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Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program.

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Authors
Norsker, Filippa Nyboe
Rechnitzer, Catherine
Andersen, Elisabeth Wreford
Linnet, Karen Markussen
Kenborg, Line
Holmqvist, Anna Sällfors
Tryggvadottir, Laufey
Madanat-Harjuoja, Laura-Maria
Øra, Ingrid
Thorarinsdottir, Halldora K
Vettenranta, Kim
Bautz, Andrea
Schrøder, Henrik
Hasle, Henrik
Winther, Jeanette Falck
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Issue Date
2019-10-08

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Neurologic disorders in long-term survivors of neuroblastoma - a population-based cohort study within the Adult Life after Childhood Cancer in Scandinavia (ALiCCS) research program. 2019, 1-7. doi: 10.1080/0284186X.2019.1672892 Acta Oncol
Abstract
Background: Neuroblastoma is the commonest extracranial solid tumor of childhood, yet rare, and with poor survival before 1990, especially for high-risk disease; thus, information on late effects is sparse. With great advances in cancer treatment, survival has reached 80% in the Nordic countries. The aim of the study was to investigate the risk of developing neurologic disorders after neuroblastoma. Material and methods: Through population-based cancer registries of four Nordic countries we identified 654 5-year survivors of neuroblastoma (diagnosed 1959-2008) and 133,668 matched population comparisons. We grouped neurologic diagnoses from national hospital registries into 11 main diagnostic categories and 56 disease-specific sub-categories and calculated relative risks (RRs), absolute excess risks (AERs), cumulative incidence and mean cumulative count (MCC). Information on cancer treatment was available for 49% of survivors. Results: A hospital contact for a neurologic disorder was observed in 181 survivors 5 years or more from cancer diagnosis with 59 expected, yielding a RR of 3.1 (95% CI 2.7-3.6) and an AER of 16 per 1,000 person-years (95% CI 12-19). The most frequent disorders included epilepsy, paralytic syndromes, diseases of the eyes and ears and hearing loss. The cumulative incidence of any neurologic disorder was 31% in survivors 20 years after cancer diagnosis with a MCC of 0.5 unique diagnoses. All risks were highest in survivors of high-risk neuroblastoma. Conclusion: Neuroblastoma survivors represent a population with a high risk of developing neurologic disorders. Our results should contribute to improving health care planning and underscores the need for systematic follow-up care of this vulnerable group of survivors.
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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1672892
ae974a485f413a2113503eed53cd6c53
10.1080/0284186X.2019.1672892
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