Cigarette Smoking Is Associated With Lower Quadriceps Cross-sectional Area and Attenuation in Older Adults.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsMarques, Elisa A
Frank-Wilson, Andrew W
Lang, Thomas F
Jonsson, Palmi V
Harris, Tamara B
MetadataShow full item record
CitationMarques EA, Elbejjani M, Frank-Wilson AW, et al. Cigarette Smoking Is Associated With Lower Quadriceps Cross-sectional Area and Attenuation in Older Adults. Nicotine Tob Res. 2020;22(6):935-941. doi:10.1093/ntr/ntz081
AbstractIntroduction: In addition to well-established links with cardiovascular and respiratory diseases, cigarette smoking may affect skeletal muscle; however, associations with quadriceps atrophy, density, and function are unknown. This study explored the associations of current and former smoking with quadriceps muscle area and attenuation as well as muscle force (assessed as knee extension peak torque) and rate of torque development-a measure of muscle power in older adults. Methods: Data from 4469 older adults, aged 66-95 years at baseline in the Age, Gene/Environment Susceptibility-Reykjavik Study with measurements of thigh computed tomography, isometric knee extension testing, self-reported smoking history, and potential covariates were analyzed. Results: Sex differences were observed in these data; therefore, our final analyses are stratified by sex. In men, both former smokers and current smokers had lower muscle area (with β= -0.10, 95% confidence interval [CI] = -0.17 to -0.03 and β = -0.19, 95% CI = -0.33 to -0.05, respectively) and lower muscle attenuation (ie, higher fat infiltration, β = -0.08, 95% CI = -0.16 to -0.01 and β = -0.17, 95% CI = -0.34 to -0.01, respectively) when compared with never smokers. Smoking status was not associated with male peak torque or rate of torque development. In women, current smoking was associated with lower muscle attenuation (β = -0.24, 95% CI = -0.34 to -0.13) compared to never smoking. Among female smokers (current and former), muscle attenuation and peak torque were lower with increasing pack-years. Conclusions: Results suggest that cigarette smoking is related to multiple muscle properties at older age and that these relationships may be different among men and women. Implications: This article presents novel data, as it examined for the first time the relationship between smoking and computed tomography-derived quadriceps muscle size (cross-sectional area) and attenuation. This study suggests that current cigarette smoking is related to higher muscle fat infiltration, which may have significant health implications for the older population, because of its known association with poor physical function, falls, and hip fractures.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
Rights© The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: email@example.com.
- Associations of Quadriceps Torque Properties with Muscle Size, Attenuation, and Intramuscular Adipose Tissue in Older Adults.
- Authors: Frank-Wilson AW, Chalhoub D, Figueiredo P, Jónsson PV, Siggeirsdóttir K, Sigurdsson S, Eiriksdottir G, Guðnason V, Launer L, Harris TB, AGES-Reykjavik Study.
- Issue date: 2018 Jun 14
- Cigarette smoking and hip volumetric bone mineral density and cortical volume loss in older adults: The AGES-Reykjavik study.
- Authors: Marques EA, Elbejjani M, Gudnason V, Sigurdsson G, Lang T, Sigurdsson S, Aspelund T, Siggeirsdottir K, Launer L, Eiriksdottir G, Harris TB
- Issue date: 2018 Mar
- Association of smoking with abdominal adipose deposition and muscle composition in Coronary Artery Risk Development in Young Adults (CARDIA) participants at mid-life: A population-based cohort study.
- Authors: Terry JG, Hartley KG, Steffen LM, Nair S, Alman AC, Wellons MF, Jacobs DR Jr, Tindle HA, Carr JJ
- Issue date: 2020 Jul
- Skeletal muscle properties and fatigue resistance in relation to smoking history.
- Authors: Wüst RC, Morse CI, de Haan A, Rittweger J, Jones DA, Degens H
- Issue date: 2008 Sep
- Sex- and age-related differences in mid-thigh composition and muscle quality determined by computed tomography in middle-aged and elderly Japanese.
- Authors: Kasai T, Ishiguro N, Matsui Y, Harada A, Takemura M, Yuki A, Kato Y, Otsuka R, Ando F, Shimokata H
- Issue date: 2015 Jun