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dc.contributor.authorSchote, Andrea B
dc.contributor.authorBonenberger, Martina
dc.contributor.authorPálmason, Haukur
dc.contributor.authorSeitz, Christiane
dc.contributor.authorMeyer, Jobst
dc.contributor.authorFreitag, Christine M
dc.date.accessioned2019-12-17T15:12:57Z
dc.date.available2019-12-17T15:12:57Z
dc.date.issued2016-12
dc.date.submitted2019-12
dc.identifier.citationSchote AB, Bonenberger M, Pálmason H, Seitz C, Meyer J, Freitag CM. Glucocorticoid receptor variants in childhood attention-deficit/hyperactivity disorder and comorbid psychiatric disorders. Psychiatry research. 2016 Dec 30;246:275-83.en_US
dc.identifier.pmid27741480
dc.identifier.doi10.1016/j.psychres.2016.10.001
dc.identifier.urihttp://hdl.handle.net/2336/621241
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractStress results in a variety of neuroendocrine, immune and behavioral responses and represents a risk factor for many disorders. Following exposure to stress, glucocorticoids are secreted from the adrenal cortex and act via the ligand-activated glucocorticoid receptor (GR). Several polymorphisms of the GR-encoding gene NR3C1 have been described and functionally investigated. However, the impact of these variants on complex diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD) is still unclear. In this study, 251 children with ADHD, 19 affected and 35 unaffected siblings, and their parents were included in a family-based association study assessing seven common variants of NR3C1 (TthIIII_rs10052957; NR3C1-I_rs10482605; ER22/23EK_rs6189/rs6190; N363S_rs56149945; BclI_rs41423247; GR-9beta_rs6198). A four-marker haplotype (TthIIII-NR3C1-I-ER22/23EK) was nominally associated with ADHD. In addition, in index children with ADHD, associations with comorbid disorders, inattentive and hyperactive-impulsive symptoms were explored. N363S minor allele carriers were more likely to show comorbid conduct disorder (CD). In our study, NR3C1 variants moderately affected ADHD and had a significant effect on comorbid CD. Therefore, NR3C1 as an important gene of the hypothalamic-pituitary-adrenal axis seems to be particularly relevant for the pathophysiology of ADHD combined with comorbid CD. For a deeper understanding, investigations in larger samples of healthy, ADHD and CD individuals are warranted.en_US
dc.description.sponsorshipGerman Research Organization (Deutsche Forschungsgemeinschaft, DFG) European Community (FemNAT-CD, FP7)en_US
dc.language.isoenen_US
dc.publisherELSEVIER IRELANDen_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0165178115307484en_US
dc.rightsCopyright © 2016 Elsevier Ireland Ltd. All rights reserved.
dc.subjectADHDen_US
dc.subjectAssociationen_US
dc.subjectConduct disorderen_US
dc.subjectCortisolen_US
dc.subjectNR3C1en_US
dc.subjectSNPsen_US
dc.subjectGenen_US
dc.subjectHegðunarröskunen_US
dc.subject.meshAttention Deficit Disorder with Hyperactivityen_US
dc.subject.meshConduct Disorderen_US
dc.subject.meshReceptors, Glucocorticoiden_US
dc.subject.meshGenesen_US
dc.titleGlucocorticoid receptor variants in childhood attention-deficit/hyperactivity disorder and comorbid psychiatric disorders.en_US
dc.typeArticleen_US
dc.identifier.eissn1872-7123
dc.contributor.department1 Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, Trier, Germany. Electronic address: schotefrese@uni-trier.de. 2 Department of Neurobehavioral Genetics, Institute of Psychobiology, University of Trier, Trier, Germany. 3 Department of Child and Adolescent Psychiatry and Psychotherapy, Saarland University Hospital, Homburg, Germany. 4 Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, JW Goethe University, Frankfurt am Main, Germany.en_US
dc.identifier.journalPsychiatry Researchen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.source.journaltitlePsychiatry research
dc.source.volume246
dc.source.beginpage275
dc.source.endpage283
dc.source.countryIreland


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