Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury.
Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Björnsson, Einar SIssue Date
2019-10-28
Metadata
Show full item recordCitation
Björnsson ES. Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury. Clin Liver Dis. 2020;24(1):1–10. doi:10.1016/j.cld.2019.08.002Abstract
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. A recent population-based study found a crude incidence of approximately 19 cases per 100,000 a year. Amoxicillin-clavulanate continues to be the most commonly implicated agent in most Western countries, reported to occur in approximately 1 of 2300 users. In patients with drug-induced autoimmune hepatitis, liver tests often do not normalize with cessation of the drugs and require corticosteroids. DILI associated with jaundice can lead to death from liver failure or require liver transplantation in at least 10% of cases.Description
To access publisher's full text version of this article click on the hyperlink belowRights
Copyright © 2019 Elsevier Inc. All rights reserved.ae974a485f413a2113503eed53cd6c53
10.1016/j.cld.2019.08.002
Scopus Count
Collections
Related articles
- Epidemiology and risk factors for idiosyncratic drug-induced liver injury.
- Authors: Björnsson ES
- Issue date: 2014 May
- Hepatotoxicity by Drugs: The Most Common Implicated Agents.
- Authors: Björnsson ES
- Issue date: 2016 Feb 6
- Drug-induced liver injury.
- Authors: Leise MD, Poterucha JJ, Talwalkar JA
- Issue date: 2014 Jan
- Drug-induced liver injury: an overview over the most critical compounds.
- Authors: Björnsson ES
- Issue date: 2015 Mar
- Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland.
- Authors: Björnsson ES, Bergmann OM, Björnsson HK, Kvaran RB, Olafsson S
- Issue date: 2013 Jun