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Association of Genomic Domains in and with Prostate Cancer Risk and Aggressiveness.

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Authors
Patel, Vivek L
Busch, Evan L
Friebel, Tara M
Cronin, Angel
Leslie, Goska
McGuffog, Lesley
Adlard, Julian
Agata, Simona
Agnarsson, Bjarni A
Ahmed, Munaza
Aittomäki, Kristiina
Alducci, Elisa
Andrulis, Irene L
Arason, Adalgeir
Arnold, Norbert
Artioli, Grazia
Arver, Brita
Auber, Bernd
Azzollini, Jacopo
Balmaña, Judith
Barkardottir, Rosa B
Barnes, Daniel R
Barroso, Alicia
Barrowdale, Daniel
Belotti, Muriel
Benitez, Javier
Bertelsen, Brigitte
Blok, Marinus J
Bodrogi, Istvan
Bonadona, Valérie
Bonanni, Bernardo
Bondavalli, Davide
Boonen, Susanne E
Borde, Julika
Borg, Ake
Bradbury, Angela R
Brady, Angela
Brewer, Carole
Brunet, Joan
Buecher, Bruno
Buys, Saundra S
Cabezas-Camarero, Santiago
Caldés, Trinidad
Caliebe, Almuth
Caligo, Maria A
Calvello, Mariarosaria
Campbell, Ian G
Carnevali, Ileana
Carrasco, Estela
Chan, Tsun L
Chu, Annie T W
Chung, Wendy K
Claes, Kathleen B M
Collaborators, Gemo Study
Collaborators, Embrace
Cook, Jackie
Cortesi, Laura
Couch, Fergus J
Daly, Mary B
Damante, Giuseppe
Darder, Esther
Davidson, Rosemarie
de la Hoya, Miguel
Puppa, Lara Della
Dennis, Joe
Díez, Orland
Ding, Yuan Chun
Ditsch, Nina
Domchek, Susan M
Donaldson, Alan
Dworniczak, Bernd
Easton, Douglas F
Eccles, Diana M
Eeles, Rosalind A
Ehrencrona, Hans
Ejlertsen, Bent
Engel, Christoph
Evans, D Gareth
Faivre, Laurence
Faust, Ulrike
Feliubadaló, Lídia
Foretova, Lenka
Fostira, Florentia
Fountzilas, George
Frost, Debra
García-Barberán, Vanesa
Garre, Pilar
Gauthier-Villars, Marion
Géczi, Lajos
Gehrig, Andrea
Gerdes, Anne-Marie
Gesta, Paul
Giannini, Giuseppe
Glendon, Gord
Godwin, Andrew K
Goldgar, David E
Greene, Mark H
Gutierrez-Barrera, Angelica M
Hahnen, Eric
Hamann, Ute
Hauke, Jan
Herold, Natalie
Hogervorst, Frans B L
Honisch, Ellen
Hopper, John L
Hulick, Peter J
Investigators, KConFab
Investigators, Hebon
Izatt, Louise
Jager, Agnes
James, Paul
Janavicius, Ramunas
Jensen, Uffe Birk
Jensen, Thomas Dyrso
Johannsson, Oskar Th
John, Esther M
Joseph, Vijai
Kang, Eunyoung
Kast, Karin
Kiiski, Johanna I
Kim, Sung-Won
Kim, Zisun
Ko, Kwang-Pil
Konstantopoulou, Irene
Kramer, Gero
Krogh, Lotte
Kruse, Torben A
Kwong, Ava
Larsen, Mirjam
Lasset, Christine
Lautrup, Charlotte
Lazaro, Conxi
Lee, Jihyoun
Lee, Jong Won
Lee, Min Hyuk
Lemke, Johannes
Lesueur, Fabienne
Liljegren, Annelie
Lindblom, Annika
Llovet, Patricia
Lopez-Fernández, Adria
Lopez-Perolio, Irene
Lorca, Victor
Loud, Jennifer T
Ma, Edmond S K
Mai, Phuong L
Manoukian, Siranoush
Mari, Veronique
Martin, Lynn
Matricardi, Laura
Mebirouk, Noura
Medici, Veronica
Meijers-Heijboer, Hanne E J
Meindl, Alfons
Mensenkamp, Arjen R
Miller, Clare
Gomes, Denise Molina
Montagna, Marco
Mooij, Thea M
Moserle, Lidia
Mouret-Fourme, Emmanuelle
Mulligan, Anna Marie
Nathanson, Katherine L
Navratilova, Marie
Nevanlinna, Heli
Niederacher, Dieter
Nielsen, Finn C Cilius
Nikitina-Zake, Liene
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I
Ong, Kai-Ren
Osorio, Ana
Ott, Claus-Eric
Palli, Domenico
Park, Sue K
Parsons, Michael T
Pedersen, Inge Sokilde
Peissel, Bernard
Peixoto, Ana
Pérez-Segura, Pedro
Peterlongo, Paolo
Petersen, Annabeth Høgh
Porteous, Mary E
Pujana, Miguel Angel
Radice, Paolo
Ramser, Juliane
Rantala, Johanna
Rashid, Muhammad U
Rhiem, Kerstin
Rizzolo, Piera
Robson, Mark E
Rookus, Matti A
Rossing, Caroline M
Ruddy, Kathryn J
Santos, Catarina
Saule, Claire
Scarpitta, Rosa
Schmutzler, Rita K
Schuster, Hélène
Senter, Leigha
Seynaeve, Caroline M
Shah, Payal D
Sharma, Priyanka
Shin, Vivian Y
Silvestri, Valentina
Simard, Jacques
Singer, Christian F
Skytte, Anne-Bine
Snape, Katie
Solano, Angela R
Soucy, Penny
Southey, Melissa C
Spurdle, Amanda B
Steele, Linda
Steinemann, Doris
Stoppa-Lyonnet, Dominique
Stradella, Agostina
Sunde, Lone
Sutter, Christian
Tan, Yen Y
Teixeira, Manuel R
Teo, Soo Hwang
Thomassen, Mads
Tibiletti, Maria Grazia
Tischkowitz, Marc
Tognazzo, Silvia
Toland, Amanda E
Tommasi, Stefania
Torres, Diana
Toss, Angela
Trainer, Alison H
Tung, Nadine
van Asperen, Christi J
van der Baan, Frederieke H
van der Kolk, Lizet E
van der Luijt, Rob B
van Hest, Liselotte P
Varesco, Liliana
Varon-Mateeva, Raymonda
Viel, Alessandra
Vierstrate, Jeroen
Villa, Roberta
von Wachenfeldt, Anna
Wagner, Philipp
Wang-Gohrke, Shan
Wappenschmidt, Barbara
Weitzel, Jeffrey N
Wieme, Greet
Yadav, Siddhartha
Yannoukakos, Drakoulis
Yoon, Sook-Yee
Zanzottera, Cristina
Zorn, Kristin K
D'Amico, Anthony V
Freedman, Matthew L
Pomerantz, Mark M
Chenevix-Trench, Georgia
Antoniou, Antonis C
Neuhausen, Susan L
Ottini, Laura
Nielsen, Henriette Roed
Rebbeck, Timothy R
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Issue Date
2019-11-13

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Other Titles
Association of Genomic Domains in BRCA1 and BRCA2 With Prostate Cancer Risk and Aggressiveness
Citation
Patel VL, Busch EL, Friebel TM, et al. Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. Cancer Res. 2020;80(3):624–638. doi:10.1158/0008-5472.CAN-19-1840
Abstract
Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.
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To access publisher's full text version of this article click on the hyperlink below
Additional Links
https://cancerres.aacrjournals.org/content/80/3/624.long
https://cancerres.aacrjournals.org/content/canres/80/3/624.full.pdf
Rights
©2019 American Association for Cancer Research.
ae974a485f413a2113503eed53cd6c53
10.1158/0008-5472.CAN-19-1840
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