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dc.contributor.authorSchjørring, Olav L
dc.contributor.authorPerner, Anders
dc.contributor.authorWetterslev, Jørn
dc.contributor.authorLange, Theis
dc.contributor.authorKeus, Frederik
dc.contributor.authorLaake, Jon H
dc.contributor.authorOkkonen, Marjatta
dc.contributor.authorSiegemund, Martin
dc.contributor.authorMorgan, Matthew
dc.contributor.authorThormar, Katrin M
dc.contributor.authorRasmussen, Bodil S
dc.date.accessioned2019-09-20T09:34:45Z
dc.date.available2019-09-20T09:34:45Z
dc.date.issued2019-08
dc.date.submitted2019-09
dc.identifier.citationHandling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure. 2019, 63(7):956-965 Acta Anaesthesiol Scanden_US
dc.identifier.issn1399-6576
dc.identifier.pmid30883686
dc.identifier.doi10.1111/aas.13356
dc.identifier.urihttp://hdl.handle.net/2336/621062
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractBACKGROUND: Acutely ill adults with hypoxaemic respiratory failure are at risk of life-threatening hypoxia, and thus oxygen is often administered liberally. Excessive oxygen use may, however, increase the number of serious adverse events, including death. Establishing the optimal oxygenation level is important as existing evidence is of low quality. We hypothesise that targeting an arterial partial pressure of oxygen (PaO2 ) of 8 kPa is superior to targeting a PaO2 of 12 kPa in adult intensive care unit (ICU) patients with acute hypoxaemic respiratory failure. METHODS: The Handling Oxygenation Targets in the ICU (HOT-ICU) trial is an outcome assessment blinded, multicentre, randomised, parallel-group trial targeting PaO2 in acutely ill adults with hypoxaemic respiratory failure within 12 hours after ICU admission. Patients are randomised 1:1 to one of the two PaO2 targets throughout ICU stay until a maximum of 90 days. The primary outcome is 90-day mortality. Secondary outcomes are serious adverse events in the ICU, days alive without organ support and days alive out of hospital in the 90-day period; mortality, health-related quality-of-life at 1-year follow-up as well as 1-year cognitive and pulmonary function in a subgroup; and an overall health economic analysis. To detect or reject a 20% relative risk reduction, we aim to include 2928 patients. An interim analysis is planned after 90-day follow-up of 1464 patients. CONCLUSION: The HOT-ICU trial will test the hypothesis that a lower oxygenation target reduces 90-day mortality compared with a higher oxygenation target in adult ICU patients with acute hypoxaemic respiratory failure.en_US
dc.description.sponsorshipInnovation Fund Denmark Novo Nordisk Foundation Obel Family Foundation Danish Society of Anaesthesia and Intensive Care Medicine ICU Symposium Hindsgavl Regionernes Medicinpuljeen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/full/10.1111/aas.13356en_US
dc.subjectcritical illnessen_US
dc.subjecthyperoxiaen_US
dc.subjecthypoxiaen_US
dc.subjectintensive care unitsen_US
dc.subjectmortalityen_US
dc.subjectoxygen inhalation therapyen_US
dc.subjectpragmatic clinical trialen_US
dc.subjectrandomised controlled trialen_US
dc.subjectrespiratory insufficiencyen_US
dc.subjectSúrefnien_US
dc.subjectGjörgæslaen_US
dc.subject.meshOxygen Inhalation Therapyen_US
dc.subject.meshHypoxiaen_US
dc.subject.meshIntensive Care Unitsen_US
dc.titleHandling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure.en_US
dc.typeArticleen_US
dc.contributor.department1 Department of Anaesthesia and Intensive Care Medicine, Aalborg University Hospital, Aalborg, Denmark. 2 Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. 3 Centre for Research in Intensive Care (CRIC), Copenhagen, Denmark. 4 Department of Intensive Care, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 5 Copenhagen Trial Unit, Department 7812, Centre for Clinical Intervention Research, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. 6 Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark. 7 Center for Statistical Science, Peking University, Peking, China. 8 Department of Critical Care, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. 9 Division of Emergencies and Critical Care, Oslo University Hospital, Rikshospitalet, Oslo, Norway. 10 Department of Perioperative, Intensive Care and Pain Medicine, Helsinki University Hospital, Helsinki, Finland. 11 Department of Anaesthesia and Intensive Care, University Hospital Basel, Basel, Switzerland. 12 Critical Care Research, University Hospital of Wales, Cardiff, UK. 13 Cardiff University School of Medicine, Wales, UK. 14 Department of Anaesthesia and Intensive Care, University Hospital Reykjavik, Landspitali, Reykjavik, Iceland.en_US
dc.identifier.journalActa Anaesthesiologica Scandinavicaen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeAAA12
dc.source.journaltitleActa anaesthesiologica Scandinavica


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