• English
    • íslenska
  • English 
    • English
    • íslenska
  • Login
View Item 
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
  •   Home
  • Journal Articles, Peer Reviewed (Ritrýndar vísindagreinar)
  • English Journal Articles (Peer Reviewed)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Browse

All of HirslaCommunitiesAuthorsTitleSubjectsSubject (MeSH)Issue DateJournalThis CollectionAuthorsTitleSubjectsSubject (MeSH)Issue DateJournal

My Account

LoginRegister

Local Links

FAQ - (Icelandic)FAQ - (English)Hirsla LogosAbout LandspitaliLSH Home PageLibrary HomeIcelandic Journals

Statistics

Display statistics

Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder.

  • CSV
  • RefMan
  • EndNote
  • BibTex
  • RefWorks
Thumbnail
Name:
Attention-deficit ....pdf
Size:
806.3Kb
Format:
PDF
Download
Average rating
 
   votes
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item. When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
 
Your vote was cast
Thank you for your feedback
Authors
Gudmundsson, Olafur O
Walters, G Bragi
Ingason, Andres
Johansson, Stefan
Zayats, Tetyana
Athanasiu, Lavinia
Sonderby, Ida Elken
Gustafsson, Omar
Nawaz, Muhammad S
Jonsson, Gudbjorn F
Jonsson, Lina
Knappskog, Per-Morten
Ingvarsdottir, Ester
Davidsdottir, Katrin
Djurovic, Srdjan
Knudsen, Gun Peggy Strømstad
Askeland, Ragna Bugge
Haraldsdottir, Gyda S
Baldursson, Gisli
Magnusson, Pall
Sigurdsson, Engilbert
Gudbjartsson, Daniel F
Stefansson, Hreinn
Andreassen, Ole A
Haavik, Jan
Reichborn-Kjennerud, Ted
Stefansson, Kari
Show allShow less
Issue Date
2019-10-17

Metadata
Show full item record
Citation
Gudmundsson OO, Walters GB, Ingason A, Johansson S, Zayats T, Athanasiu L, Sonderby IE, Gustafsson O, Nawaz MS, Jonsson GF, Jonsson L. Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational psychiatry. 2019 Oct 17;9(1):258. doi: 10.1038/s41398-019-0599-y.
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5-BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10-21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.
Description
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
Additional Links
https://www.nature.com/articles/s41398-019-0599-y
ae974a485f413a2113503eed53cd6c53
10.1038/s41398-019-0599-y
Scopus Count
Collections
English Journal Articles (Peer Reviewed)

entitlement

Related articles

  • Genotype-phenotype associations in children with copy number variants associated with high neuropsychiatric risk in the UK (IMAGINE-ID): a case-control cohort study.
  • Authors: Chawner SJRA, Owen MJ, Holmans P, Raymond FL, Skuse D, Hall J, van den Bree MBM
  • Issue date: 2019 Jun
  • Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis.
  • Authors: Williams NM, Zaharieva I, Martin A, Langley K, Mantripragada K, Fossdal R, Stefansson H, Stefansson K, Magnusson P, Gudmundsson OO, Gustafsson O, Holmans P, Owen MJ, O'Donovan M, Thapar A
  • Issue date: 2010 Oct 23
  • Association of copy number variation across the genome with neuropsychiatric traits in the general population.
  • Authors: Guyatt AL, Stergiakouli E, Martin J, Walters J, O'Donovan M, Owen M, Thapar A, Kirov G, Rodriguez S, Rai D, Zammit S, Gaunt TR
  • Issue date: 2018 Jul
  • A brief report: de novo copy number variants in children with attention deficit hyperactivity disorder.
  • Authors: Martin J, Hosking G, Wadon M, Agha SS, Langley K, Rees E, Owen MJ, O'Donovan M, Kirov G, Thapar A
  • Issue date: 2020 May 12
  • Psychiatric Polygenic Risk Scores as Predictor for Attention Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in a Clinical Child and Adolescent Sample.
  • Authors: Jansen AG, Dieleman GC, Jansen PR, Verhulst FC, Posthuma D, Polderman TJC
  • Issue date: 2020 Jul

DSpace software (copyright © 2002 - 2022)  DuraSpace
Quick Guide | Contact Us
Open Repository is a service operated by 
Atmire NV
 

Export search results

The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.