A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples.
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Authors
Sutherland, KateKeenan, Brendan T
Bittencourt, Lia
Chen, Ning-Hung
Gislason, Thorarinn
Leinwand, Sarah
Magalang, Ulysses J
Maislin, Greg
Mazzotti, Diego R
McArdle, Nigel
Mindel, Jesse
Pack, Allan I
Penzel, Thomas
Singh, Bhajan
Tufik, Sergio
Schwab, Richard J
Cistulli, Peter A
Issue Date
2019-04-15
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A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples. 2019, 15(4):629-639 J Clin Sleep MedAbstract
Obstructive sleep apnea (OSA) is a global health issue and is associated with obesity and oropharyngeal crowding. Global data are limited on the effect of ethnicity and sex on these relationships. We compare associations between the apnea-hypopnea index (AHI) and these risk factors across ethnicities and sexes within sleep clinics. This is a cross-sectional, multicenter study of patients with OSA from eight sleep centers representing the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Four distinct ethnic groups were analyzed, using a structured questionnaire: Caucasians (Australia, Iceland, Germany, United States), African Americans (United States), Asians (Taiwan), and South Americans (Brazil). Regression analyses and interaction tests were used to assess ethnic and sex differences in relationships between AHI and anthropometric measures (body mass index [BMI], neck circumference, waist circumference) or Mallampati score. Analyses included 1,585 individuals from four ethnic groups: Caucasian (60.6%), African American (17.5%), Asian (13.1%), and South American (8.9%). BMI was most strongly associated with AHI in South Americans (7.8% increase in AHI per 1 kg/m We demonstrate ethnic and sex variations in associations between obesity and OSA. For similar BMI increases, South American patients show greatest AHI increases compared to African Americans. Findings highlight the importance of considering ethnicity and sex in clinical assessments of OSA risk.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
http://jcsm.aasm.org/ViewAbstract.aspx?pid=31558ae974a485f413a2113503eed53cd6c53
10.5664/jcsm.7730
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