Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA.
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Authors
Amele, SPeters, L
Sluzhynska, M
Yakovlev, A
Scherrer, A
Domingo, P
Gerstoft, J
Viard, J P
Gisinger, M
Flisiak, R
Bhaghani, S
Ristola, M
Leen, C
Jablonowska, E
Wandeler, G
Stellbrink, H
Falconer, K
D'Arminio Monforte, A
Horban, A
Rockstroh, J K
Lundgren, J D
Mocroft, A
Issue Date
2019-04
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Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA. 2019, 20(4):264-273 HIV MedAbstract
The aim of the study was to establish a methodology for evaluating the hepatitis C continuum of care in HIV/hepatitis C virus (HCV)-coinfected individuals and to characterize the continuum in Europe on 1 January 2015, prior to widespread access to direct-acting antiviral (DAA) therapy. Stages included in the continuum were as follows: anti-HCV antibody positive, HCV RNA tested, currently HCV RNA positive, ever HCV RNA positive, ever received HCV treatment, completed HCV treatment, follow-up HCV RNA test, and cure. Sustained virological response (SVR) could only be assessed for those with a follow-up HCV RNA test and was defined as a negative HCV RNA result measured > 12 or 24 weeks after stopping treatment. Numbers and percentages for the stages of the HCV continuum of care were as follows: anti-HCV positive (n = 5173), HCV RNA tested (4207 of 5173; 81.3%), currently HCV RNA positive (3179 of 5173; 61.5%), ever HCV RNA positive (n = 3876), initiated HCV treatment (1693 of 3876; 43.7%), completed HCV treatment (1598 of 3876; 41.2%), follow-up HCV RNA test to allow SVR assessment (1195 of 3876; 30.8%), and cure (629 of 3876; 16.2%). The proportion that achieved SVR was 52.6% (629 of 1195). There were significant differences between regions at each stage of the continuum (P < 0.0001). In the proposed HCV continuum of care for HIV/HCV-coinfected individuals, we found major gaps at all stages, with almost 20% of anti-HCV-positive individuals having no documented HCV RNA test and a low proportion achieving SVR, in the pre-DAA era.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.12711ae974a485f413a2113503eed53cd6c53
10.1111/hiv.12711
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