Sequence variants with large effects on cardiac electrophysiology and disease.
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Norland, KristjanSveinbjornsson, Gardar
Thorolfsdottir, Rosa B
Davidsson, Olafur B
Tragante, Vinicius
Rajamani, Sridharan
Helgadottir, Anna
Gretarsdottir, Solveig
van Setten, Jessica
Asselbergs, Folkert W
Sverrisson, Jon Th
Stephensen, Sigurdur S
Oskarsson, Gylfi
Sigurdsson, Emil L
Andersen, Karl
Danielsen, Ragnar
Thorgeirsson, Gudmundur
Thorsteinsdottir, Unnur
Arnar, David O
Sulem, Patrick
Holm, Hilma
Gudbjartsson, Daniel F
Stefansson, Kari
Issue Date
2019-10-22
Metadata
Show full item recordCitation
Norland, K., Sveinbjornsson, G., Thorolfsdottir, R.B. et al. Sequence variants with large effects on cardiac electrophysiology and disease. Nat Commun 10, 4803 (2019) doi:10.1038/s41467-019-12682-9Abstract
Features of the QRS complex of the electrocardiogram, reflecting ventricular depolarisation, associate with various physiologic functions and several pathologic conditions. We test 32.5 million variants for association with ten measures of the QRS complex in 12 leads, using 405,732 electrocardiograms from 81,192 Icelanders. We identify 190 associations at 130 loci, the majority of which have not been reported before, including associations with 21 rare or low-frequency coding variants. Assessment of genes expressed in the heart yields an additional 13 rare QRS coding variants at 12 loci. We find 51 unreported associations between the QRS variants and echocardiographic traits and cardiovascular diseases, including atrial fibrillation, complete AV block, heart failure and supraventricular tachycardia. We demonstrate the advantage of in-depth analysis of the QRS complex in conjunction with other cardiovascular phenotypes to enhance our understanding of the genetic basis of myocardial mass, cardiac conduction and disease.Description
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadAdditional Links
https://www.nature.com/articles/s41467-019-12682-9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6805929/
ae974a485f413a2113503eed53cd6c53
10.1038/s41467-019-12682-9
Scopus Count
Collections
Related articles
- [ATRIAL FIBRILLATION AND HEMODINAMICALY UNSTABLE WIDE QRS COMPLEX TACHYCARDIA – A case report].
- Authors: Puljević M, Velagić V, Pezo-Nikolić B, Puljević D
- Issue date: 2016 Sep-Oct
- Several common variants modulate heart rate, PR interval and QRS duration.
- Authors: Holm H, Gudbjartsson DF, Arnar DO, Thorleifsson G, Thorgeirsson G, Stefansdottir H, Gudjonsson SA, Jonasdottir A, Mathiesen EB, Njølstad I, Nyrnes A, Wilsgaard T, Hald EM, Hveem K, Stoltenberg C, Løchen ML, Kong A, Thorsteinsdottir U, Stefansson K
- Issue date: 2010 Feb
- [Analysis of changes in repolarization for the differential diagnosis of narrow QRS supraventricular tachycardia and the site of the accessory pathway].
- Authors: Fassini G, Riva S, Della Bella P, Carbucicchio C, Tondo C
- Issue date: 1996 Sep
- Wide QRS complex tachycardia: ECG differential diagnosis.
- Authors: Brady WJ, Skiles J
- Issue date: 1999 Jul
- Intravenous adenosine triphosphate during wide QRS complex tachycardia: safety, therapeutic efficacy, and diagnostic utility.
- Authors: Sharma AD, Klein GJ, Yee R
- Issue date: 1990 Apr