Show simple item record

dc.contributor.authorHalldorsson, Matthias Orn
dc.contributor.authorHauptmann, Michael
dc.contributor.authorSnaebjornsson, Petur
dc.contributor.authorHaraldsdóttir, Kristín Huld
dc.contributor.authorAspelund, Thor
dc.contributor.authorGudmundsson, Elias Freyr
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorJonasson, Jon Gunnlaugur
dc.contributor.authorHaraldsdottir, Sigurdis
dc.date.accessioned2019-09-30T14:43:58Z
dc.date.available2019-09-30T14:43:58Z
dc.date.issued2018-08
dc.date.submitted2019-09
dc.identifier.citationThe risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy. 2019, 53(8):972-975 Scand J Gastroenterolen_US
dc.identifier.issn1502-7708
dc.identifier.pmid30010450
dc.identifier.doi10.1080/00365521.2018.1481997
dc.identifier.urihttp://hdl.handle.net/2336/621086
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractOBJECTIVES: Mismatch repair deficient (dMMR) colorectal cancer (CRC) is caused by inactivation of the MMR DNA repair system, most commonly via epigenetic inactivation of the MLH1 gene, and these tumors occur most frequently in the right colon. The objective was to determine whether cholecystectomy (CCY) increases the risk of a dMMR CRC by comparing CCY incidence in patients with dMMR CRC and proficient MMR (pMMR) CRC to unaffected controls. MATERIALS AND METHODS: All patients diagnosed with CRC in Iceland from 2000 to 2009 (n = 1171) were included. They had previously been screened for dMMR by immunohistochemistry (n = 129 were dMMR). Unaffected age- and sex-matched controls (n = 17,460) were obtained from large Icelandic cohort studies. Subjects were cross-referenced with all pathology databases in Iceland to establish who had undergone CCY. Odds ratios were calculated using unconditional logistic regression. RESULTS: Eighteen (13.7%) dMMR CRC cases and 90 (8.7%) pMMR CRC cases had undergone CCY compared to 1532 (8.8%) controls. CCY-related odds ratios (OR) were 1.06 (95% CI 0.90-1.26, p = .577) for all CRC, 1.16 (95% CI 0.66-2.05 p = .602) for dMMR CRCand 1.04 (95% CI 0.83-1.29, p = .744) for pMMR CRC. Furthermore, OR for dMMR CRC was 0.51 (95% CI 0.16-1.67, p = .266), 2.04 (95% CI 0.92-4.50, p = .080) and 1.08 (95% CI 0.40-2.89, p = .875) <10 years, 10-20 years and >20 years after a CCY, respectively. CONCLUSIONS: There was no evidence of increased risk of developing dMMR CRC after CCY although a borderline significantly increased 2-fold risk was observed 10-20 years after CCY. Larger studies are warranted to examine this further.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.urlhttps://www.tandfonline.com/doi/full/10.1080/00365521.2018.1481997en_US
dc.subjectMLH1 hypermethylationen_US
dc.subjectMicrosatellite instabilityen_US
dc.subjectcarcinogenesis of bile acidsen_US
dc.subjectcholecystectomyen_US
dc.subjectcolorectal cancer risk factorsen_US
dc.subjectpopulation-baseden_US
dc.subjectRistilkrabbameinen_US
dc.subjectGallblöðrunámen_US
dc.subject.meshColorectal Neoplasmsen_US
dc.subject.meshCholecystectomyen_US
dc.titleThe risk of developing a mismatch repair deficient colorectal cancer after undergoing cholecystectomy.en_US
dc.typeArticleen_US
dc.contributor.departmenta Faculty of Medicine , University of Iceland , Reykjavík , Iceland. 2 b Department of Epidemiology and Biostatistics , The Netherlands Cancer Institute , Amsterdam , The Netherlands. 3 c Department of Pathology , The Netherlands Cancer Institute , Amsterdam , The Netherlands. 4 d Landspitali University Hospital Iceland , Reykjavík , Iceland. 5 e University of Iceland , Reykjavík , Iceland. 6 f Icelandic Heart Association , Kópavogur , Iceland. 7 g Department of Pathology , Landspitali-University Hospital , Iceland. 8 h Department of Internal Medicine , Stanford University , Stanford , CA , USA.en_US
dc.identifier.journalScandinavian Journal of Gastroenterologyen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodeSAM12
dc.departmentcodePTT12
dc.source.journaltitleScandinavian journal of gastroenterology


This item appears in the following Collection(s)

Show simple item record