Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment.
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AuthorsO'Connell, Kevin S
Smeland, Olav B
Fan, Chun C
Askeland, Ragna B
Knudsen, Gun Peggy S
Steen, Nils Eiel
Walters, G Bragi
Haraldsdóttir, Gyða S
Guðmundsson, Ólafur Ó
Dale, Anders M
Andreassen, Ole A
MetadataShow full item record
CitationO'Connell KS, Shadrin A, Smeland OB, et al. Identification of Genetic Loci Shared Between Attention-Deficit/Hyperactivity Disorder, Intelligence, and Educational Attainment. Biol Psychiatry. 2020;87(12):1052-1062. doi:10.1016/j.biopsych.2019.11.015
AbstractBackground: Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder that is consistently associated with lower levels of educational attainment. A recent large genome-wide association study identified common gene variants associated with ADHD, but most of the genetic architecture remains unknown. Methods: We analyzed independent genome-wide association study summary statistics for ADHD (19,099 cases and 34,194 controls), educational attainment (N = 842,499), and general intelligence (N = 269,867) using a conditional/conjunctional false discovery rate (FDR) statistical framework that increases power of discovery by conditioning the FDR on overlapping associations. The genetic variants identified were characterized in terms of function, expression, and biological processes. Results: We identified 58 linkage disequilibrium-independent ADHD-associated loci (conditional FDR < 0.01), of which 30 were shared between ADHD and educational attainment or general intelligence (conjunctional FDR < 0.01) and 46 were novel risk loci for ADHD. Conclusions: These results expand on previous genetic and epidemiological studies and support the hypothesis of a shared genetic basis between these phenotypes. Although the clinical utility of the identified loci remains to be determined, they can be used as resources to guide future studies aiming to disentangle the complex etiologies of ADHD, educational attainment, and general intelligence. Keywords: ADHD; Cognition; Genetic overlap; Mental health; Pleiotropy; Psychiatric disorder.
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RightsCopyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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