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dc.contributor.authorGudmundsson, Olafur O
dc.contributor.authorWalters, G Bragi
dc.contributor.authorIngason, Andres
dc.contributor.authorJohansson, Stefan
dc.contributor.authorZayats, Tetyana
dc.contributor.authorAthanasiu, Lavinia
dc.contributor.authorSonderby, Ida Elken
dc.contributor.authorGustafsson, Omar
dc.contributor.authorNawaz, Muhammad S
dc.contributor.authorJonsson, Gudbjorn F
dc.contributor.authorJonsson, Lina
dc.contributor.authorKnappskog, Per-Morten
dc.contributor.authorIngvarsdottir, Ester
dc.contributor.authorDavidsdottir, Katrin
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorKnudsen, Gun Peggy Strømstad
dc.contributor.authorAskeland, Ragna Bugge
dc.contributor.authorHaraldsdottir, Gyda S
dc.contributor.authorBaldursson, Gisli
dc.contributor.authorMagnusson, Pall
dc.contributor.authorSigurdsson, Engilbert
dc.contributor.authorGudbjartsson, Daniel F
dc.contributor.authorStefansson, Hreinn
dc.contributor.authorAndreassen, Ole A
dc.contributor.authorHaavik, Jan
dc.contributor.authorReichborn-Kjennerud, Ted
dc.contributor.authorStefansson, Kari
dc.date.accessioned2019-11-19T10:21:15Z
dc.date.available2019-11-19T10:21:15Z
dc.date.issued2019-10-17
dc.date.submitted2019-11
dc.identifier.citationGudmundsson OO, Walters GB, Ingason A, Johansson S, Zayats T, Athanasiu L, Sonderby IE, Gustafsson O, Nawaz MS, Jonsson GF, Jonsson L. Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder. Translational psychiatry. 2019 Oct 17;9(1):258. doi: 10.1038/s41398-019-0599-y.en_US
dc.identifier.issn2158-3188
dc.identifier.pmid31624239
dc.identifier.doi10.1038/s41398-019-0599-y
dc.identifier.urihttp://hdl.handle.net/2336/621181
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5-BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10-21), even when comorbid ASD and schizophrenia are excluded from the sample. These results highlight the pleiotropic effect of the neuropsychiatric CNVs and add evidence for ADHD, ASD and schizophrenia being related neurodevelopmental disorders rather than distinct entities.en_US
dc.description.sponsorshipInnovative Medicines Initiative Joint Undertaking from the European Union's Seventh Framework Programme (EU-FP7/2007-2013) European Union (EU) EU-FP7-People-2011-IAPP grant Research Council of Norway KG Jebsen Stiftelsen South-East Norway Health Authorityen_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.urlhttps://www.nature.com/articles/s41398-019-0599-yen_US
dc.subjectADHDen_US
dc.subjectGeðsjúkdómaren_US
dc.subjectEinhverfaen_US
dc.subjectGenen_US
dc.subject.meshAttention Deficit Disorder with Hyperactivityen_US
dc.subject.meshMental Disordersen_US
dc.subject.meshGeneticsen_US
dc.subject.meshAutism Spectrum Disorderen_US
dc.titleAttention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder.en_US
dc.typeArticleen_US
dc.contributor.department1 deCODE genetics/Amgen, Reykjavík, Iceland. 2 Faculty of Medicine, University of Iceland, Reykjavík, Iceland. 3 Department of Child and Adolescent Psychiatry, National University Hospital, Reykjavik, Iceland. 4 Department of Clinical Science, University of Bergen, Bergen, Norway. 5 Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway. 6 K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway. 7 NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. 8 Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. 9 The Centre for Child Development and Behaviour, Capital Area Primary Health Care, Reykjavik, Iceland. 10 Department of Medical Genetics, Oslo University Hospital, Kirkeveien 166, 424, Oslo, Norway. 11 Department of Mental Disorders, Norwegian Institute of Public Health, P. O. Box 4404 Nydalen, 0403, Oslo, Norway. 12 Department of Psychiatry, National University Hospital, Reykjavík, Iceland. 13 School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland. 14 deCODE genetics/Amgen, Reykjavík, Iceland. hreinn@decode.is. 15 Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. 16 Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 17 deCODE genetics/Amgen, Reykjavík, Iceland. kstefans@decode.is. 18 Faculty of Medicine, University of Iceland, Reykjavík, Iceland. kstefans@decode.is.en_US
dc.identifier.journalTranslational Psychiatryen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.type.categoryhttps://www.nature.com/articles/s41398-019-0599-yen_US
dc.departmentcodePSY12
dc.departmentcodePSC12
dc.departmentcodeBUG12
dc.source.journaltitleTranslational psychiatry
refterms.dateFOA2019-11-19T10:22:12Z


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