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dc.contributor.authorIngadottir, Arora Ros
dc.contributor.authorBeck, Anne Marie
dc.contributor.authorBaldwin, Christine
dc.contributor.authorWeekes, Christine Elizabeth
dc.contributor.authorGeirsdottir, Olof Gudny
dc.contributor.authorRamel, Alfons
dc.contributor.authorGislason, Thorarinn
dc.contributor.authorGunnarsdottir, Ingibjorg
dc.date.accessioned2019-06-25T13:43:54Z
dc.date.available2019-06-25T13:43:54Z
dc.date.issued2019-01-03
dc.date.submitted2019-06
dc.identifier.citationOral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial. 2019, 6(1):e000349 BMJ Open Respir Resen_US
dc.identifier.issn2052-4439
dc.identifier.pmid30687503
dc.identifier.doi10.1136/bmjresp-2018-000349
dc.identifier.urihttp://hdl.handle.net/2336/620959
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractINTRODUCTION: Intervention studies have mainly used oral nutritional supplements (ONS) for the management of patients with chronic obstructive pulmonary disease (COPD) identified as at nutritional risk. In this 12-month randomised feasibility trial, we assessed the (1) feasibility of the recruitment, retention and provision of two interventions: ONS and between-meal snacks (snacks) and (2) the potential impact of the provision of snacks and ONS on body weight and quality of life in patients with COPD. METHODS : Hospitalised patients with COPD, at nutritional risk, were randomised to ONS (n=19) or snacks (n=15) providing 600 kcal and 22 g protein a day in addition to regular daily diet. The intervention started in hospital and was continued for 12 months after discharge from the hospital. RESULTS : Study recruitment rate was n=34 (45%) and retention rate at 12 months was similar for both groups: n=13 (68%) in the ONS group and n=10 (67%) in the Snacks group. Both groups gained weight from baseline to 12 months (2.3±4.6 kg (p=0.060) in the ONS group and 4.4±6.4 kg (p=0.030) in the Snacks group). The St George's Respiratory Questionnaire total score improved from baseline to 12 months in both groups (score 3.9±11.0 (p=0.176) in the ONS group and score 8.9±14.1 (p=0.041) in the Snacks group). DISCUSSION : In patients with COPD who are at nutritional risk snacks are at least as feasible and effective as ONS, however, adequately powered trials that take account of the difficulties in recruiting this patient group are required to confirm this effect.en_US
dc.description.sponsorshipIcelandic Research Fund of the Icelandic Centre for Research Eimskip University Fund Landspitali University Hospital Research Fund Nutricia (Icepharma)en_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.urlhttps://bmjopenrespres.bmj.com/content/6/1/e000349en_US
dc.subjectLangvinn lungnateppaen_US
dc.subjectFæðubótarefnien_US
dc.subjectNæringarefnien_US
dc.subjectMillimál
dc.subject.meshDietary Supplementsen_US
dc.subject.meshSnacksen_US
dc.subject.meshNutrition Therapyen_US
dc.subject.meshPulmonary Disease, Chronic Obstructiveen_US
dc.titleOral nutrition supplements and between-meal snacks for nutrition therapy in patients with COPD identified as at nutritional risk: a randomised feasibility trial.en_US
dc.typeArticleen_US
dc.contributor.department1 Unit for Nutrition Research, Landspitali University Hospital and Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. 2 Department of Clinical Nutrition, Landspitali University Hospital, Reykjavik, Iceland. 3 Faculty of Health, Copenhagen University College, Copenhagen, Denmark. 4 Research Unit for Nutrition, Herlev and Gentofte Hospital, Copenhagen, Denmark. 5 Department of Nutritional Sciences, King's College London, London, UK. 6 The Icelandic Gerontological Research Institute, Landspitali University Hospital and University of Iceland, Reykjavik, Iceland. 7 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 8 Department of Sleep, Landspitali University Hospital, Reykjavik, Iceland.en_US
dc.identifier.journalBMJ open respiratory researchen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeNUR12
dc.departmentcodePAD12
dc.source.journaltitleBMJ open respiratory research
refterms.dateFOA2019-06-25T13:43:54Z


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