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dc.contributor.authorTeumer, Alexander
dc.contributor.authorLi, Yong
dc.contributor.authorGhasemi, Sahar
dc.contributor.authorPrins, Bram P
dc.contributor.authorWuttke, Matthias
dc.contributor.authorHermle, Tobias
dc.contributor.authorGiri, Ayush
dc.contributor.authorSieber, Karsten B
dc.contributor.authorQiu, Chengxiang
dc.contributor.authorKirsten, Holger
dc.contributor.authorTin, Adrienne
dc.contributor.authorChu, Audrey Y
dc.contributor.authorBansal, Nisha
dc.contributor.authorFeitosa, Mary F
dc.contributor.authorWang, Lihua
dc.contributor.authorChai, Jin-Fang
dc.contributor.authorCocca, Massimiliano
dc.contributor.authorFuchsberger, Christian
dc.contributor.authorGorski, Mathias
dc.contributor.authorHoppmann, Anselm
dc.contributor.authorHorn, Katrin
dc.contributor.authorLi, Man
dc.contributor.authorMarten, Jonathan
dc.contributor.authorNoce, Damia
dc.contributor.authorNutile, Teresa
dc.contributor.authorSedaghat, Sanaz
dc.contributor.authorSveinbjornsson, Gardar
dc.contributor.authorTayo, Bamidele O
dc.contributor.authorvan der Most, Peter J
dc.contributor.authorXu, Yizhe
dc.contributor.authorYu, Zhi
dc.contributor.authorGerstner, Lea
dc.contributor.authorÄrnlöv, Johan
dc.contributor.authorBakker, Stephan J L
dc.contributor.authorBaptista, Daniela
dc.contributor.authorBiggs, Mary L
dc.contributor.authorBoerwinkle, Eric
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBurkhardt, Ralph
dc.contributor.authorCarroll, Robert J
dc.contributor.authorChee, Miao-Li
dc.contributor.authorChee, Miao-Ling
dc.contributor.authorChen, Mengmeng
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorCook, James P
dc.contributor.authorCoresh, Josef
dc.contributor.authorCorre, Tanguy
dc.contributor.authorDanesh, John
dc.contributor.authorde Borst, Martin H
dc.contributor.authorDe Grandi, Alessandro
dc.contributor.authorde Mutsert, Renée
dc.contributor.authorde Vries, Aiko P J
dc.contributor.authorDegenhardt, Frauke
dc.contributor.authorDittrich, Katalin
dc.contributor.authorDivers, Jasmin
dc.contributor.authorEckardt, Kai-Uwe
dc.contributor.authorEhret, Georg
dc.contributor.authorEndlich, Karlhans
dc.contributor.authorFelix, Janine F
dc.contributor.authorFranco, Oscar H
dc.contributor.authorFranke, Andre
dc.contributor.authorFreedman, Barry I
dc.contributor.authorFreitag-Wolf, Sandra
dc.contributor.authorGansevoort, Ron T
dc.contributor.authorGiedraitis, Vilmantas
dc.contributor.authorGögele, Martin
dc.contributor.authorGrundner-Culemann, Franziska
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHamet, Pavel
dc.contributor.authorHarris, Tamara B
dc.contributor.authorHicks, Andrew A
dc.contributor.authorHolm, Hilma
dc.contributor.authorFoo, Valencia Hui Xian
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorIkram, M Arfan
dc.contributor.authorIngelsson, Erik
dc.contributor.authorJaddoe, Vincent W V
dc.contributor.authorJakobsdottir, Johanna
dc.contributor.authorJosyula, Navya Shilpa
dc.contributor.authorJung, Bettina
dc.contributor.authorKähönen, Mika
dc.contributor.authorKhor, Chiea-Chuen
dc.contributor.authorKiess, Wieland
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorKörner, Antje
dc.contributor.authorKovacs, Peter
dc.contributor.authorKramer, Holly
dc.contributor.authorKrämer, Bernhard K
dc.contributor.authorKronenberg, Florian
dc.contributor.authorLange, Leslie A
dc.contributor.authorLangefeld, Carl D
dc.contributor.authorLee, Jeannette Jen-Mai
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLieb, Wolfgang
dc.contributor.authorLim, Su-Chi
dc.contributor.authorLind, Lars
dc.contributor.authorLindgren, Cecilia M
dc.contributor.authorLiu, Jianjun
dc.contributor.authorLoeffler, Markus
dc.contributor.authorLyytikäinen, Leo-Pekka
dc.contributor.authorMahajan, Anubha
dc.contributor.authorMaranville, Joseph C
dc.contributor.authorMascalzoni, Deborah
dc.contributor.authorMcMullen, Barbara
dc.contributor.authorMeisinger, Christa
dc.contributor.authorMeitinger, Thomas
dc.contributor.authorMiliku, Kozeta
dc.contributor.authorMook-Kanamori, Dennis O
dc.contributor.authorMüller-Nurasyid, Martina
dc.contributor.authorMychaleckyj, Josyf C
dc.contributor.authorNauck, Matthias
dc.contributor.authorNikus, Kjell
dc.contributor.authorNing, Boting
dc.contributor.authorNoordam, Raymond
dc.contributor.authorConnell, Jeffrey O'
dc.contributor.authorOlafsson, Isleifur
dc.contributor.authorPalmer, Nicholette D
dc.contributor.authorPeters, Annette
dc.contributor.authorPodgornaia, Anna I
dc.contributor.authorPonte, Belen
dc.contributor.authorPoulain, Tanja
dc.contributor.authorPramstaller, Peter P
dc.contributor.authorRabelink, Ton J
dc.contributor.authorRaffield, Laura M
dc.contributor.authorReilly, Dermot F
dc.contributor.authorRettig, Rainer
dc.contributor.authorRheinberger, Myriam
dc.contributor.authorRice, Kenneth M
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorRunz, Heiko
dc.contributor.authorRyan, Kathleen A
dc.contributor.authorSabanayagam, Charumathi
dc.contributor.authorSaum, Kai-Uwe
dc.contributor.authorSchöttker, Ben
dc.contributor.authorShaffer, Christian M
dc.contributor.authorShi, Yuan
dc.contributor.authorSmith, Albert V
dc.contributor.authorStrauch, Konstantin
dc.contributor.authorStumvoll, Michael
dc.contributor.authorSun, Benjamin B
dc.contributor.authorSzymczak, Silke
dc.contributor.authorTai, E-Shyong
dc.contributor.authorTan, Nicholas Y Q
dc.contributor.authorTaylor, Kent D
dc.contributor.authorTeren, Andrej
dc.contributor.authorTham, Yih-Chung
dc.contributor.authorThiery, Joachim
dc.contributor.authorThio, Chris H L
dc.contributor.authorThomsen, Hauke
dc.contributor.authorThorsteinsdottir, Unnur
dc.contributor.authorTönjes, Anke
dc.contributor.authorTremblay, Johanne
dc.contributor.authorUitterlinden, André G
dc.contributor.authorvan der Harst, Pim
dc.contributor.authorVerweij, Niek
dc.contributor.authorVogelezang, Suzanne
dc.contributor.authorVölker, Uwe
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorWang, Chaolong
dc.contributor.authorWilson, Otis D
dc.contributor.authorWong, Charlene
dc.contributor.authorWong, Tien-Yin
dc.contributor.authorYang, Qiong
dc.contributor.authorYasuda, Masayuki
dc.contributor.authorAkilesh, Shreeram
dc.contributor.authorBochud, Murielle
dc.contributor.authorBöger, Carsten A
dc.contributor.authorDevuyst, Olivier
dc.contributor.authorEdwards, Todd L
dc.contributor.authorHo, Kevin
dc.contributor.authorMorris, Andrew P
dc.contributor.authorParsa, Afshin
dc.contributor.authorPendergrass, Sarah A
dc.contributor.authorPsaty, Bruce M
dc.contributor.authorRotter, Jerome I
dc.contributor.authorStefansson, Kari
dc.contributor.authorWilson, James G
dc.contributor.authorSusztak, Katalin
dc.contributor.authorSnieder, Harold
dc.contributor.authorHeid, Iris M
dc.contributor.authorScholz, Markus
dc.contributor.authorButterworth, Adam S
dc.contributor.authorHung, Adriana M
dc.contributor.authorPattaro, Cristian
dc.contributor.authorKöttgen, Anna
dc.date.accessioned2019-10-18T13:17:14Z
dc.date.available2019-10-18T13:17:14Z
dc.date.issued2019-09-11
dc.date.submitted2019-10
dc.identifier.citationGenome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria. 2019, 10(1):4130 Nat Communen_US
dc.identifier.issn2041-1723
dc.identifier.pmid31511532
dc.identifier.doi10.1038/s41467-019-11576-0
dc.identifier.urihttp://hdl.handle.net/2336/621103
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractIncreased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. Genetic correlation analyses and risk score associations in an independent electronic medical records database (n = 192,868) reveal connections with proteinuria, hyperlipidemia, gout, and hypertension. Fine-mapping and trans-Omics analyses with gene expression in 47 tissues and plasma protein levels implicate genes potentially operating through differential expression in kidney (including TGFB1, MUC1, PRKCI, and OAF), and allow coupling of UACR associations to altered plasma OAF concentrations. Knockdown of OAF and PRKCI orthologs in Drosophila nephrocytes reduces albumin endocytosis. Silencing fly PRKCI further impairs slit diaphragm formation. These results generate a priority list of genes and pathways for translational research to reduce albuminuria.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.urlhttps://www.nature.com/articles/s41467-019-11576-0en_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739370/en_US
dc.subjectNýrnasjúkdómaren_US
dc.subjectPrótínen_US
dc.subjectÞvagen_US
dc.subject.meshAlbuminuriaen_US
dc.subject.meshKidney Diseasesen_US
dc.titleGenome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.en_US
dc.typeArticleen_US
dc.contributor.department1 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 2 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. ateumer@uni-greifswald.de. 3 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 4 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. 5 DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. 6 MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 7 Renal Division, Department of Medicine, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. 8 Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. 9 Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 10 Target Sciences - Genetics, GlaxoSmithKline, Collegeville, PA, USA. 11 Renal Electrolyte and Hypertension Division, Department of Medicine, Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. 12 Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 13 LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. 14 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 15 Epidemiology and Clinical Research, Welch Centre for Prevention, Baltimore, MD, USA. 16 Genetics, Merck & Co., Inc., Kenilworth, NJ, USA. 17 Division of Nephrology, University of Washington, Seattle, WA, USA. 18 Kidney Research Institute, University of Washington, Seattle, WA, USA. 19 Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. 20 Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. 21 Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy. 22 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. 23 Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. 24 Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. 25 Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. 26 Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. 27 Institute of Genetics and Biophysics "Adriano Buzzati-Traverso" - CNR, Naples, Italy. 28 Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 29 deCODE Genetics, Amgen Inc., Reykjavik, Iceland. 30 Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. 31 Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 32 Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. 33 Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden. 34 School of Health and Social Studies, Dalarna University, Falun, Sweden. 35 Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 36 Cardiology, Geneva University Hospitals, Geneva, Switzerland. 37 Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. 38 Department of Biostatistics, University of Washington, Seattle, WA, USA. 39 Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA. 40 Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 41 Network Aging Research, University of Heidelberg, Heidelberg, Germany. 42 Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. 43 Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. 44 Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. 45 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. 46 Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. 47 Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 48 Department of Biostatistics, University of Liverpool, Liverpool, UK. 49 Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. 50 Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. 51 Swiss Institute of Bioinformatics, Lausanne, Switzerland. 52 Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 53 Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands. 54 Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 55 Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany. 56 Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. 57 Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. 58 Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA. 59 Intensive Care Medicine, Charité, Berlin, Germany. 60 Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany. 61 Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. 62 The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 63 Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 64 Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland. 65 Internal Medicine - Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, NC, USA. 66 Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, USA. 67 Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden. 68 Icelandic Heart Association, Kopavogur, Iceland. 69 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. 70 Montreal University Hospital Research Centre, CHUM, Montreal, QC, Canada. 71 Medpharmgene, Montreal, QC, Canada. 72 Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. 73 NHLBI's Framingham Heart Study, Framingham, MA, USA. 74 The Centre for Population Studies, NHLBI, Framingham, MA, USA. 75 Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. 76 Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. 77 Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 78 Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. 79 Icelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland. 80 The Centre of Public Health Sciences, University of Iceland, Sturlugata 8, Reykjavík, IS-101, Iceland. 81 Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. 82 Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. 83 Department of Clinical Physiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 84 Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. 85 Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. 86 DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. 87 Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. 88 Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany. 89 Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA. 90 5th Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. 91 Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. 92 Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver - Anschutz Medical Campus, Aurora, CO, USA. 93 Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. 94 Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 95 Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany. 96 Diabetes Centre, Khoo Teck Puat Hospital, Singapore, Singapore. 97 Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 98 Nuffield Department of Medicine, University of Oxford, Oxford, UK. 99 Broad Institute of Harvard and MIT, Cambridge, MA, USA. 100 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. 101 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. 102 Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. 103 MRL, Merck & Co., Inc., Kenilworth, NJ, USA. 104 Celgene Inc., Cambridge, MA, USA. 105 Vanderbilt University School of Medicine, Nashville, TN, USA. 106 Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. 107 Chair of Epidemiology Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. 108 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. 109 Institute of Human Genetics, Technische Universität München, Munich, Germany. 110 Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, The Netherlands. 111 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 112 Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany. 113 Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany. 114 Centre for Public Health Genomics, University of Virginia, Charlottesville, VA, USA. 115 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. 116 Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. 117 Department of Cardiology, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. 118 Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 119 Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, The Netherlands. 120 University of Maryland School of Medicine, Baltimore, MD, USA. 121 Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. 122 Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA. 123 Institute of Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 124 German Center for Diabetes Research (DZD), Neuherberg, Germany. 125 Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland. 126 Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, The Netherlands. 127 Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. 128 Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. 129 Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. 130 Biogen Inc., Cambridge, MA, USA. 131 Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. 132 Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. 133 Duke-NUS Medical School, Singapore, Singapore. 134 The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. 135 Heart Centre Leipzig, Leipzig, Germany. 136 Division of Molecular Genetic Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany. 137 CRCHUM, Montreal, QC, Canada. 138 Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 139 Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. 140 Durrer Centre for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, The Netherlands. 141 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. 142 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Centre for Environmental Health, Neuherberg, Germany. 143 School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 144 Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. 145 Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan. 146 Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA. 147 Department of Nephrology, Diabetology and Rheumatology, Kliniken Südostbayern, Traunstein, Germany. 148 Institute of Physiology, University of Zurich, Zurich, Switzerland. 149 Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA. 150 Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. 151 Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. 152 Department of Nephrology, Geisinger, Danville, PA, USA. 153 Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. 154 Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. 155 Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. 156 Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. 157 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. 158 Department of Pediatrics, Harbor-UCLA Medical Centre, Torrance, CA, USA. 159 Department of Medicine, Harbor-UCLA Medical Centre, Torrance, CA, USA. 160 Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA. 161 National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. 162 Eurac Research, Institute for Biomedicine (affiliated to the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu. 163 Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. 164 Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.deen_US
dc.identifier.journalNature Communicationsen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeMAB12
dc.source.journaltitleNature communications
refterms.dateFOA2019-10-18T13:17:15Z


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