Transcriptome-wide Association Study of Breast Cancer Risk by Estrogen-Receptor Status
Average rating
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Star rating
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Authors
Feng, HelianGusev, Alexander
Pasaniuc, Bogdan
Wu, Lang
Long, Jirong
Abu-Full, Zomoroda
Aittomäki, Kristiina
Andrulis, Irene L
Anton-Culver, Hoda
Antoniou, Antonis C
Arason, Adalgeir
Arndt, Volker
Aronson, Kristan J
Arun, Banu K
Asseryanis, Ella
Auer, Paul L
Azzollini, Jacopo
Balmaña, Judith
Barkardottir, Rosa B
Barnes, Daniel R
Barrowdale, Daniel
Beckmann, Matthias W
Behrens, Sabine
Benitez, Javier
Bermisheva, Marina
Białkowska, Katarzyna
Blanco, Ana
Blomqvist, Carl
Boeckx, Bram
Bogdanova, Natalia V
Bojesen, Stig E
Bolla, Manjeet K
Bonanni, Bernardo
Borg, Ake
Brauch, Hiltrud
Brenner, Hermann
Briceno, Ignacio
Broeks, Annegien
Brüning, Thomas
Burwinkel, Barbara
Cai, Qiuyin
Caldés, Trinidad
Caligo, Maria A
Campbell, Ian
Canisius, Sander
Campa, Daniele
Carter, Brian D
Carter, Jonathan
Castelao, Jose E
Chang-Claude, Jenny
Chanock, Stephen J
Christiansen, Hans
Chung, Wendy K
Claes, Kathleen B M
Clarke, Christine L
Couch, Fergus J
Cox, Angela
Cross, Simon S
Cybulski, Cezary
Czene, Kamila
Daly, Mary B
de la Hoya, Miguel
De Leeneer, Kim
Dennis, Joe
Devilee, Peter
Diez, Orland
Domchek, Susan M
Dörk, Thilo
Dos-Santos-Silva, Isabel
Dunning, Alison M
Dwek, Miriam
Eccles, Diana M
Ejlertsen, Bent
Ellberg, Carolina
Engel, Christoph
Eriksson, Mikael
Fasching, Peter A
Fletcher, Olivia
Flyger, Henrik
Fostira, Florentia
Friedman, Eitan
Fritschi, Lin
Frost, Debra
Gabrielson, Marike
Ganz, Patricia A
Gapstur, Susan M
Garber, Judy
García-Closas, Montserrat
García-Sáenz, José A
Gaudet, Mia M
Giles, Graham G
Glendon, Gord
Godwin, Andrew K
Goldberg, Mark S
Goldgar, David E
González-Neira, Anna
Greene, Mark H
Gronwald, Jacek
Guénel, Pascal
Haiman, Christopher A
Hall, Per
Hamann, Ute
Hake, Christopher
He, Wei
Heyworth, Jane
Hogervorst, Frans B L
Hollestelle, Antoinette
Hooning, Maartje J
Hoover, Robert N
Hopper, John L
Huang, Guanmengqian
Hulick, Peter J
Humphreys, Keith
Imyanitov, Evgeny N
Isaacs, Claudine
Jakimovska, Milena
Jakubowska, Anna
James, Paul
Janavicius, Ramunas
Jankowitz, Rachel C
John, Esther M
Johnson, Nichola
Joseph, Vijai
Jung, Audrey
Karlan, Beth Y
Khusnutdinova, Elza
Kiiski, Johanna I
Konstantopoulou, Irene
Kristensen, Vessela N
Laitman, Yael
Lambrechts, Diether
Lazaro, Conxi
Leroux, Dominique
Leslie, Goska
Lester, Jenny
Lesueur, Fabienne
Lindor, Noralane
Lindström, Sara
Lo, Wing-Yee
Loud, Jennifer T
Lubiński, Jan
Makalic, Enes
Mannermaa, Arto
Manoochehri, Mehdi
Manoukian, Siranoush
Margolin, Sara
Martens, John W M
Martinez, Maria E
Matricardi, Laura
Maurer, Tabea
Mavroudis, Dimitrios
McGuffog, Lesley
Meindl, Alfons
Menon, Usha
Michailidou, Kyriaki
Kapoor, Pooja M
Miller, Austin
Montagna, Marco
Moreno, Fernando
Moserle, Lidia
Mulligan, Anna M
Muranen, Taru A
Nathanson, Katherine L
Neuhausen, Susan L
Nevanlinna, Heli
Nevelsteen, Ines
Nielsen, Finn C
Nikitina-Zake, Liene
Offit, Kenneth
Olah, Edith
Olopade, Olufunmilayo I
Olsson, Håkan
Osorio, Ana
Papp, Janos
Park-Simon, Tjoung-Won
Parsons, Michael T
Pedersen, Inge S
Peixoto, Ana
Peterlongo, Paolo
Peto, Julian
Pharoah, Paul D P
Phillips, Kelly-Anne
Plaseska-Karanfilska, Dijana
Poppe, Bruce
Pradhan, Nisha
Prajzendanc, Karolina
Presneau, Nadege
Punie, Kevin
Pylkäs, Katri
Radice, Paolo
Rantala, Johanna
Rashid, Muhammad Usman
Rennert, Gad
Risch, Harvey A
Robson, Mark
Romero, Atocha
Saloustros, Emmanouil
Sandler, Dale P
Santos, Catarina
Sawyer, Elinor J
Schmidt, Marjanka K
Schmidt, Daniel F
Schmutzler, Rita K
Schoemaker, Minouk J
Scott, Rodney J
Sharma, Priyanka
Shu, Xiao-Ou
Simard, Jacques
Singer, Christian F
Skytte, Anne-Bine
Soucy, Penny
Southey, Melissa C
Spinelli, John J
Spurdle, Amanda B
Stone, Jennifer
Swerdlow, Anthony J
Tapper, William J
Taylor, Jack A
Teixeira, Manuel R
Terry, Mary Beth
Teulé, Alex
Thomassen, Mads
Thöne, Kathrin
Thull, Darcy L
Tischkowitz, Marc
Toland, Amanda E
Tollenaar, Rob A E M
Torres, Diana
Truong, Thérèse
Tung, Nadine
Vachon, Celine M
van Asperen, Christi J
van den Ouweland, Ans M W
van Rensburg, Elizabeth J
Vega, Ana
Viel, Alessandra
Vieiro-Balo, Paula
Wang, Qin
Wappenschmidt, Barbara
Weinberg, Clarice R
Weitzel, Jeffrey N
Wendt, Camilla
Winqvist, Robert
Yang, Xiaohong R
Yannoukakos, Drakoulis
Ziogas, Argyrios
Milne, Roger L
Easton, Douglas F
Chenevix-Trench, Georgia
Zheng, Wei
Kraft, Peter
Jiang, Xia
Issue Date
2020-03-01
Metadata
Show full item recordAbstract
Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta-analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER-). We further compared associations with ER+ and ER- subtypes, using a case-only TWAS approach. We also conducted multigene conditional analyses in regions with multiple TWAS associations. Two genes, STXBP4 and HIST2H2BA, were specifically associated with ER+ but not with ER- breast cancer. We further identified 30 TWAS-significant genes associated with overall breast cancer risk, including four that were not identified in previous studies. Conditional analyses identified single independent breast-cancer gene in three of six regions harboring multiple TWAS-significant genes. Our study provides new information on breast cancer genetics and biology, particularly about genomic differences between ER+ and ER- breast cancer.Description
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadAdditional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/gepi.22288Collections