• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Stefánsson, Einar
Olafsdottir, Olof Birna
Eliasdottir, Thorunn S
Vehmeijer, Wouter
Einarsdottir, Anna Bryndis
Bek, Toke
Torp, Thomas Lee
Grauslund, Jakob
Eysteinsson, Thor
Karlsson, Robert Arnar
Van Keer, Karel
Stalmans, Ingeborg
Vandewalle, Evelien
Todorova, Margarita G
Hammer, Martin
Garhöfer, Gerhard
Schmetterer, Leopold
Šín, Martin
Hardarson, Sveinn Hakon
Show allShow less
Issue Date
2019-05

Metadata
Show full item record
Citation
Retinal oximetry: Metabolic imaging for diseases of the retina and brain. 2019, 70:1-22. doi: 10.1016/j.preteyeres.2019.04.001 Prog Retin Eye Res
Abstract
Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. In diabetic retinopathy, retinal venous oxygen saturation is elevated and arteriovenous difference progressively reduced in advanced stages of retinopathy compared with healthy persons. This correlates with pathophysiology of diabetic retinopathy where hypoxia stimulates VEGF production. Laser treatment and vitrectomy both improve retinal oximetry values, which correlate with clinical outcome. The oximetry biomarker may allow automatic measurement of severity of diabetic retinopathy and predict its response to treatment. Central retinal vein occlusion is characterized by retinal hypoxia, which is evident in retinal oximetry. The retinal hypoxia seen on oximetry correlates with the extent of peripheral ischemia, visual acuity and thickness of macular edema. This biomarker may help diagnose and measure severity of vein occlusion and degree of retinal ischemia. Glaucomatous retinal atrophy is associated with reduced oxygen consumption resulting in reduced arteriovenous difference and higher retinal venous saturation. The oximetry findings correlate with worse visual field, thinner nerve fiber layer and smaller optic disc rim. This provides an objective biomarker for glaucomatous damage. In retinitis pigmentosa, an association exists between advanced atrophy, worse visual field and higher retinal venous oxygen saturation, lower arteriovenous difference. This biomarker may allow measurement of severity and progression of retinitis pigmentosa and other atrophic retinal diseases. Retinal oximetry offers visible light imaging of systemic and central nervous system vessels. It senses hypoxia in cardiac and pulmonary diseases. Oximetry biomarkers have been discovered in Alzheimer's disease and multiple sclerosis and oxygen levels in the retina correspond well with brain
Description
To access publisher's full text version of this article click on the hyperlink below
Additional Links
https://www.sciencedirect.com/science/article/pii/S1350946218300806
ae974a485f413a2113503eed53cd6c53
10.1016/j.preteyeres.2019.04.001
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases.
  • Authors: Stefánsson E, Olafsdottir OB, Einarsdottir AB, Eliasdottir TS, Eysteinsson T, Vehmeijer W, Vandewalle E, Bek T, Hardarson SH
  • Issue date: 2017 May 1
  • Retinal oximetry and systemic arterial oxygen levels.
  • Authors: Eliasdottir TS
  • Issue date: 2018 Nov
  • Retinal oximetry.
  • Authors: Hardarson SH
  • Issue date: 2013 Mar
  • Oximetry in glaucoma: correlation of metabolic change with structural and functional damage.
  • Authors: Vandewalle E, Abegão Pinto L, Olafsdottir OB, De Clerck E, Stalmans P, Van Calster J, Zeyen T, Stefánsson E, Stalmans I
  • Issue date: 2014 Mar
  • Current use of the automatic retinal oximetry. Review.
  • Authors: Hübnerová P, Mlčák P, Šínová I, Karhanová M, Šín M
  • Issue date: 2020 Winter

Related items

Showing items related by title, author, creator and subject.

  • Thumbnail

    Dorzolamide increases retinal oxygen tension after branch retinal vein occlusion

    Noergaard, Michael Hove; Bach-Holm, Daniella; Scherfig, Erik; Bang, Kurt; Jensen, Peter Koch; Kiilgaard, Jens Folke; Stefansson, Einar; la Cour, Morten; Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark. hovemichael@yahoo.com (Association For Research In Vision And Ophthalmology (Arvo), 2008-03-01)
    PURPOSE: To study the effect of dorzolamide on the preretinal oxygen tension (RPO(2)) in retinal areas affected by experimental branch retinal vein occlusion (BRVO) in pigs. METHODS: Experimental BRVO was induced by diathermy close to the optic disc. RPO(2) was measured with an oxygen-sensitive electrode 0.5 mm above the BRVO-affected area, which was compared to the retinal areas not affected by BRVO. In one group of five pigs, RPO(2) was measured at baseline, 1 and 3 hours after BRVO, and after intravenous injection of 500 mg dorzolamide. In a second group of five pigs, RPO(2) was measured 1 week after the BRVO, both before and after intravenous injection of 500 mg dorzolamide. RESULTS: The average baseline RPO(2) was 2.64 +/- 0.09 kPa (mean +/- SD). In the BRVO-affected areas, RPO(2) decreased significantly (by 0.67 +/- 0.29 and 0.94 +/- 0.13 kPa) at 1 hour and 3 hours after BRVO induction. In the non-BRVO areas RPO(2) increased significantly (by 0.51 +/- 0.14 kPa) 1 hour after BRVO induction, but subsequently decreased and reached baseline 3 hours after BRVO induction. One week after BRVO induction, RPO(2) was 0.67 +/- 0.29 kPa lower in affected areas when compared with the non-BRVO areas. In the BRVO-affected areas, dorzolamide increased RPO(2) significantly (by 0.36 +/- 0.21 kPa at 3 to 4 hours and by 0.67 +/- 0.40 kPa) 1 week after BRVO induction. CONCLUSIONS: Retinal hypoxia induced by experimental BRVO remained significant 1 week after BRVO. Dorzolamide increased retinal oxygen tension in the BRVO-affected areas both at 4 hours and 1 week after experimental BRVO in pigs.
  • Thumbnail

    Retinal oximetry in central retinal artery occlusion.

    Hardarson, Sveinn H; Elfarsson, Andri; Agnarsson, Bjarni A; Stefánsson, Einar; Univ Iceland, Landspitali Univ Hosp, Dept Ophthalmol, IS-101 Reykjavik, Iceland, Oxymap Ehf, Reykjavik, Iceland, Univ Iceland, Landspitali Univ Hosp, Dept Pathol, IS-101 Reykjavik, Iceland (Wiley-Blackwell, 2013-03)
  • Thumbnail

    Retinal vessel oxygen saturation and vessel diameter in retinitis pigmentosa.

    Eysteinsson, Thor; Hardarson, Sveinn H; Bragason, David; Stefánsson, Einar; Univ Iceland, Reykjavik, Iceland, Univ Iceland, Landspitali Univ Hosp, Reykjavik, Iceland (Wiley-Blackwell, 2014-08)
    To assess retinal vessel oxygen saturation and retinal vessel diameter in retinitis pigmentosa.

DSpace software (copyright © 2002 - 2021)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.