Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma.
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Antó, Josep M
Ferreira, Diogenes Seraphim
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CitationMarcon A, Marchetti P, Antó JM, et al. Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma. J Allergy Clin Immunol Pract. 2020;8(3):980–988.e10. doi:10.1016/j.jaip.2019.10.023
AbstractBackground: Inhaled corticosteroids (ICSs) are the mainstay of asthma treatment, but response to medication is variable. Patients with allergic inflammation generally show a better short-term response to ICSs; however, studies on predictors of long-term response are few. Objective: To assess whether allergic sensitization can modify the association between ICS use and lung function decline over 20 years in adult asthma. Methods: We used data from the 3 clinical examinations of the European Community Respiratory Health Survey. We measured ICS use (no use, and use for <1.3, 1.3-8, and >8 years) and FEV1 decline among subjects with asthma over the 2 periods between consecutive examinations. We conducted a cohort study combining data of the 2 periods (906 observations from 745 subjects) to assess whether the association between ICS use and FEV1 decline was modified by allergic sensitization (IgE > 0.35 kU/L for any of house-dust mite, timothy grass, cat, or Cladosporium). Results: FEV1 decline was similar for non-ICS users, as well as ICS users for less than 1.3 years, with and without allergic sensitization. However, among subjects on ICSs for a longer period, sensitization was associated with an attenuated decline (Pinteraction = .006): in the group treated for more than 8 years, FEV1 decline was on average 27 mL/y (95% CIBonferroni-adjusted, 11-42) lower for subjects with sensitization compared with nonsensitized subjects. Conclusions: Our study suggests that biomarkers of atopy can predict a more favorable long-term response to ICSs. Randomized controlled studies are needed to confirm these findings.
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RightsCopyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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- Authors: de Marco R, Marcon A, Jarvis D, Accordini S, Bugiani M, Cazzoletti L, Cerveri I, Corsico A, Gislason D, Gulsvik A, Jõgi R, Martínez-Moratalla J, Pin I, Janson C, ECRHS Therapy Group.
- Issue date: 2007 Mar
- Sensitization to common allergens and its association with allergic disorders at age 4 years: a whole population birth cohort study.
- Authors: Arshad SH, Tariq SM, Matthews S, Hakim E
- Issue date: 2001 Aug
- FEV<sub>1</sub> decline in relation to blood eosinophils and neutrophils in a population-based asthma cohort.
- Authors: Backman H, Lindberg A, Hedman L, Stridsman C, Jansson SA, Sandström T, Lundbäck B, Rönmark E
- Issue date: 2020 Mar
- Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases: S2k Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergy and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA), the Austrian Society for Allergy and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Dermatology (DDG), the German Society of Oto- Rhino-Laryngology, Head and Neck Surgery (DGHNO-KHC), the German Society of Pediatrics and Adolescent Medicine (DGKJ), the Society for Pediatric Pneumology (GPP), the German Respiratory Society (DGP), the German Association of ENT Surgeons (BV-HNO), the Professional Federation of Paediatricians and Youth Doctors (BVKJ), the Federal Association of Pulmonologists (BDP) and the German Dermatologists Association (BVDD).
- Authors: Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J, Kaul S, Schwalfenberg A
- Issue date: 2014
- Specific sensitization to common allergens and pulmonary function in the European Community Respiratory Health Survey.
- Authors: Jaén A, Sunyer J, Basagaña X, Chinn S, Zock JP, Antó JM, Burney P, European Community Respiratory Health Survey.
- Issue date: 2002 Dec