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dc.contributor.authorHelgadóttir, Hólmfridur
dc.contributor.authorLund, Sigrún H
dc.contributor.authorGizurarson, Sveinbjörn
dc.contributor.authorMetz, David C
dc.contributor.authorBjörnsson, Einar S
dc.date.accessioned2020-03-31T18:22:11Z
dc.date.available2020-03-31T18:22:11Z
dc.date.issued2020-03
dc.date.submitted2020-03
dc.identifier.citationHelgadóttir H, Lund SH, Gizurarson S, Metz DC, Björnsson ES. Predictors of Gastrin Elevation Following Proton Pump Inhibitor Therapy. J Clin Gastroenterol. 2020;54(3):227–234. doi:10.1097/MCG.0000000000001200en_US
dc.identifier.pmid30994520
dc.identifier.doi10.1097/MCG.0000000000001200
dc.identifier.urihttp://hdl.handle.net/2336/621341
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractGoals: The goal of this study was to elucidate the most important predictors for elevation of gastrin in patients on long-term PPI therapy through analysis of data from 2 published studies in Icelandic patients with erosive GERD. Background: Gastrin elevation is a known but variable consequence of proton pump inhibitor (PPI) therapy. Concerns have been raised about the clinical importance of chronic PPI induced gastrin elevation. Study: This cross-sectional analysis included patients with endoscopically verified erosive esophagitis receiving long-term PPI therapy. PPI exposure in dosage over weight (mg/kg) and dosage over body surface area (mg/m) was compared with fasting gastrin levels in two separate multiple linear regression models. Data was collected on age, gender, weight, H. pylori infection, smoking, PPI duration and type. Results: Overall data from 157 patients (78 females) were analyzed. Median serum gastrin levels were higher in females than males (92 vs. 60 pg/mL; P=0.001). Simple linear regression showed a correlation between serum gastrin levels and gender (P=0.0008) as well as PPI exposure in mg/kg (P=0.0001) and mg/m (P=0.0001). Multiple linear regression analysis showed that PPI exposure, both in mg/kg (β=0.95 [CI=0.4-1.5]; P=0.001) and mg/m (β=0.02 [CI=0.0-0.0]; P=0.0015) along with female gender (β=0.2 [CI=0.0-0.4]; P=0.02) predicted higher gastrin values. Conclusions: Dosage and female gender seem to play an important role in the development of gastrin elevation on PPI therapy. A significant correlation was found between fasting serum gastrin and dosage of PPIs over weight and body surface area.en_US
dc.description.sponsorshipResearch Fund of the National University Hospital of Iceland University of Iceland Research Fund United States Department of Health & Human Services National Institutes of Health (NIH) - USA Icelandic Research Funden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Healthen_US
dc.relation.urlhttps://journals.lww.com/jcge/Abstract/2020/03000/Predictors_of_Gastrin_Elevation_Following_Proton.6.aspxen_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800823/en_US
dc.subjectPrótónupumpuhemlaren_US
dc.subjectMeltingarfærasjúkdómaren_US
dc.subject.meshProton Pump Inhibitorsen_US
dc.subject.meshGastrinsen_US
dc.titlePredictors of Gastrin Elevation Following Proton Pump Inhibitor Therapy.en_US
dc.typeArticleen_US
dc.identifier.eissn1539-2031
dc.contributor.department1Department of Internal Medicine, Division of Gastroenterology, Landspitali-The National University Hospital of Iceland. 2Faculty of Medicine. 3Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavík, Iceland. 4Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.en_US
dc.identifier.journalJournal of clinical gastroenterologyen_US
dc.rights.accessLandspitali Access - LSH-aðganguren_US
dc.departmentcodeGAS12
dc.source.journaltitleJournal of clinical gastroenterology
dc.source.volume54
dc.source.issue3
dc.source.beginpage227
dc.source.endpage234
dc.source.countryUnited States
dc.source.countryUnited States


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