Improving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Ciccaglione, Anna Rita
Ngui, Siew Lin
de Sousa, Rita
Aberle, Stephan W
Ederth, Josefine Lundberg
Filipović, Sanja Kurečić
Fischer, Thea Kølsen
Wenzel, Jürgen J
MetadataShow full item record
CitationImproving preparedness to respond to cross-border hepatitis A outbreaks in the European Union/European Economic Area: towards comparable sequencing of hepatitis A virus. 2019, 24(28). doi: 10.2807/1560-7917.ES.2019.24.28.1800397 Euro Surveill
AbstractIntroductionSequence-based typing of hepatitis A virus (HAV) is important for outbreak detection, investigation and surveillance. In 2013, sequencing was central to resolving a large European Union (EU)-wide outbreak related to frozen berries. However, as the sequenced HAV genome regions were only partly comparable between countries, results were not always conclusive.AimThe objective was to gather information on HAV surveillance and sequencing in EU/European Economic Area (EEA) countries to find ways to harmonise their procedures, for improvement of cross-border outbreak responses.MethodsIn 2014, the European Centre for Disease Prevention and Control (ECDC) conducted a survey on HAV surveillance practices in EU/EEA countries. The survey enquired whether a referral system for confirming primary diagnostics of hepatitis A existed as well as a central collection/storage of hepatitis A cases' samples for typing. Questions on HAV sequencing procedures were also asked. Based on the results, an expert consultation proposed harmonised procedures for cross-border outbreak response, in particular regarding sequencing. In 2016, a follow-up survey assessed uptake of suggested methods.ResultsOf 31 EU/EEA countries, 23 (2014) and 27 (2016) participated. Numbers of countries with central collection and storage of HAV positive samples and of those performing sequencing increased from 12 to 15 and 12 to 14 respectively in 2016, with all countries typing an overlapping fragment of 218 nt. However, variation existed in the sequenced genomic regions and their lengths.ConclusionsWhile HAV sequences in EU/EEA countries are comparable for surveillance, collaboration in sharing and comparing these can be further strengthened.
DescriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
- Three simultaneous, food-borne, multi-country outbreaks of hepatitis A virus infection reported in EPIS-FWD in 2013: what does it mean for the European Union?
- Authors: Gossner CM, Severi E
- Issue date: 2014 Oct 30
- Molecular and genomic typing for tuberculosis surveillance: A survey study in 26 European countries.
- Authors: Andrés M, van der Werf MJ, Ködmön C, Albrecht S, Haas W, Fiebig L, Survey study group.
- Issue date: 2019
- Food-borne diseases associated with frozen berries consumption: a historical perspective, European Union, 1983 to 2013.
- Authors: Tavoschi L, Severi E, Niskanen T, Boelaert F, Rizzi V, Liebana E, Gomes Dias J, Nichols G, Takkinen J, Coulombier D
- Issue date: 2015 Jul 23
- Travel-associated hepatitis A in Europe, 2009 to 2015.
- Authors: Beauté J, Westrell T, Schmid D, Müller L, Epstein J, Kontio M, Couturier E, Faber M, Mellou K, Borg ML, Friesema I, Vold L, Severi E
- Issue date: 2018 May
- Hepatitis A outbreak disproportionately affecting men who have sex with men (MSM) in the European Union and European Economic Area, June 2016 to May 2017.
- Authors: Ndumbi P, Freidl GS, Williams CJ, Mårdh O, Varela C, Avellón A, Friesema I, Vennema H, Beebeejaun K, Ngui SL, Edelstein M, Smith-Palmer A, Murphy N, Dean J, Faber M, Wenzel J, Kontio M, Müller L, Midgley SE, Sundqvist L, Ederth JL, Roque-Afonso AM, Couturier E, Klamer S, Rebolledo J, Suin V, Aberle SW, Schmid D, De Sousa R, Augusto GF, Alfonsi V, Del Manso M, Ciccaglione AR, Mellou K, Hadjichristodoulou C, Donachie A, Borg ML, Sočan M, Poljak M, Severi E, Members Of The European Hepatitis A Outbreak Investigation Team.
- Issue date: 2018 Aug