A catalog of genetic loci associated with kidney function from analyses of a million individuals.
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Authors
Wuttke, MatthiasLi, Yong
Li, Man
Sieber, Karsten B
Feitosa, Mary F
Gorski, Mathias
Tin, Adrienne
Wang, Lihua
Chu, Audrey Y
Hoppmann, Anselm
Kirsten, Holger
Giri, Ayush
Chai, Jin-Fang
Sveinbjornsson, Gardar
Tayo, Bamidele O
Nutile, Teresa
Fuchsberger, Christian
Marten, Jonathan
Cocca, Massimiliano
Ghasemi, Sahar
Xu, Yizhe
Horn, Katrin
Noce, Damia
van der Most, Peter J
Sedaghat, Sanaz
Yu, Zhi
Akiyama, Masato
Afaq, Saima
Ahluwalia, Tarunveer S
Almgren, Peter
Amin, Najaf
Ärnlöv, Johan
Bakker, Stephan J L
Bansal, Nisha
Baptista, Daniela
Bergmann, Sven
Biggs, Mary L
Biino, Ginevra
Boehnke, Michael
Boerwinkle, Eric
Boissel, Mathilde
Bottinger, Erwin P
Boutin, Thibaud S
Brenner, Hermann
Brumat, Marco
Burkhardt, Ralph
Butterworth, Adam S
Campana, Eric
Campbell, Archie
Campbell, Harry
Canouil, Mickaël
Carroll, Robert J
Catamo, Eulalia
Chambers, John C
Chee, Miao-Ling
Chee, Miao-Li
Chen, Xu
Cheng, Ching-Yu
Cheng, Yurong
Christensen, Kaare
Cifkova, Renata
Ciullo, Marina
Concas, Maria Pina
Cook, James P
Coresh, Josef
Corre, Tanguy
Sala, Cinzia Felicita
Cusi, Daniele
Danesh, John
Daw, E Warwick
de Borst, Martin H
De Grandi, Alessandro
de Mutsert, Renée
de Vries, Aiko P J
Degenhardt, Frauke
Delgado, Graciela
Demirkan, Ayse
Di Angelantonio, Emanuele
Dittrich, Katalin
Divers, Jasmin
Dorajoo, Rajkumar
Eckardt, Kai-Uwe
Ehret, Georg
Elliott, Paul
Endlich, Karlhans
Evans, Michele K
Felix, Janine F
Foo, Valencia Hui Xian
Franco, Oscar H
Franke, Andre
Freedman, Barry I
Freitag-Wolf, Sandra
Friedlander, Yechiel
Froguel, Philippe
Gansevoort, Ron T
Gao, He
Gasparini, Paolo
Gaziano, J Michael
Giedraitis, Vilmantas
Gieger, Christian
Girotto, Giorgia
Giulianini, Franco
Gögele, Martin
Gordon, Scott D
Gudbjartsson, Daniel F
Gudnason, Vilmundur
Haller, Toomas
Hamet, Pavel
Harris, Tamara B
Hartman, Catharina A
Hayward, Caroline
Hellwege, Jacklyn N
Heng, Chew-Kiat
Hicks, Andrew A
Hofer, Edith
Huang, Wei
Hutri-Kähönen, Nina
Hwang, Shih-Jen
Ikram, M Arfan
Indridason, Olafur S
Ingelsson, Erik
Ising, Marcus
Jaddoe, Vincent W V
Jakobsdottir, Johanna
Jonas, Jost B
Joshi, Peter K
Josyula, Navya Shilpa
Jung, Bettina
Kähönen, Mika
Kamatani, Yoichiro
Kammerer, Candace M
Kanai, Masahiro
Kastarinen, Mika
Kerr, Shona M
Khor, Chiea-Chuen
Kiess, Wieland
Kleber, Marcus E
Koenig, Wolfgang
Kooner, Jaspal S
Körner, Antje
Kovacs, Peter
Kraja, Aldi T
Krajcoviechova, Alena
Kramer, Holly
Krämer, Bernhard K
Kronenberg, Florian
Kubo, Michiaki
Kühnel, Brigitte
Kuokkanen, Mikko
Kuusisto, Johanna
La Bianca, Martina
Laakso, Markku
Lange, Leslie A
Langefeld, Carl D
Lee, Jeannette Jen-Mai
Lehne, Benjamin
Lehtimäki, Terho
Lieb, Wolfgang
Lim, Su-Chi
Lind, Lars
Lindgren, Cecilia M
Liu, Jun
Liu, Jianjun
Loeffler, Markus
Loos, Ruth J F
Lucae, Susanne
Lukas, Mary Ann
Lyytikäinen, Leo-Pekka
Mägi, Reedik
Magnusson, Patrik K E
Mahajan, Anubha
Martin, Nicholas G
Martins, Jade
März, Winfried
Mascalzoni, Deborah
Matsuda, Koichi
Meisinger, Christa
Meitinger, Thomas
Melander, Olle
Metspalu, Andres
Mikaelsdottir, Evgenia K
Milaneschi, Yuri
Miliku, Kozeta
Mishra, Pashupati P
Mohlke, Karen L
Mononen, Nina
Montgomery, Grant W
Mook-Kanamori, Dennis O
Mychaleckyj, Josyf C
Nadkarni, Girish N
Nalls, Mike A
Nauck, Matthias
Nikus, Kjell
Ning, Boting
Nolte, Ilja M
Noordam, Raymond
O'Connell, Jeffrey
O'Donoghue, Michelle L
Olafsson, Isleifur
Oldehinkel, Albertine J
Orho-Melander, Marju
Ouwehand, Willem H
Padmanabhan, Sandosh
Palmer, Nicholette D
Palsson, Runolfur
Penninx, Brenda W J H
Perls, Thomas
Perola, Markus
Pirastu, Mario
Pirastu, Nicola
Pistis, Giorgio
Podgornaia, Anna I
Polasek, Ozren
Ponte, Belen
Porteous, David J
Poulain, Tanja
Pramstaller, Peter P
Preuss, Michael H
Prins, Bram P
Province, Michael A
Rabelink, Ton J
Raffield, Laura M
Raitakari, Olli T
Reilly, Dermot F
Rettig, Rainer
Rheinberger, Myriam
Rice, Kenneth M
Ridker, Paul M
Rivadeneira, Fernando
Rizzi, Federica
Roberts, David J
Robino, Antonietta
Rossing, Peter
Rudan, Igor
Rueedi, Rico
Ruggiero, Daniela
Ryan, Kathleen A
Saba, Yasaman
Sabanayagam, Charumathi
Salomaa, Veikko
Salvi, Erika
Saum, Kai-Uwe
Schmidt, Helena
Schmidt, Reinhold
Schöttker, Ben
Schulz, Christina-Alexandra
Schupf, Nicole
Shaffer, Christian M
Shi, Yuan
Smith, Albert V
Smith, Blair H
Soranzo, Nicole
Spracklen, Cassandra N
Strauch, Konstantin
Stringham, Heather M
Stumvoll, Michael
Svensson, Per O
Szymczak, Silke
Tai, E-Shyong
Tajuddin, Salman M
Tan, Nicholas Y Q
Taylor, Kent D
Teren, Andrej
Tham, Yih-Chung
Thiery, Joachim
Thio, Chris H L
Thomsen, Hauke
Thorleifsson, Gudmar
Toniolo, Daniela
Tönjes, Anke
Tremblay, Johanne
Tzoulaki, Ioanna
Uitterlinden, André G
Vaccargiu, Simona
van Dam, Rob M
van der Harst, Pim
van Duijn, Cornelia M
Velez Edward, Digna R
Verweij, Niek
Vogelezang, Suzanne
Völker, Uwe
Vollenweider, Peter
Waeber, Gerard
Waldenberger, Melanie
Wallentin, Lars
Wang, Ya Xing
Wang, Chaolong
Waterworth, Dawn M
Bin Wei, Wen
White, Harvey
Whitfield, John B
Wild, Sarah H
Wilson, James F
Wojczynski, Mary K
Wong, Charlene
Wong, Tien-Yin
Xu, Liang
Yang, Qiong
Yasuda, Masayuki
Yerges-Armstrong, Laura M
Zhang, Weihua
Zonderman, Alan B
Rotter, Jerome I
Bochud, Murielle
Psaty, Bruce M
Vitart, Veronique
Wilson, James G
Dehghan, Abbas
Parsa, Afshin
Chasman, Daniel I
Ho, Kevin
Morris, Andrew P
Devuyst, Olivier
Akilesh, Shreeram
Pendergrass, Sarah A
Sim, Xueling
Böger, Carsten A
Okada, Yukinori
Edwards, Todd L
Snieder, Harold
Stefansson, Kari
Hung, Adriana M
Heid, Iris M
Scholz, Markus
Teumer, Alexander
Köttgen, Anna
Pattaro, Cristian
Issue Date
2019-06-01
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A catalog of genetic loci associated with kidney function from analyses of a million individuals. 2019, 51(6): 957-972 Nat GenetAbstract
Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://www.nature.com/articles/s41588-019-0407-xhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698888/
ae974a485f413a2113503eed53cd6c53
10.1038/s41588-019-0407-x
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