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dc.contributor.authorLaasonen, Leena
dc.contributor.authorLindqvist, Ulla
dc.contributor.authorIversen, Lars
dc.contributor.authorEjstrup, Leif
dc.contributor.authorJonmundsson, Thorarinn
dc.contributor.authorStåhle, Mona
dc.contributor.authorGudbjornsson, Bjorn
dc.date.accessioned2020-06-18T14:28:01Z
dc.date.available2020-06-18T14:28:01Z
dc.date.issued2020-04-27
dc.date.submitted2020-06
dc.identifier.citationLaasonen L, Lindqvist U, Iversen L, et al. Radiographic scoring systems for psoriatic arthritis are insufficient for psoriatic arthritis mutilans: results from the Nordic PAM Study. Acta Radiol Open. 2020;9(4):2058460120920797. Published 2020 Apr 27. doi:10.1177/2058460120920797en_US
dc.identifier.issn2058-4601
dc.identifier.pmid32426163
dc.identifier.doi10.1177/2058460120920797
dc.identifier.urihttp://hdl.handle.net/2336/621447
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractBackground: Psoriatic arthritis mutilans (PAM) is the most severe phenotype of psoriatic arthritis (PsA). Purpose: To describe the radiological features in PAM and explore whether existing scoring systems for radiological damage in psoriatic arthritis are applicable for PAM. Material and methods: Radiographs were scored according to the modified Sharp-van der Heijde (mSvdH) and the Psoriatic Arthritis Ratingen Score (PARS) systems for PsA. Results: At inclusion, 55 PAM patients (49% women, mean age 58 ± 12 years) had conventional radiographs of both hands and feet. A total of 869 PAM joints were detected and 193 joints with ankylosis. The mean total mSvdH score was 213.7 ± 137.8 (41% of maximum) with a higher score for hands than for feet: 136.6 ± 90.1 vs. 79.1 ± 60.9. However, the total score was relatively higher in the feet than in the hands when compared to the highest possible scoring (47% vs. 38% of max). The mean total PARS score was 126.3 ± 79.6 (35% of max). Scoring for joint destruction was higher than for proliferation (22% vs. 11% of max). Strong correlation was found between mSvdH and PARS (r2 = 0.913). A significant correlation was found between scoring and duration of arthritis and the Health Assessment Questionnaire. History of smoking, BMI, and gender did not influence the scoring values. Conclusions: The two scoring systems studied may not be ideal to indicate progression of PAM in advanced disease since they reach ceiling effects rather early. Therefore, reporting early signs suggestive of PAM, e.g. signs of pencil-in-cup deformities or osteolysis, is crucial. This would reveal the presence of PAM and might lead to improved treatment in order to minimize joint damage. Keywords: Psoriatic arthritis; mutilans; psoriasis; radiology; scoring systems.en_US
dc.description.sponsorshipNORDPSOen_US
dc.language.isoenen_US
dc.publisherSAGE Publicationsen_US
dc.relation.urlhttps://journals.sagepub.com/doi/10.1177/2058460120920797en_US
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218277/en_US
dc.rights© The Foundation Acta Radiologica 2020.
dc.subjectPsoriatic arthritisen_US
dc.subjectmutilansen_US
dc.subjectpsoriasisen_US
dc.subjectradiologyen_US
dc.subjectscoring systemsen_US
dc.subjectGigtarsjúkdómaren_US
dc.subjectSóríasisen_US
dc.subjectMyndgreining (læknisfræði)en_US
dc.subject.meshArthritis, Psoriaticen_US
dc.subject.meshRadiologyen_US
dc.titleRadiographic scoring systems for psoriatic arthritis are insufficient for psoriatic arthritis mutilans: results from the Nordic PAM Study.en_US
dc.typeArticleen_US
dc.contributor.department1Helsinki Medical Imaging Center, Helsinki University Central Hospital, Helsinki, Finland. 2Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden. 3Department of Dermatology, Aarhus University Hospital, Aarhus, Denmark. 4Department of Rheumatology, Odense University Hospital, Odense, Denmark. 5Centre for Rheumatology Research, University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 6Dermatology Division, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.en_US
dc.identifier.journalActa radiologica openen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeRHE12
dc.source.journaltitleActa radiologica open
dc.source.volume9
dc.source.issue4
dc.source.beginpage2058460120920797
dc.source.endpage
refterms.dateFOA2020-06-18T14:28:01Z
dc.source.countryEngland


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