatologico Ospedaliero/Centro Traumatologico Ortopedico-Istituto Clinico Ortopedico Regina Maria Adelaide Regione Piemonte Verona: Ministero dell'Universita'e della Ricerca Scientifica (MURST) Verona: Glaxo Wellcome spa Norway: Bergen: Norwegian Asthma and Allergy Association Norway: Bergen: Glaxo Wellcome AS Norway: Bergen: Norway Research Fund Spain: Fondo de Investigacion Santarias 97/0035-01 99/0034-01 99/0034 02 Spain: HospitalUniversitario de Albacete Spain: Consejeria deSanidad Barcelona: Sociedad Espanola de Neumologi'a y Cirugi'a Toracica Barcelona: Public Health Service R01 HL62633-01 Barcelona: Fondo de Investigaciones Santarias 97/0035-01 99/0034-01 99/0034-02 Barcelona: Consell Interdepartamentalde Recerca i Innovacio' Tecnolo'gica 1999SGR 00241 Barcelona: Instituto de Salud Carlos III Red deCentros de Epidemiologi'a y Salud Pu' blica C03/09 Redde Basesmoleculares y fisiolo'gicas de lasEnfermedadesRespiratorias C03/011 Red de Grupos Infancia y Medio Ambiente G03/176 Huelva: Fondo de Investigaciones Santarias 97/0035-01 99/0034-01 99/0034-02 Galdakao: Basque Health Department Oviedo: Fondo de Investigaciones Sanitaria 99/0034-01 99/0034-02 97/0035-02 97/0035 99/0034-04 99/0034-06 99/350 99/0034--07 Oviedo: European Commission EU-PEAL PL01237 Oviedo: Generalitat de Catalunya CIRIT 1999 SGR 00214 Oviedo: Hospital Universitario de Albacete Oviedo: Sociedad Espanola de Neumologia y Cirugia Toracica SEPAR R01 HL62633-01 Oviedo: Red de Centros de Epidemiologia y Salud Publica C03/09 Oviedo: Red de Bases moleculares y fisiologicas de las Enfermedades Respiratorias C03/011 Oviedo: Red de Grupos Infancia y Medio Ambiente 97/0035-01 99/0034-01 99/0034-02 G03/176 Sweden: Goteborg: Swedish Heart Lung Foundation Sweden: Umea: Swedish Heart Lung Foundation Sweden: Uppsala: Swedish Heart Lung Foundation Sweden: Goteborg: Swedish Foundation for Health Care Sciences and Allergy Research Sweden: Umea: Swedish Foundation for Health Care Sciences and Allergy Research Sweden: Uppsala: Swedish Foundation for Health Care Sciences and Allergy Research Sweden: Goteborg: Swedish Asthma and Allergy Foundation Sweden: Umea: Swedish Asthma and Allergy Foundation Sweden: Uppsala: Swedish Asthma and Allergy Foundation Sweden: Goteborg: Swedish Cancer and Allergy Foundation Sweden: Umea: Swedish Cancer and Allergy Foundation Sweden: Uppsala: Swedish Cancer and Allergy Foundation Sweden: Goteborg: Swedish Council for Working Life and Social Research (FAS) Sweden: Umea: Swedish Council for Working Life and Social Research (FAS) Sweden: Uppsala: Swedish Council for Working Life and Social Research (FAS) Switzerland: Basel: Swiss National Science Foundation Switzerland: Basel: Swiss Federal Office for Education and Science Switzerland: Basel: Swiss National Accident Insurance Fund UK: Ipswich: Asthma UK UK: Norwich: Asthma UK Australia: National Health & Medical Research Council Belgium: Antwerp South, Antwerp City: Research Foundation Flanders (FWO) G.0.410.08. N.10 Estonia: Tartu: Estonian Ministry of Education SF0180060s09 France: Programme Hospitalier de Recherche Clinique (PHRC) national 2010 Bordeaux: INSERM U897 Universite Bordeaux segalen Grenoble: Comitee Scientifique AGIRadom 2011 Paris: Agence Nationale de la Sante Paris: Region Ile de France Paris: domaine d'interet majeur (DIM) Germany: Erfurt: German Research Foundation HE 3294/10-1 Hamburg: German Research Foundation MA 711/6-1 262/7-1 Iceland: Reykjavik: The Landspitali University Hospital Research Fund Iceland: Reykjavik: University of Iceland Research Fund Iceland: Reykjavik: ResMed Foundation, California, USA Iceland: Reykjavik: Orkuveita Reykjavikur (Geothermal plant) Iceland: Reykjavik: Vegageroin (The Icelandic Road Administration (ICERA) Italy: Italian Ministry of Health Italy: Chiesi Farmaceutici SpA Italy: Cariverona foundation Italy: Education Ministry (MIUR) Norway: Western Norway Regional Health Authorities 911631 Norway: Bergen Medical Research Foundation Spain: Sociedad Espanola de Neumologia y Cirurgia Toracica SEPAR 1001/2010 Barcelona: Fondo de Investigacion Sanitaria FIS PS09/00716 Galdakao: Fondo de Investigacion Sanitaria FIS 09/01511 Huelva: Fondo de Investigacion Sanitaria FIS PS09/02185 Huelva: Servicio Andaluz de Salud Oviedo: Fondo de Investigacion Sanitaria FIS PS09/03190 Sweden: Swedish Heart and Lung Foundation Sweden: Swedish Asthma and Allergy Association Sweden: Swedish Association against Lung and Heart Disease Sweden: Swedish Research Council for health, working life and welfare (FORTE) Goteborg: Swedish Council for Working life and Social Research Umea: Vasterbotten Country Council ALF grant Switzerland: The Swiss National Science Foundation 33CSCO134276/1 33CSCO-108796 3247BO-104283 3247BO-104288 3247BO-104284 3247-065896 3100-059302 3200-052720 3200-042532 4026-028099 Switzerland: Federal office for forest, environment and landscape Switzerland: Federal Office of Public Health Switzerland: Federal Office of Roads and Transport Switzerland: canton's government of Aargan Switzerland: canton's government of Basel-Stadt Switzerland: canton's government of Basel-Land Switzerland: canton's government of Geneva Switzerland: canton's government of Luzern Switzerland: canton's government of Ticino Switzerland: canton's government of Valais Switzerland: canton's government of Zurich Switzerland: Swiss Lung League Switzerland: canton's Lung League of Basel Stadt/Basel Switzerland: canton's Lung League of Landschaft Switzerland: canton's Lung League of Geneva Switzerland: canton's Lung League of Ticino Switzerland: canton's Lung League of Valais Switzerland: canton's Lung League of Zurich Switzerland: SUVA Switzerland: Freiwillige Akademische Gesellschaft Switzerland: UBS Wealth Foundation Switzerland: Talecris Biotherapeutics GmbH Switzerland: Abbott Diagnostics Switzerland: European Commission 018996 Switzerland: Wellcome Trust WT 084703MA UK: Medical Research Council (MRC) of the National Institute for Health Research through the Primary Care Research Network Belgium: National Fund for Scientific Research Grenoble: Ministry of Health Norway: Bergen: Norwegian Research Council Australia: Allen and Hanbury'sen_US
dc.language.isoenen_US
dc.publisherBioMed Centralen_US
dc.relation.urlhttps://link.springer.com/article/10.1186/s12931-019-0996-zen_US
dc.subjectAdultsen_US
dc.subjectAsthmaen_US
dc.subjectBronchitisen_US
dc.subjectECRHSen_US
dc.subjectLung functionen_US
dc.subjectRespiratory symptomsen_US
dc.subjectSmokingen_US
dc.subjectÓbeinar reykingaren_US
dc.subjectReykingaren_US
dc.subjectÖndunarfærasjúkdómaren_US
dc.subject.otherTobacco Smoke Pollutionen_US
dc.subject.otherRespiratory Tract Diseasesen_US
dc.titleSecond-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.en_US
dc.typeArticleen_US
dc.contributor.department1 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany. claudia.flexeder@helmholtz-muenchen.de. 2 Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. 3 Universitat Pompeu Fabra (UPF), Barcelona, Spain. 4 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 5 MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. 6 National Heart and Lung Institute, Imperial College London, London, UK. 7 Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, Verona, Italy. 8 University Hospital of Verona, Verona, Italy. 9 School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. 10 Department of Public Health, Aarhus University, Aarhus, Denmark. 11 Centre for International Health, University of Bergen, Bergen, Norway. 12 Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway. 13 Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. 14 Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich (LMU), Munich, Germany. 15 Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Munich, Germany. 16 Lung Clinic, Tartu University Clinics, Tartu, Estonia. 17 Servicio de Neumología del Complejo, Servicio de Salud de Castilla - La Mancha (SESCAM), Hospitalario Universitario de Albacete, Albacete, Spain. 18 Facultad de Medicina de Albacete, Universidad de Castilla - La Mancha, Albacete, Spain. 19 Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France. 20 Inserm, Sorbonne Université, Equipe EPAR - IPLESP, Paris, France. 21 Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden. 22 Department of Sleep, Landspitali National University Hospital of Iceland, Reykjavik, Iceland. 23 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 24 Department of Public Health and Pediatrics, University of Turin, Turin, Italy. 25 Department of Surgical and Perioperative Sciences, Surgery, Umea University, Umea, Sweden. 26 Institute for Advanced Biosciences, UGA-Inserm U1209-CNRS UMR 5309, Joint Research Center, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Site Santé - Allée des Alpes, 38700 La Tronche, Grenoble, France. 27 Inserm, UMR 1152, Pathophysiology and Epidemiology of Respiratory Diseases, Paris, France, UMR 1152, University Paris Diderot Paris, Paris, France. 28 Pulmonology Department, Galdakao-Usansolo Hospital, Galdakao, Biscay, Spain. 29 Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation, Pavia, Italy. 30 Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. 31 Respiratory and Allergy Clinical Unit, Universitary Hospitalary Complex, Huelva, Spain. 32 Swiss Tropical and Public Health Institute, Basel, Switzerland. 33 Department of Public Health, University of Basel, Basel, Switzerland. 34 Pulmonary Department, Hospital Galdakao, Galdakao, Biscay, Spain. 35 Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany. 36 Allergy and Lung Health Unit, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.en_US
dc.identifier.journalRespiratory researchen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodePAD12
dc.source.journaltitleRespiratory research
refterms.dateFOA2019-05-03T13:34:26Z


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