Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Allodji, Rodrigue SHawkins, Mike M
Bright, Chloe J
Fidler-Benaoudia, Miranda M
Winter, David L
Alessi, Daniela
Fresneau, Brice
Journy, Neige
Morsellino, Vera
Bárdi, Edit
Bautz, Andrea
Byrne, Julianne
Feijen, Elizabeth Lieke Am
Teepen, Jop C
Vu-Bezin, Giao
Rubino, Carole
Garwicz, Stanislaw
Grabow, Desiree
Gudmundsdottir, Thorgerdur
Guha, Joyeeta
Hau, Eva-Maria
Jankovic, Momcilo
Kaatsch, Peter
Kaiser, Melanie
Linge, Helena
Muraca, Monica
Llanas, Damien
Veres, Cristina
Øfstaas, Hilde
Diallo, Ibrahima
Mansouri, Imene
Ronckers, Cecile M
Skinner, Roderick
Terenziani, Monica
Wesenberg, Finn
Wiebe, Thomas
Sacerdote, Carlotta
Jakab, Zsuzsanna
Haupt, Riccardo
Lähteenmäki, Päivi
Zaletel, Lorna Zadravec
Kuehni, Claudia E
Winther, Jeanette F
Michel, Gisela
Kremer, Leontien C M
Hjorth, Lars
Haddy, Nadia
De Vathaire, Florent
Reulen, Raoul C
Issue Date
2019-08
Metadata
Show full item recordCitation
Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup. 2019, 117: 71-83 Eur J CancerAbstract
BACKGROUND: Survivors of childhood cancers are at risk of developing subsequent primary leukaemias (SPLs), but the long-term risks beyond 20 years of treatment are still unclear. We investigated the risk of SPLs in five-year childhood cancer survivors using a large-scale pan-European (PanCareSurFup) cohort and evaluated variations in the risk by cancer and demographic factors. METHODS: This largest-ever assembled cohort comprises 69,460 five-year childhood cancer survivors from 12 European countries. Standardised incidence ratios (SIRs) and absolute excess risks (AERs) were calculated. RESULTS: One hundred fifteen survivors developed an SPL including 86 myeloid leukaemias (subsequent primary myeloid leukaemias [SPMLs]), 17 lymphoid leukaemias and 12 other types of leukaemias; of these SPLs, 31 (27%) occurred beyond 20 years from the first childhood cancer diagnosis. Compared with the general population, childhood cancer survivors had a fourfold increased risk (SIR = 3.7, 95% confidence interval [CI]: 3.1 to 4.5) of developing leukaemia, and eight leukaemias per 100,000 person-years (AER = 7.5, 95% CI: 6.0 to 9.2) occurred in excess of that expected. The risks remained significantly elevated beyond 20 years from the first primary malignancy (SIR = 2.4, 95% CI: 1.6 to 3.4). Overall, the risk ratio for SPML (SIR = 5.8, 95% CI: 4.6 to 7.1) was higher than that for other SPLs. CONCLUSIONS: We demonstrate that beyond 20 years after childhood cancer diagnosis, survivors experience an increased risk for SPLs compared with that expected from the general population. Our findings highlight the need for awareness by survivors and their healthcare providers for potential risk related to SPL.Description
To access publisher's full text version of this article click on the hyperlink belowAdditional Links
https://www.sciencedirect.com/science/article/pii/S0959804919303168ae974a485f413a2113503eed53cd6c53
10.1016/j.ejca.2019.05.013
Scopus Count
Collections
Related articles
- Risk of Soft-Tissue Sarcoma Among 69 460 Five-Year Survivors of Childhood Cancer in Europe.
- Authors: Bright CJ, Hawkins MM, Winter DL, Alessi D, Allodji RS, Bagnasco F, Bárdi E, Bautz A, Byrne J, Feijen EAM, Fidler MM, Garwicz S, Grabow D, Gudmundsdottir T, Guha J, Haddy N, Jankovic M, Kaatsch P, Kaiser M, Kuehni CE, Linge H, Øfstaas H, Ronckers CM, Skinner R, Teepen JC, Terenziani M, Vu-Bezin G, Wesenberg F, Wiebe T, Sacerdote C, Jakab Z, Haupt R, Lähteenmäki P, Zaletel LZ, Kuonen R, Winther JF, de Vathaire F, Kremer LC, Hjorth L, Reulen RC, PanCareSurFup Consortium.
- Issue date: 2018 Jun 1
- Risk of a second malignant neoplasm among 5-year survivors of cancer in childhood and adolescence in British Columbia, Canada.
- Authors: MacArthur AC, Spinelli JJ, Rogers PC, Goddard KJ, Phillips N, McBride ML
- Issue date: 2007 Apr
- Long-term risks of subsequent primary neoplasms among survivors of childhood cancer.
- Authors: Reulen RC, Frobisher C, Winter DL, Kelly J, Lancashire ER, Stiller CA, Pritchard-Jones K, Jenkinson HC, Hawkins MM, British Childhood Cancer Survivor Study Steering Group.
- Issue date: 2011 Jun 8
- Second primary cancers in people who had cancer as children: an Australian Childhood Cancer Registry population-based study.
- Authors: Youlden DR, Baade PD, Green AC, Valery PC, Moore AS, Aitken JF
- Issue date: 2020 Feb
- Italian cancer figures, report 2013: Multiple tumours.
- Authors: AIRTUM Working Group.
- Issue date: 2013 Jul-Oct