Changes in the left temporal microstate are a sign of cognitive decline in patients with Alzheimer's disease.
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Authors
Musaeus, Christian SEngedal, Knut
Høgh, Peter
Jelic, Vesna
Khanna, Arjun R
Kjaer, Troels Wesenberg
Mørup, Morten
Naik, Mala
Oeksengaard, Anne-Rita
Santarnecchi, Emiliano
Snaedal, Jon
Wahlund, Lars-Olof
Waldemar, Gunhild
Andersen, Birgitte B
Issue Date
2020-04-27
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Musaeus CS, Engedal K, Høgh P, et al. Changes in the left temporal microstate are a sign of cognitive decline in patients with Alzheimer's disease [published online ahead of print, 2020 Apr 27]. Brain Behav. 2020;e01630. doi:10.1002/brb3.1630Abstract
Introduction: Large-scale brain networks are disrupted in the early stages of Alzheimer's disease (AD). Electroencephalography microstate analysis, a promising method for studying brain networks, parses EEG signals into topographies representing discrete, sequential network activations. Prior studies indicate that patients with AD show a pattern of global microstate disorganization. We investigated whether any specific microstate changes could be found in patients with AD and mild cognitive impairment (MCI) compared to healthy controls (HC). Materials and methods: Standard EEGs were obtained from 135 HC, 117 patients with MCI, and 117 patients with AD from six Nordic memory clinics. We parsed the data into four archetypal microstates. Results: There was significantly increased duration, occurrence, and coverage of microstate A in patients with AD and MCI compared to HC. When looking at microstates in specific frequency bands, we found that microstate A was affected in delta (1-4 Hz), theta (4-8 Hz), and beta (13-30 Hz), while microstate D was affected only in the delta and theta bands. Microstate features were able to separate HC from AD with an accuracy of 69.8% and HC from MCI with an accuracy of 58.7%. Conclusions: Further studies are needed to evaluate whether microstates represent a valuable disease classifier. Overall, patients with AD and MCI, as compared to HC, show specific microstate alterations, which are limited to specific frequency bands. These alterations suggest disruption of large-scale cortical networks in AD and MCI, which may be limited to specific frequency bands.Description
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https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.1630Rights
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals, LLC.ae974a485f413a2113503eed53cd6c53
10.1002/brb3.1630
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