Abstinence from alcohol and alcohol rehabilitation therapy in alcoholic liver disease: a population-based study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsBjörnsson, Einar S
Agustsson, Arnar S
Lund, Sigrun H
MetadataShow full item record
CitationBjörnsson ES, Hauksson K, Sigurdardottir R, et al. Abstinence from alcohol and alcohol rehabilitation therapy in alcoholic liver disease: a population-based study [published online ahead of print, 2020 Apr 1]. Scand J Gastroenterol. 2020;1‐7. doi:10.1080/00365521.2020.1743751
AbstractObjective: Abstinence from alcohol is recommended in patients diagnosed with alcoholic hepatitis (AH) and alcoholic cirrhosis (AC). We aimed to determine the impact of alcohol abstinence on prognosis of patients with AC and AH.Methods: All incident AC and AH patients in Iceland 2001-2016 were identified. Cirrhosis was confirmed clinically, biochemically, with imaging and histologically. Abstinence, alcohol rehabilitation and survival were analyzed.Results: Overall, 169 patients with AC and/or AH were identified. Eleven died during index hospitalization, leaving 158 patients for final analysis, median (IQR) age 56 years (48-65), 72% males. Over all 61 patients (39%) had AC, 40 (25%) AH and 57 (36%) features of both. Thirty-nine percent of patients remained abstinent during follow-up and 63% underwent alcohol rehabilitation. Moderate to severe ascites at diagnosis (odds ratio (OR): 3.05, 95% confidence interval (CI): 1.37-7.02) and lack of alcoholic rehabilitation (OR: 5.28, 95% CI: 2.24- 14.11) were independent predictors of abstinence. Abstinence at one year of follow-up was not related to increased survival. Patients surviving one year, abstinence during follow-up was related to increased survival for both groups.Conclusion: Abstinence from alcohol following AC/AH diagnosis was achieved in 39% of patients. Abstinence was not related to increased survival for alcoholic liver disease patients at one-year, which might partly indicate that this might be a marker that some patients were 'too sick to drink'. AC and AH patients who survived one year and remained abstinent had a favorable long-term prognosis.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
- Meta-analysis of patient survival and rate of alcohol relapse in liver-transplanted patients for acute alcoholic hepatitis.
- Authors: Al-Saeedi M, Barout MH, Probst P, Khajeh E, Weiss KH, Diener MK, Mehrabi A
- Issue date: 2018 Nov
- Outcomes of Early Liver Transplantation for Patients With Severe Alcoholic Hepatitis.
- Authors: Lee BP, Mehta N, Platt L, Gurakar A, Rice JP, Lucey MR, Im GY, Therapondos G, Han H, Victor DW, Fix OK, Dinges L, Dronamraju D, Hsu C, Voigt MD, Rinella ME, Maddur H, Eswaran S, Hause J, Foley D, Ghobrial RM, Dodge JL, Li Z, Terrault NA
- Issue date: 2018 Aug
- Alcohol abstinence in patients surviving an episode of alcoholic hepatitis: Prediction and impact on long-term survival.
- Authors: Altamirano J, López-Pelayo H, Michelena J, Jones PD, Ortega L, Ginès P, Caballería J, Gual A, Bataller R, Lligoña A
- Issue date: 2017 Dec
- Effect of hepatitis C virus infection and abstinence from alcohol on survival in patients with alcoholic cirrhosis.
- Authors: Serra MA, Escudero A, Rodríguez F, del Olmo JA, Rodrigo JM
- Issue date: 2003 Feb
- Three-year Results of a Pilot Program in Early Liver Transplantation for Severe Alcoholic Hepatitis.
- Authors: Lee BP, Chen PH, Haugen C, Hernaez R, Gurakar A, Philosophe B, Dagher N, Moore SA, Li Z, Cameron AM
- Issue date: 2017 Jan