Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury.

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Authors
Björnsson, Einar S
Issue Date
2019-10-28

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Björnsson ES. Epidemiology, Predisposing Factors, and Outcomes of Drug-Induced Liver Injury. Clin Liver Dis. 2020;24(1):1–10. doi:10.1016/j.cld.2019.08.002
Abstract
Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. A recent population-based study found a crude incidence of approximately 19 cases per 100,000 a year. Amoxicillin-clavulanate continues to be the most commonly implicated agent in most Western countries, reported to occur in approximately 1 of 2300 users. In patients with drug-induced autoimmune hepatitis, liver tests often do not normalize with cessation of the drugs and require corticosteroids. DILI associated with jaundice can lead to death from liver failure or require liver transplantation in at least 10% of cases.
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https://www.sciencedirect.com/science/article/abs/pii/S1089326119300522?via%3Dihub
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Copyright © 2019 Elsevier Inc. All rights reserved.
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