Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder.
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Authors
Gudmundsson, Olafur OWalters, G Bragi
Ingason, Andres
Johansson, Stefan
Zayats, Tetyana
Athanasiu, Lavinia
Sonderby, Ida Elken
Gustafsson, Omar
Nawaz, Muhammad S
Jonsson, Gudbjorn F
Jonsson, Lina
Knappskog, Per-Morten
Ingvarsdottir, Ester
Davidsdottir, Katrin
Djurovic, Srdjan
Knudsen, Gun Peggy Strømstad
Askeland, Ragna Bugge
Haraldsdottir, Gyda S
Baldursson, Gisli
Magnusson, Pall
Sigurdsson, Engilbert
Gudbjartsson, Daniel F
Stefansson, Hreinn
Andreassen, Ole A
Haavik, Jan
Reichborn-Kjennerud, Ted
Stefansson, Kari
Issue Date
2019-10-17
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Gudmundsson OO, Walters GB, Ingason A, Johansson S, Zayats T, Athanasiu L, Sonderby IE, Gustafsson O, Nawaz MS, Jonsson GF, Jonsson L. Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational psychiatry. 2019 Oct 17;9(1):258. doi: 10.1038/s41398-019-0599-y.Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5-BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10-21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.Description
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https://www.nature.com/articles/s41398-019-0599-yae974a485f413a2113503eed53cd6c53
10.1038/s41398-019-0599-y
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