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dc.contributor.authorGrimshaw, Kate E C
dc.contributor.authorRoberts, Graham
dc.contributor.authorSelby, Anna
dc.contributor.authorReich, Andreas
dc.contributor.authorButiene, Indra
dc.contributor.authorClausen, Michael
dc.contributor.authorDubakiene, Ruta
dc.contributor.authorFiandor, Ana
dc.contributor.authorFiocchi, Alessandro
dc.contributor.authorGrabenhenrich, Linus B
dc.contributor.authorLarco, Jose Ignacio
dc.contributor.authorKowalski, Marek L
dc.contributor.authorRudzeviciene, Odilija
dc.contributor.authorPapadopoulos, Nikolaos G
dc.contributor.authorRosenfeld, Leonard
dc.contributor.authorSigurdardottir, Sigurveig Th
dc.contributor.authorSprikkelman, Aline B
dc.contributor.authorSchoemaker, Ana A
dc.contributor.authorXepapadaki, Paraskevi
dc.contributor.authorMills, E N Clare
dc.contributor.authorKeil, Thomas
dc.contributor.authorBeyer, Kirsten
dc.date.accessioned2020-05-12T10:05:55Z
dc.date.available2020-05-12T10:05:55Z
dc.date.issued2019-12-14
dc.date.submitted2020-05
dc.identifier.citationGrimshaw KEC, Roberts G, Selby A, et al. Risk Factors for Hen's Egg Allergy in Europe: EuroPrevall Birth Cohort. J Allergy Clin Immunol Pract. 2020;8(4):1341‐1348.e5. doi:10.1016/j.jaip.2019.11.040en_US
dc.identifier.pmid31846795
dc.identifier.doi10.1016/j.jaip.2019.11.040
dc.identifier.urihttp://hdl.handle.net/2336/621387
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractBackground: Hen's egg is one of the commonest causes of food allergy, but there are little data on its risk factors. Objective: To assess the risk factors, particularly eczema, for hen's egg allergy in the EuroPrevall birth cohort. Methods: In the pan-European EuroPrevall birth cohort, questionnaires were undertaken at 12 and 24 months or when parents reported symptoms. Children with suspected egg allergy were invited for skin prick testing, specific IgE assessment, and double-blind, placebo-controlled food challenge (DBPCFC) as indicated. Each egg allergy case (positive DBPCFC or egg-induced anaphylaxis) was allocated up to 2 age- and country-matched controls. Results: A total of 12,049 infants were recruited into the EuroPrevall birth cohort, and 9,336 (77.5%) were followed until 2 years. A total of 86 infants had egg allergy (84 by DBPCFC) and were matched with 140 controls. Independently associated with egg allergy were past/current eczema (adjusted odds ratio, 9.21; 95% CI, 2.65-32.04), Scoring Atopic Dermatitis (1.54 per 5 units; 1.28-1.86), antibiotics in the first week of life (6.17; 1.42-26.89), and current rhinitis (3.02; 1.04-8.78). Increasing eczema severity was associated with an increasing likelihood of egg allergy. Eczema was reported to have started 3.6 (SE, 0.5) months before egg allergy. Age of introduction of egg into the diet was not associated with egg allergy. Conclusions: Similar to peanut allergy, eczema was strongly associated with egg allergy development and the association increased with increasing eczema severity. The age of introduction of dietary egg was not a risk factor. The potential role of antibiotics in early life as a risk factor for egg allergy needs further examination.en_US
dc.description.sponsorshipEuropean Commission Joint Research Centre Landspitali University Hospital Science Fund GlaxoSmithKline UK Food Standards Agency MSD Nutricia Advanced Medical Nutrition Netherlands AstraZeneca TEVA Netherlands GlaxoSmithKline Allegria (the Italian Research Foundation for Childhood Allergy and Asthma)en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S2213219819310293?via%3Dihuben_US
dc.relation.urlhttps://search.proquest.com/publication/2031058en_US
dc.rightsCopyright © 2019. Published by Elsevier Inc.
dc.subjectEczemaen_US
dc.subjectFood allergyen_US
dc.subjectHen's eggen_US
dc.subjectInfantsen_US
dc.subjectPreventionen_US
dc.subjectRisk factorsen_US
dc.subject.meshFood Hypersensitivityen_US
dc.subject.meshEggsen_US
dc.titleRisk Factors for Hen's Egg Allergy in Europe: EuroPrevall Birth Cohort.en_US
dc.typeArticleen_US
dc.identifier.eissn2213-2201
dc.contributor.department1Experimental Sciences & Human Development in Health Academic Units, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; Department of Dietetics, Salford Royal Foundation Trust, Salford, United Kingdom. 2Experimental Sciences & Human Development in Health Academic Units, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Hospital, Southampton, United Kingdom. Electronic address: g.c.roberts@soton.ac.uk. 3Experimental Sciences & Human Development in Health Academic Units, Faculty of Medicine, University of Southampton, Southampton, United Kingdom. 4German Rheumatism Research Center, Epidemiology Unit, Berlin, Germany. 5Faculty of Health Sciences, Klaipeda University, Klaipeda, Lithuania. 6Children's Hospital, Landspitali University Hospital, Reykjavik, Iceland. 7Clinic of Children's Diseases, Faculty of Medicine, Vilnius University Faculty of Medicine, Vilnius, Lithuania. 8Department of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain. 9Division of Allergy, Pediatric Hospital Bambino, Rome, Italy. 10Department of Dermatology, Venerology and Allergology, Charité-Universitätsmedizin Berlin, Berlin, Germany; Department for Infectious Disease Epidemiology, Robert Koch-Institute, Berlin, Germany. 11Department of Immunology and Allergy, Medical University of Lodz, Lodz, Poland. 12Allergy Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece; Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom. 13Department of Pediatrics, Division of Pneumology and Immunology with Intensive Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany. 14Department of Immunology, Landspitali University Hospital, Reykjavik, Iceland. 15Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands; Department of Paediatric Pulmonology and Paediatric Allergology, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. 16Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands. 17Allergy Unit, 2nd Pediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece. 18Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Manchester Institute of Biotechnology, University of Manchester, Manchester, United Kingdom. 19Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany; Institute for Health Resort Medicine and Health Promotion, Bavarian Health and Food Safety Authority, Bad Kissingen, Germany.en_US
dc.identifier.journalThe journal of allergy and clinical immunology. In practiceen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeAAI12
dc.departmentcodePED12
dc.source.journaltitleThe journal of allergy and clinical immunology. In practice
dc.source.volume8
dc.source.issue4
dc.source.beginpage1341
dc.source.endpage1348.e5
dc.source.countryUnited States


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