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dc.contributor.authorBuccheri, Sergio
dc.contributor.authorSarno, Giovanna
dc.contributor.authorFröbert, Ole
dc.contributor.authorGudnason, Thorarinn
dc.contributor.authorLagerqvist, Bo
dc.contributor.authorLindholm, Daniel
dc.contributor.authorMaeng, Michael
dc.contributor.authorOlivecrona, Göran
dc.contributor.authorJames, Stefan
dc.date.accessioned2019-06-14T14:53:41Z
dc.date.available2019-06-14T14:53:41Z
dc.date.issued2019-03
dc.date.submitted2019-06
dc.identifier.citationAssessing the Nationwide Impact of a Registry-Based Randomized Clinical Trial on Cardiovascular Practice. 2019, 12(3):e007381 Circ Cardiovasc Interven_US
dc.identifier.issn1941-7632
dc.identifier.pmid30841711
dc.identifier.doi10.1161/CIRCINTERVENTIONS.118.007381
dc.identifier.urihttp://hdl.handle.net/2336/620939
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractBACKGROUND: Registry-based randomized clinical trials have emerged as useful tools to provide evidence on the comparative efficacy and safety of different therapeutic strategies. However, it remains unknown whether the results of registry-based randomized clinical trials have a sizable impact on daily clinical practice. We sought, therefore, to describe the temporal trends in thrombus aspiration (TA) use in Sweden before, during, and after dissemination of the TASTE trial (Thrombus Aspiration in ST-Elevation Myocardial Infarction in Scandinavia) results. METHODS AND RESULTS: From January 1, 2006, to December 31, 2017, we included all consecutive patients with ST-segment-elevation myocardial infarction undergoing percutaneous revascularization in Sweden. All patients were registered in the Swedish Coronary Angiography and Angioplasty Registry. A total of 55 809 ST-segment-elevation myocardial infarction patients were included. TA use in Sweden substantially decreased after dissemination of TASTE results (from 39.8% to 11.8% during and after TASTE, respectively). Substantial variability in TA use across treating centers was observed before TASTE (TA use ranging from 0% to 70%), but after TASTE both the interhospital variability and the frequency of TA use were markedly reduced. A constant shift in medical practice was seen about 4 months after dissemination of the TASTE trial results. Time trends for all-cause mortality and definite stent thrombosis at 30 days were not associated with variations in TA use ( P values >0.05 using the Granger test). CONCLUSIONS: In Sweden, the results of the TASTE trial were impactful in daily clinical practice and led to a relevant decrease in TA use in ST-segment-elevation myocardial infarction patients undergoing percutaneous revascularization.en_US
dc.description.sponsorshipSwedish government Swedish Association of Local Authorities and Regionsen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.urlhttps://www.ahajournals.org/doi/10.1161/CIRCINTERVENTIONS.118.007381en_US
dc.subjectclinical trialen_US
dc.subjectmortalityen_US
dc.subjectmyocardial infarctionen_US
dc.subjectregistryen_US
dc.subjectthrombosisen_US
dc.subjectHjartadrepen_US
dc.subjectKransæðasjúkdómaren_US
dc.subjectBlóðtappien_US
dc.titleAssessing the Nationwide Impact of a Registry-Based Randomized Clinical Trial on Cardiovascular Practice.en_US
dc.typeArticleen_US
dc.contributor.department1 ] Uppsala Univ, Dept Med Sci, Cardiol, Dag Hammarskjolds Vag 38, S-75185 Uppsala, Sweden Show more [ 2 ] Uppsala Univ, Uppsala Clin Res Ctr, Dag Hammarskjolds Vag 38, S-75185 Uppsala, Sweden Show more [ 3 ] Orebro Univ Hosp, Dept Cardiol, Orebro, Sweden Show more [ 4 ] Landspitali Univ Hosp, Reykjavik, Iceland Show more [ 5 ] Univ Iceland, Dept Cardiol, Reykjavik, Iceland Show more [ 6 ] Univ Iceland, Cardiovasc Res Ctr, Reykjavik, Iceland Show more [ 7 ] Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark Show more [ 8 ] Lund Univ Hosp, Dept Cardiol, Clin Sci, Lund, Swedenen_US
dc.identifier.journalCirculation. Cardiovascular interventionsen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodeCAR12
dc.source.journaltitleCirculation. Cardiovascular interventions


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