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Innovative in vitro method to study ventilator induced lung injury.

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Authors
Joelsson, Jon P
Myszor, Iwona T
Arason, Ari J
Ingthorsson, Saevar
Cherek, Paulina
Windels, Gabriel S
Leosson, Kristjan
Gudmundsson, Gudmundur H
Gudjonsson, Thorarinn
Karason, Sigurbergur
Issue Date
2019-06-05

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Joelsson JP, Myszor IT, Arason AJ, et al. Innovative in vitro method to study ventilator induced lung injury. ALTEX. 2019;36(4):634–642. doi:10.14573/altex.1901182
Abstract
Mechanical ventilation (MV) is a life-saving therapy for critically ill patients, alleviating the work of breathing and supporting adequate gas exchange. However, MV can cause ventilator induced lung injury (VILI) by baro/volu- and atelectrauma, even lead to acute respiratory distress syndrome (ARDS), and substantially augment mortality. There is a need for specific biomarkers and novel research platforms for VILI/ARDS research to study these detrimental disorders and seek ways to avoid or prevent them. Previous in vitro studies on bronchial epithelium, cultured in air-liquid interface (ALI) conditions, have generally utilized static or constant pressure. We have developed a Cyclical Pressure ALI Device (CPAD) that enables cyclical stress on ALI cultured human bronchial cells, with the aim of mimicking the effects of MV. Using CPAD we were able to analyze differentially expressed VILI/ARDS and innate immunity associated genes along with increased expression of associated proteins. CPAD provides an easy and accessible way to analyze functional and phenotypic changes that occur during VILI and may provide a platform for future drug testing.
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https://www.altex.org/index.php/altex/article/view/1245
ae974a485f413a2113503eed53cd6c53
10.14573/altex.1901182
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