• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles (Tímaritsgreinar)
  • English Journal Articles
  • View Item
  •   Home
  • Journal Articles (Tímaritsgreinar)
  • English Journal Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Chapuis, Aude G
Egan, Daniel N
Bar, Merav
Schmitt, Thomas M
McAfee, Megan S
Paulson, Kelly G
Voillet, Valentin
Gottardo, Raphael
Ragnarsson, Gunnar B
Bleakley, Marie
Yeung, Cecilia C
Muhlhauser, Petri
Nguyen, Hieu N
Kropp, Lara A
Castelli, Luca
Wagener, Felecia
Hunter, Daniel
Lindberg, Marcus
Cohen, Kristen
Seese, Aaron
McElrath, M Juliana
Duerkopp, Natalie
Gooley, Ted A
Greenberg, Philip D
Show allShow less
Issue Date
2019-07

Metadata
Show full item record
Citation
T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant. 2019, 25(7):1064-1072 Nat Med
Abstract
Relapse after allogeneic hematopoietic cell transplantation (HCT) is the leading cause of death in patients with acute myeloid leukemia (AML) entering HCT with poor-risk features1-3. When HCT does produce prolonged relapse-free survival, it commonly reflects graft-versus-leukemia effects mediated by donor T cells reactive with antigens on leukemic cells4. As graft T cells have not been selected for leukemia specificity and frequently recognize proteins expressed by many normal host tissues, graft-versus-leukemia effects are often accompanied by morbidity and mortality from graft-versus-host disease5. Thus, AML relapse risk might be more effectively reduced with T cells expressing receptors (TCRs) that target selected AML antigens6. We therefore isolated a high-affinity Wilms' Tumor Antigen 1-specific TCR (TCRC4) from HLA-A2+ normal donor repertoires, inserted TCRC4 into Epstein-Bar virus-specific donor CD8+ T cells (TTCR-C4) to minimize graft-versus-host disease risk and enhance transferred T cell survival7,8, and infused these cells prophylactically post-HCT into 12 patients ( NCT01640301 ). Relapse-free survival was 100% at a median of 44 months following infusion, while a concurrent comparative group of 88 patients with similar risk AML had 54% relapse-free survival (P = 0.002). TTCR-C4 maintained TCRC4 expression, persisted long-term and were polyfunctional. This strategy appears promising for preventing AML recurrence in individuals at increased risk of post-HCT relapse.
Description
To access publisher's full text version of this article click on the hyperlink below
Additional Links
https://www.nature.com/articles/s41591-019-0472-9
ae974a485f413a2113503eed53cd6c53
10.1038/s41591-019-0472-9
Scopus Count
Collections
English Journal Articles

entitlement

 

DSpace software (copyright © 2002 - 2022)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.