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Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting.

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Authors
Chauhan, Ganesh
Adams, Hieab H H
Satizabal, Claudia L
Bis, Joshua C
Teumer, Alexander
Sargurupremraj, Muralidharan
Hofer, Edith
Trompet, Stella
Hilal, Saima
Smith, Albert Vernon
Jian, Xueqiu
Malik, Rainer
Traylor, Matthew
Pulit, Sara L
Amouyel, Philippe
Mazoyer, Bernard
Zhu, Yi-Cheng
Kaffashian, Sara
Schilling, Sabrina
Beecham, Gary W
Montine, Thomas J
Schellenberg, Gerard D
Kjartansson, Olafur
Guðnason, Vilmundur
Knopman, David S
Griswold, Michael E
Windham, B Gwen
Gottesman, Rebecca F
Mosley, Thomas H
Schmidt, Reinhold
Saba, Yasaman
Schmidt, Helena
Takeuchi, Fumihiko
Yamaguchi, Shuhei
Nabika, Toru
Kato, Norihiro
Rajan, Kumar B
Aggarwal, Neelum T
De Jager, Philip L
Evans, Denis A
Psaty, Bruce M
Rotter, Jerome I
Rice, Kenneth
Lopez, Oscar L
Liao, Jiemin
Chen, Christopher
Cheng, Ching-Yu
Wong, Tien Y
Ikram, Mohammad K
van der Lee, Sven J
Amin, Najaf
Chouraki, Vincent
DeStefano, Anita L
Aparicio, Hugo J
Romero, Jose R
Maillard, Pauline
DeCarli, Charles
Wardlaw, Joanna M
Hernández, Maria Del C Valdés
Luciano, Michelle
Liewald, David
Deary, Ian J
Starr, John M
Bastin, Mark E
Muñoz Maniega, Susana
Slagboom, P Eline
Beekman, Marian
Deelen, Joris
Uh, Hae-Won
Lemmens, Robin
Brodaty, Henry
Wright, Margaret J
Ames, David
Boncoraglio, Giorgio B
Hopewell, Jemma C
Beecham, Ashley H
Blanton, Susan H
Wright, Clinton B
Sacco, Ralph L
Wen, Wei
Thalamuthu, Anbupalam
Armstrong, Nicola J
Chong, Elizabeth
Schofield, Peter R
Kwok, John B
van der Grond, Jeroen
Stott, David J
Ford, Ian
Jukema, J Wouter
Vernooij, Meike W
Hofman, Albert
Uitterlinden, André G
van der Lugt, Aad
Wittfeld, Katharina
Grabe, Hans J
Hosten, Norbert
von Sarnowski, Bettina
Völker, Uwe
Levi, Christopher
Jimenez-Conde, Jordi
Sharma, Pankaj
Sudlow, Cathie L M
Rosand, Jonathan
Woo, Daniel
Cole, John W
Meschia, James F
Slowik, Agnieszka
Thijs, Vincent
Lindgren, Arne
Melander, Olle
Grewal, Raji P
Rundek, Tatjana
Rexrode, Kathy
Rothwell, Peter M
Arnett, Donna K
Jern, Christina
Johnson, Julie A
Benavente, Oscar R
Wasssertheil-Smoller, Sylvia
Lee, Jin-Moo
Wong, Quenna
Mitchell, Braxton D
Rich, Stephen S
McArdle, Patrick F
Geerlings, Mirjam I
van der Graaf, Yolanda
de Bakker, Paul I W
Asselbergs, Folkert W
Srikanth, Velandai
Thomson, Russell
McWhirter, Rebekah
Moran, Chris
Callisaya, Michele
Phan, Thanh
Rutten-Jacobs, Loes C A
Bevan, Steve
Tzourio, Christophe
Mather, Karen A
Sachdev, Perminder S
van Duijn, Cornelia M
Worrall, Bradford B
Dichgans, Martin
Kittner, Steven J
Markus, Hugh S
Ikram, Mohammad A
Fornage, Myriam
Launer, Lenore J
Seshadri, Sudha
Longstreth, W T
Debette, Stéphanie
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Issue Date
2019-01-16

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Citation
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting. 2019, 92(5): E486-E503 Neurology
Abstract
To explore genetic and lifestyle risk factors of MRI-defined brain infarcts (BI) in large population-based cohorts. We performed meta-analyses of genome-wide association studies (GWAS) and examined associations of vascular risk factors and their genetic risk scores (GRS) with MRI-defined BI and a subset of BI, namely, small subcortical BI (SSBI), in 18 population-based cohorts (n = 20,949) from 5 ethnicities (3,726 with BI, 2,021 with SSBI). Top loci were followed up in 7 population-based cohorts (n = 6,862; 1,483 with BI, 630 with SBBI), and we tested associations with related phenotypes including ischemic stroke and pathologically defined BI. The mean prevalence was 17.7% for BI and 10.5% for SSBI, steeply rising after age 65. Two loci showed genome-wide significant association with BI: FBN2, In this multiethnic GWAS meta-analysis, including over 20,000 population-based participants, we identified genetic risk loci for BI requiring validation once additional large datasets become available. High BP, including genetically determined, was the most significant modifiable, causal risk factor for BI.
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To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
Additional Links
https://n.neurology.org/content/92/5/e486
ae974a485f413a2113503eed53cd6c53
10.1212/WNL.0000000000006851
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