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dc.contributor.authorLytras, Theodore
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorKromhout, Hans
dc.contributor.authorCarsin, Anne-Elie
dc.contributor.authorAntó, Josep Maria
dc.contributor.authorBentouhami, Hayat
dc.contributor.authorWeyler, Joost
dc.contributor.authorHeinrich, Joachim
dc.contributor.authorNowak, Dennis
dc.contributor.authorUrrutia, Isabel
dc.contributor.authorMartínez-Moratalla, Jesús
dc.contributor.authorGullón, José Antonio
dc.contributor.authorVega, Antonio Pereira
dc.contributor.authorRaherison Semjen, Chantal
dc.contributor.authorPin, Isabelle
dc.contributor.authorDemoly, Pascal
dc.contributor.authorLeynaert, Bénédicte
dc.contributor.authorVillani, Simona
dc.contributor.authorGíslason, Thorarinn
dc.contributor.authorSvanes, Øistein
dc.contributor.authorHolm, Mathias
dc.contributor.authorForsberg, Bertil
dc.contributor.authorNorbäck, Dan
dc.contributor.authorMehta, Amar J
dc.contributor.authorProbst-Hensch, Nicole
dc.contributor.authorBenke, Geza
dc.contributor.authorJogi, Rain
dc.contributor.authorTorén, Kjell
dc.contributor.authorSigsgaard, Torben
dc.contributor.authorSchlünssen, Vivi
dc.contributor.authorOlivieri, Mario
dc.contributor.authorBlanc, Paul D
dc.contributor.authorWatkins, John
dc.contributor.authorBono, Roberto
dc.contributor.authorBuist, A Sonia
dc.contributor.authorVermeulen, Roel
dc.contributor.authorJarvis, Deborah
dc.contributor.authorZock, Jan-Paul
dc.date.accessioned2019-08-27T13:47:06Z
dc.date.available2019-08-27T13:47:06Z
dc.date.issued2019-04
dc.date.submitted2019-08
dc.identifier.citationOccupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey. 2019,76(4): 222-229 Occup Environ Med.en_US
dc.identifier.issn1470-7926
dc.identifier.pmid30700596
dc.identifier.doi10.1136/oemed-2018-105274
dc.identifier.urihttp://hdl.handle.net/2336/621015
dc.description.abstractOBJECTIVES: Chronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey. METHODS: Population samples aged 20-44 were randomly selected in 1991-1993, and followed up twice over 20 years. Participants without chronic cough or phlegm at baseline were analysed. Coded job histories during follow-up were linked to the ALOHA Job Exposure Matrix, generating occupational exposure estimates to 12 categories of chemical agents. Their association with CB incidence over both follow-ups was examined with Poisson models using generalised estimating equations. RESULTS: 8794 participants fulfilled the inclusion criteria, contributing 13 185 observations. Only participants exposed to metals had a higher incidence of CB (relative risk (RR) 1.70, 95% CI 1.16 to 2.50) compared with non-exposed to metals. Mineral dust exposure increased the incidence of chronic phlegm (RR 1.72, 95% CI 1.43 to 2.06). Incidence of chronic phlegm was increased in men exposed to gases/fumes and to solvents and in women exposed to pesticides. CONCLUSIONS: Occupational exposures are associated with chronic phlegm and CB, and the evidence is strongest for metals and mineral dust exposure. The observed differences between men and women warrant further investigation.en_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.urlhttps://oem.bmj.com/content/76/4/222en_US
dc.subjectepidemiologyen_US
dc.subjectlongitudinal studiesen_US
dc.subjectrespiratoryen_US
dc.subjectretrospective exposure assessmenten_US
dc.subjectBerkjubólgaen_US
dc.subjectAtvinnusjúkdómaren_US
dc.subjectUmhverfisáhrifen_US
dc.subject.meshBronchitis, Chronicen_US
dc.subject.meshOccupational Exposureen_US
dc.titleOccupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey.en_US
dc.typeArticleen_US
dc.contributor.department1 Barcelona Institute of Global Health (ISGlobal), Barcelona, Spain. 2 Universitat Pompeu Fabra (UPF), Barcelona, Spain. 3 CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 4 Hospital del Mar Medical Research Institute, Barcelona, Spain. 5 IRAS, University of Utrecht, Utrecht, The Netherlands. 6 Department of Epidemiology and Social Medicine (ESOC), Faculty of Medicine and Health Sciences, StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium. 7 Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Comprehensive Pneumology Centre, German Centre for Lung Research, University Hospital of Ludwig-Maximilians-University, Munich, Germany. 8 Pulmonology Department, Galdakao Hospital, Galdakao, Spain. 9 Servicio de Neumología, Complejo Hospitalario Universitario, Albacete, Spain. 10 Facultad de Medicina Albacete, University of Castilla-La Mancha, Ciudad Real, Spain. 11 Respiratory Department, Hospital Universitario San Agustín, Avilés, Spain. 12 Pulmonology and Allergy Clinical Unit, University Hospital Juan Ramón Jiménez, Huelva, Spain. 13 Inserm, Bordeaux Population Health Research Center, Team EPICENE, UMR 1219, Université de Bordeaux, Bordeaux, France. 14 Department of Pédiatrie, CHU de Grenoble Alpes, Grenoble, France. 15 U1209, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, INSERM, Grenoble, France. 16 Université Grenoble Alpes, Grenoble, France. 17 University Hospital of Montpellier, Montpellier, France. 18 Sorbonne Universités, Paris, France. 19 Inserm UMR 1152-Equipe Epidémiologie, Université Paris Diderot, Paris, France. 20 Section of Epidemiology and Medical Statistics, Department of Health Sciences, University of Pavia, Pavia, Italy. 21 Department of Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland. 22 Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 23 Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway. 24 Department of Clinical Science, University of Bergen, Bergen, Norway. 25 Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. 26 Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden. 27 Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 28 Office of Research and Evaluation, Boston Public Health Commission, Boston, Massachusetts, USA. 29 Department Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland. 30 Monash Centre for Occupation and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. 31 Lung Clinic, Tartu University Hospital, Tartu, Europe. 32 Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 33 Section for Environment, Occupation and Health, Department of Public Health, Danish Ramazzini Center, Aarhus University, Aarhus, Denmark. 34 National Research Center for the Working Environment, Copenhagen, Denmark. 35 Unit of Occupational Medicine, University Hospital of Verona, Verona, Italy. 36 San Francisco Veterans Affairs Medical Center, University of California San Francisco, San Francisco, California, USA. 37 School of Medicine, Cardiff University, Cardiff, Wales, UK. 38 Public Health Wales, Cardiff, Wales, UK. 39 Department of Public Health and Pediatrics, University of Turin, Turin, Italy. 40 Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA. 41 Population Health and Occupational Disease, National Heart and Lung Institute, MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. 42 MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.en_US
dc.identifier.journalOccupational and Environmental Medicineen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodePAD12
dc.source.journaltitleOccupational and environmental medicine


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