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An Isocaloric Nordic Diet Modulates and Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study.

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Authors
Ulven, Stine M
Holven, Kirsten B
Rundblad, Amanda
Myhrstad, Mari C W
Leder, Lena
Dahlman, Ingrid
Mello, Vanessa D de
Schwab, Ursula
Carlberg, Carsten
Pihlajamäki, Jussi
Hermansen, Kjeld
Dragsted, Lars O
Gunnarsdottir, Ingibjörg
Cloetens, Lieselotte
Åkesson, Björn
Rosqvist, Fredrik
Hukkanen, Janne
Herzig, Karl-Heinz
Savolainen, Markku J
Risérus, Ulf
Thorsdottir, Inga
Poutanen, Kaisa S
Arner, Peter
Uusitupa, Matti
Kolehmainen, Marjukka
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Issue Date
2019-12-03

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Ulven SM, Holven KB, Rundblad A, et al. An Isocaloric Nordic Diet Modulates RELA and TNFRSF1A Gene Expression in Peripheral Blood Mononuclear Cells in Individuals with Metabolic Syndrome-A SYSDIET Sub-Study. Nutrients. 2019;11(12):2932. Published 2019 Dec 3. doi:10.3390/nu11122932
Abstract
A healthy dietary pattern is associated with a lower risk of metabolic syndrome (MetS) and reduced inflammation. To explore this at the molecular level, we investigated the effect of a Nordic diet (ND) on changes in the gene expression profiles of inflammatory and lipid-related genes in peripheral blood mononuclear cells (PBMCs) of individuals with MetS. We hypothesized that the intake of an ND compared to a control diet (CD) would alter the expression of inflammatory genes and genes involved in lipid metabolism. The individuals with MetS underwent an 18/24-week randomized intervention to compare a ND with a CD. Eighty-eight participants (66% women) were included in this sub-study of the larger SYSDIET study. Fasting PBMCs were collected before and after the intervention and changes in gene expression levels were measured using TaqMan Array Micro Fluidic Cards. Forty-eight pre-determined inflammatory and lipid related gene transcripts were analyzed. The expression level of the gene tumor necrosis factor (TNF) receptor superfamily member 1A (TNFRSF1A) was down-regulated (p = 0.004), whereas the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) subunit, RELAproto-oncogene, was up-regulated (p = 0.016) in the ND group compared to the CD group. In conclusion, intake of an ND in individuals with the MetS may affect immune function.
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https://www.mdpi.com/2072-6643/11/12/2932
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950764/
ae974a485f413a2113503eed53cd6c53
10.3390/nu11122932
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