GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.
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Stefansson, Olafur A
Lund, Sigrun H
Agustsdottir, Arna B
Halldorsson, Gisli H
Ivarsdottir, Erna V
Boer, Cindy G
Leung, Jason C S
Tang, Nelson L S
Kwok, Timothy C Y
Lee, Jenny S W
Ho, Suzanne C
Center, Jacqueline R
Lee, Seung Hun
Lohmander, L Stefan
Ho-Pham, Lan T
Nguyen, Tuan V
Eisman, John A
van Meurs, Joyce
Uitterlinden, Andre G
Norddahl, Gudmundur L
Gudbjartsson, Daniel F
MetadataShow full item record
CitationGWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures. 2019, 10(1):2054
AbstractBone area is one measure of bone size that is easily derived from dual-energy X-ray absorptiometry (DXA) scans. In a GWA study of DXA bone area of the hip and lumbar spine (N ≥ 28,954), we find thirteen independent association signals at twelve loci that replicate in samples of European and East Asian descent (N = 13,608 - 21,277). Eight DXA area loci associate with osteoarthritis, including rs143384 in GDF5 and a missense variant in COL11A1 (rs3753841). The strongest DXA area association is with rs11614913[T] in the microRNA MIR196A2 gene that associates with lumbar spine area (P = 2.3 × 10-42, β = -0.090) and confers risk of hip fracture (P = 1.0 × 10-8, OR = 1.11). We demonstrate that the risk allele is less efficient in repressing miR-196a-5p target genes. We also show that the DXA area measure contributes to the risk of hip fracture independent of bone density.
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- Genetic variation in the GDF5 region is associated with osteoarthritis, height, hip axis length and fracture risk: the Rotterdam study.
- Authors: Vaes RB, Rivadeneira F, Kerkhof JM, Hofman A, Pols HA, Uitterlinden AG, van Meurs JB
- Issue date: 2009 Nov
- Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.
- Authors: Styrkarsdottir U, Lund SH, Thorleifsson G, Zink F, Stefansson OA, Sigurdsson JK, Juliusson K, Bjarnadottir K, Sigurbjornsdottir S, Jonsson S, Norland K, Stefansdottir L, Sigurdsson A, Sveinbjornsson G, Oddsson A, Bjornsdottir G, Gudmundsson RL, Halldorsson GH, Rafnar T, Jonsdottir I, Steingrimsson E, Norddahl GL, Masson G, Sulem P, Jonsson H, Ingvarsson T, Gudbjartsson DF, Thorsteinsdottir U, Stefansson K
- Issue date: 2018 Dec
- Identification of Novel Loci Associated With Hip Shape: A Meta-Analysis of Genomewide Association Studies.
- Authors: Baird DA, Evans DS, Kamanu FK, Gregory JS, Saunders FR, Giuraniuc CV, Barr RJ, Aspden RM, Jenkins D, Kiel DP, Orwoll ES, Cummings SR, Lane NE, Mullin BH, Williams FM, Richards JB, Wilson SG, Spector TD, Faber BG, Lawlor DA, Grundberg E, Ohlsson C, Pettersson-Kymmer U, Capellini TD, Richard D, Beck TJ, Evans DM, Paternoster L, Karasik D, Tobias JH
- Issue date: 2019 Feb
- Diagnostic agreement at the total hip using different DXA systems and the NHANES III database.
- Authors: Kiebzak GM, Binkley N, Lewiecki EM, Miller PD
- Issue date: 2007 Apr-Jun
- Which is the preferred site for bone mineral density monitoring as an indicator of treatment-related anti-fracture effect in routine clinical practice? A registry-based cohort study.
- Authors: Leslie WD, Martineau P, Bryanton M, Lix LM
- Issue date: 2019 Jul