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dc.contributor.authorBjörnsdóttir, Erla S
dc.contributor.authorMartins, Elisabete R
dc.contributor.authorErlendsdóttir, Helga
dc.contributor.authorHaraldsson, Gunnsteinn
dc.contributor.authorMelo-Cristino, José
dc.contributor.authorRamirez, Mário
dc.contributor.authorKristinsson, Karl G
dc.date.accessioned2019-06-24T15:08:09Z
dc.date.available2019-06-24T15:08:09Z
dc.date.issued2019-06
dc.date.submitted2019
dc.identifier.citationGroup B Streptococcal Neonatal and Early Infancy Infections in Iceland, 1976-2015. 2019, 38(6):620-624 Pediatr Infect Dis Jen_US
dc.identifier.issn1532-0987
dc.identifier.pmid30299423
dc.identifier.doi10.1097/INF.0000000000002214
dc.identifier.urihttp://hdl.handle.net/2336/620957
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractBACKGROUND: Despite a risk-based peripartum chemoprophylaxis approach in Iceland since 1996, Streptococcus agalactiae [group B streptococci (GBS)] remains an important cause of early-onset [<7 days, early-onset disease (EOD)] and late-onset disease (LOD; 7 days to 3 months). METHODS: We studied GBS invasive disease in children <1 year in Iceland in 1976-2015. Bacteria (n = 98) were characterized by susceptibility to a panel of antimicrobials, capsular serotyping, resistance genes, surface protein and pilus-locus profiling and multilocus sequence typing. RESULTS: Both EOD and LOD increased during the early years, but while EOD subsequently decreased from 0.7/1000 live births in 1991-1995 to 0.2/1000 in 2011-2015, LOD showed a nonsignificant decrease from its peak value of 0.6/1000 in 2001-2005 to 0.4/1000 in 2006-2015. Serotype III was the most frequently found (n = 48), represented mostly by the hypervirulent lineage CC17/III/rib/PI-1+PI-2b (62%), but also by CC19/III/rib/PI-1+PI-2a (35%) frequently associated with colonization. Serotype Ia (n = 22) was represented by CC23/Ia/eps/PI-2a (68%) and CC7/Ia/bca/PI-1+PI-2b (23%) of possible zoonotic origin. Resistance to erythromycin and clindamycin was increasingly detected in the last years of the study (5 of the 9 cases were isolated after 2013), including representatives of a multiresistant CC17/III/rib/PI-2b sublineage described recently in other countries and expressing resistance to erythromycin, clindamycin and streptomycin. CONCLUSIONS: The risk-based chemoprophylaxis adopted in Iceland possibly contributed to the decline of EOD but has had limited effect on LOD. GBS causing neonatal and early infancy invasive infections in Iceland are genetically diverse, and the recent emergence of antimicrobial resistant lineages may reduce the choices for prophylaxis and therapy of these infections.en_US
dc.description.sponsorshipGovernment of Iceland Government of Lichtenstein Landspitali University Hospital Research Fund Fundacao para a Ciencia e a Tecnologia Government of Norwayen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.urlhttps://journals.lww.com/pidj/fulltext/2019/06000/Group_B_Streptococcal_Neonatal_and_Early_Infancy.16.aspxen_US
dc.subjectStreptococcus Group Ben_US
dc.subjectBakteríusjúkdómaren_US
dc.subjectGerlaren_US
dc.subjectUngbörnen_US
dc.subjectSýklalyfen_US
dc.subjectSýklalyfjaónæmien_US
dc.subject.meshStreptococcus agalactiaeen_US
dc.subject.meshInfant, Newborn, Diseasesen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.titleGroup B Streptococcal Neonatal and Early Infancy Infections in Iceland, 1976-2015.en_US
dc.typeArticleen_US
dc.contributor.department1 From the Department of Clinical Microbiology, Landspitali University Hospital, Reykjavik, Iceland. 2 BioMedical Centre of the University of Iceland, Reykjavik, Iceland. 3 Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.en_US
dc.identifier.journalPediatric infectious disease journalen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodeNAF12
dc.departmentcodeBAC12
dc.source.journaltitleThe Pediatric infectious disease journal


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