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dc.contributor.authorThorolfsdottir, Eirny
dc.contributor.authorLunde, Åshild
dc.contributor.authorStefansdottir, Vigdis
dc.contributor.authorHjartardottir, Hulda
dc.contributor.authorRut Haraldsdottir, Kristin
dc.date.accessioned2020-05-05T15:23:44Z
dc.date.available2020-05-05T15:23:44Z
dc.date.issued2020-03-21
dc.date.submitted2020-05
dc.identifier.citationThorolfsdottir E, Lunde Å, Stefansdottir V, Hjartardottir H, Rut Haraldsdottir K. Comparing prenatal screening experiences of Icelandic women who received false-positive and true-negative first-trimester combined screening results in Iceland in 2012-2016 [published online ahead of print, 2020 Mar 21]. J Genet Couns. 2020;10.1002/jgc4.1269. doi:10.1002/jgc4.1269en_US
dc.identifier.pmid32198907
dc.identifier.doi10.1002/jgc4.1269
dc.identifier.urihttp://hdl.handle.net/2336/621371
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractFirst-trimester combined screening (FTS) has been offered to all pregnant women in Iceland since 2003. Individuals with high-risk FTS results are offered an invasive test option with a ≤1% risk of fetal loss. This study gives insight into the prenatal screening and diagnosis experiences and preferences of 101 women who underwent FTS in Iceland in the years 2012-2016, comparing the experience of those who received false-positive FTS results to those who received true-negative results. Retrospective patient-reported anxiety levels at the time of receiving FTS results were significantly higher in those who received false-positive results compared to those who received true-negative results. For a subset of these participants, the anxiety lasted through pregnancy, and for a smaller subset, it lasted even longer. Non-invasive prenatal testing (NIPT) is currently not offered in Iceland, aside from the rare exceptional case. Given the extremely low false-positive rates of NIPT, we believe NIPT is worth considering as Iceland's standard first-tier screening method for trisomy 13, 18, and 21. We believe the findings of this study are beneficial not only for Iceland but also for other countries where FTS is the first-tier prenatal screening method or the only offered test. Additionally, only 21% of participants in our study reported that they had heard of NIPT, which emphasizes the need for comprehensive NIPT pretest information to be available prior to its uptake to ensure informed and autonomous decision-making.en_US
dc.description.sponsorshipDepartment of Genetics and Molecular Medicine at Landspitali University Hospitalen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jgc4.1269en_US
dc.rights© 2020 National Society of Genetic Counselors.
dc.subjectanxietyen_US
dc.subjectattitudesen_US
dc.subjectdown syndromeen_US
dc.subjectfalse-positive resultsen_US
dc.subjectfirst-trimester combined Screening (FTS)en_US
dc.subjectgenetic counselingen_US
dc.subjectinvasive prenatal testing (IPT)en_US
dc.subjectnon-invasive prenatal testing (NIPT)en_US
dc.subjectprenatal diagnosisen_US
dc.subjecttrisomiesen_US
dc.subjectFósturgreiningen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.titleComparing prenatal screening experiences of Icelandic women who received false-positive and true-negative first-trimester combined screening results in Iceland in 2012-2016.en_US
dc.typeArticleen_US
dc.identifier.eissn1573-3599
dc.contributor.department1Department of Genetics and Molecular Medicine, Landspitali University Hospital, Reykjavik, Iceland. 2Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. 3Prenatal Diagnostic Unit, Women's and Children's Services, Landspitali University Hospital, Reykjavik, Iceland.en_US
dc.identifier.journalJournal of genetic counselingen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeNAF12
dc.departmentcodeOAG12
dc.departmentcodeMIW12
dc.source.journaltitleJournal of genetic counseling
dc.source.countryUnited States


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