Red blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003-2016.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsThorvaldsson, Hrafn Hliddal
Sveinsdottir, Signy Vala
Olafsson, Gunnar Bjorn
Halldorsdottir, Anna Margret
MetadataShow full item record
CitationRed blood cell utilization and transfusion triggers in patients diagnosed with chronic lymphocytic leukaemia in Iceland 2003-2016. 2019, 114(5):495-504 Vox Sang
AbstractBACKGROUND AND OBJECTIVES: Revised Icelandic guidelines proposed a restrictive haemoglobin (Hb) threshold of 70 g/l for red blood cell (RBC) transfusions in general, but 100 g/l for malignancies/bone marrow suppression. Chronic lymphocytic leukaemia (CLL) is frequently complicated by anaemia. The objective was to investigate RBC transfusion practices in CLL. MATERIALS AND METHODS: This retrospective nation-wide study utilized an Icelandic registry of CLL patients diagnosed between 2003 and 2016. Medical records were reviewed and haemoglobin transfusion triggers compared for two periods: Earlier (2003-2012) and latter (2013-2017). RESULTS: Two hundred and thirteen patients were diagnosed with CLL over the period whereof 77 (36·2%) received RBC transfusion(s). Median time from diagnosis to first transfusion was 2·2 years. Higher age, Rai stage 3/4 at diagnosis (P < 0·05) and chemotherapy (P < 0·001) were associated with increased odds of transfusions. Shorter time to first transfusion correlated with higher age (P < 0·001) and Rai stage (P = 0·02) at diagnosis. The mean Hb trigger was 90·4 and 81·2 in the earlier and latter period respectively (P = 0·01). This difference in Hb triggers was most pronounced in patients without documented bone marrow involvement, or 80·5 g/l compared to 93·5 g/l (P = 0·004). The median time from diagnosis to transfusion was longer in the latter period (2·9 years vs. 1·6 years, P = 0·01). After RBC transfusions the survival decreased significantly (P < 0·001). CONCLUSION: One-third of CLL patients received RBC transfusions but few were heavily transfused. Older age, Rai stage, and chemotherapy predicted RBC use. The Hb transfusion trigger decreased over time while time to first RBC transfusion increased. RBC transfusions predict poor survival.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
- Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study.
- Authors: English SW, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Garland A, Fergusson D, Zarychanski R, van Walraven C, Montroy K, Ziegler J, Dupont-Chouinard R, Carignan R, Dhaliwal A, Mallick R, Sinclair J, Boutin A, Pagliarello G, Tinmouth A, McIntyre L, Canadian Critical Care Trials Group.
- Issue date: 2018 Jul 4
- Patient blood transfusion management: discharge hemoglobin level as a surrogate marker for red blood cell utilization appropriateness.
- Authors: Edwards J, Morrison C, Mohiuddin M, Tchatalbachev V, Patel C, Schwickerath VL, Menitove JE, Singh G
- Issue date: 2012 Nov
- Triggers and appropriateness of red blood cell transfusions in the postpartum patient--a retrospective audit.
- Authors: So-Osman C, Cicilia J, Brand A, Schipperus M, Berning B, Scherjon S
- Issue date: 2010 Jan
- [Chronic lymphocytic leukemia in Iceland from 2003 to 2013: Incidence, presentation and diagnosis].
- Authors: Olafsson GB, Steingrimsdottir H, Vidarsson B, Halldorsdottir AM
- Issue date: 2016 Apr
- Hemoglobin transfusion trigger in an internal medicine department - A "real world" six year experience.
- Authors: Rahimi-Levene N, Ziv-Baran T, Peer V, Golik A, Kornberg A, Zeidenstein R, Koren-Michowitz M
- Issue date: 2018