Show simple item record

dc.contributor.authorJonsson, Helgi
dc.contributor.authorFisher, Diana E
dc.contributor.authorEiriksdottir, Gudny
dc.contributor.authorAspelund, Thor
dc.contributor.authorKlein, Ronald
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorCotch, Mary Frances
dc.date.accessioned2019-06-04T11:52:23Z
dc.date.available2019-06-04T11:52:23Z
dc.date.issued2019-04
dc.date.submitted2019-06
dc.identifier.citationHand and knee osteoarthritis are associated with reduced diameters in retinal vessels: the AGES-Reykjavik study. 2019, 39(4):669-677 Rheumatol Inten_US
dc.identifier.issn1437-160X
dc.identifier.pmid30671597
dc.identifier.doi10.1007/s00296-019-04243-6
dc.identifier.urihttp://hdl.handle.net/2336/620925
dc.descriptionNational Institutes of Health (National Institute of Aging) National Institutes of Health (National Eye Institute) National Institutes of Health Icelandic Heart Association Icelandic Parliamenten_US
dc.description.abstractTo investigate the association between osteoarthritis (OA) and microvascular pathology, we examined the relationship between retinal microvascular caliber and osteoarthritis of the hand and knee in an elderly population. The AGES-Reykjavik is a population-based, multidisciplinary longitudinal cohort study of aging. Retinal vessel caliber, hand osteoarthritis and total knee joint replacements due to OA were examined in 4757 individuals (mean age 76 ± 5 years; 57% female). Incident knee joint replacements during 5-year follow-up (n = 2961, mean age 75 ± 5 years; 58% female) were also assessed. Logistic regression analysis, adjusting for age, sex, and body mass index, showed an association between narrow arteriolar caliber and hand OA, as well as knee replacement. After adjustment for other covariates, including statin therapy, this association was significant for both hand OA in men and women [OR 1.10(1.03-1.17), p < 0.01] (per unit standard deviation decrease in CRAE) and TKR prevalence [OR 1.15 (1.01-1.32), p = 0.04], especially for men [OR 1.22 (1.00-1.51) p = 0.04] and also for incident TKRs in men [OR 1.50 (1.07-2.10), p = 0.04]. Narrow venular caliber was associated with hand OA in women [OR 1.10 (1.01-1.21), p = 0.03]. Retinal arterial narrowing in hand and knee OA is present in males as well as females. Venular narrowing in hand OA in women was an unexpected finding and is in contrast with the venular widening usually observed in cardiovascular diseases.en_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.urlhttps://link.springer.com/article/10.1007/s00296-019-04243-6en_US
dc.subjectOsteoarthritisen_US
dc.subjectRetinal vessel diametersen_US
dc.subjectSlitgigten_US
dc.subjectSjónhimnaen_US
dc.subject.meshRetinal Vesselsen_US
dc.subject.meshOsteoarthritisen_US
dc.titleHand and knee osteoarthritis are associated with reduced diameters in retinal vessels: the AGES-Reykjavik study.en_US
dc.typeArticleen_US
dc.contributor.department1 Landspitalinn University Hospital, University of Iceland, Reykjavik, Iceland. helgi@hi.is. 2 University of Iceland, Reykjavik, Iceland. helgi@hi.is. 3 National Eye Institute, National Institutes of Health (NIH), Bethesda, MD, USA. 4 Icelandic Heart Association, Kópavogur, Iceland. 5 University of Iceland, Reykjavik, Iceland. 6 Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.en_US
dc.identifier.journalRheumatology internationalen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeRHE12
dc.source.journaltitleRheumatology international


This item appears in the following Collection(s)

Show simple item record