GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsEriksen, Bjørn O
van der Giet, Markus
Indridasson, Olafur S
Inker, Lesley A
Jenssen, Trond G
Levey, Andrew S
Solbu, Marit D
MetadataShow full item record
CitationEriksen BO, Palsson R, Ebert N, et al. GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts. J Am Soc Nephrol. 2020;31(7):1602-1615. doi:10.1681/ASN.2020020151
AbstractBackground: Population mean GFR is lower in older age, but it is unknown whether healthy aging is associated with preserved rather than lower GFR in some individuals. Methods: We investigated the cross-sectional association between measured GFR, age, and health in persons aged 50-97 years in the general population through a meta-analysis of iohexol clearance measurements in three large European population-based cohorts. We defined a healthy person as having no major chronic disease or risk factors for CKD and all others as unhealthy. We used a generalized additive model to study GFR distribution by age according to health status. Results: There were 935 (22%) GFR measurements in persons who were healthy and 3274 (78%) in persons who were unhealthy. The mean GFR was lower in older age by -0.72 ml/min per 1.73 m2 per year (95% confidence interval [95% CI], -0.96 to -0.48) for men who were healthy versus -1.03 ml/min per 1.73 m2 per year (95% CI, -1.25 to -0.80) for men who were unhealthy, and by -0.92 ml/min per 1.73 m2 per year (95% CI, -1.14 to -0.70) for women who were healthy versus -1.22 ml/min per 1.73 m2 per year (95% CI, -1.43 to -1.02) for women who were unhealthy. For healthy and unhealthy people of both sexes, both the 97.5th and 2.5th GFR percentiles exhibited a negative linear association with age. Conclusions: Healthy aging is associated with a higher mean GFR compared with unhealthy aging. However, both the mean and 97.5 percentiles of the GFR distribution are lower in older persons who are healthy than in middle-aged persons who are healthy. This suggests that healthy aging is not associated with preserved GFR in old age. Keywords: epidemiology and outcomes; geriatric nephrology; glomerular filtration rate; glomerular hyperfiltration; renal dysfunction; renal function decline.
DescriptionTo access publisher's full text version of this article click on the hyperlink below
RightsCopyright © 2020 by the American Society of Nephrology.
- Association of TNF Receptor 2 and CRP with GFR Decline in the General Nondiabetic Population.
- Authors: Schei J, Stefansson VT, Eriksen BO, Jenssen TG, Solbu MD, Wilsgaard T, Melsom T
- Issue date: 2017 Apr 3
- Physical exercise, fasting glucose, and renal hyperfiltration in the general population: the Renal Iohexol Clearance Survey in Tromsø 6 (RENIS-T6).
- Authors: Melsom T, Mathisen UD, Eilertsen BA, Ingebretsen OC, Jenssen T, Njølstad I, Solbu MD, Toft I, Eriksen BO
- Issue date: 2012 Nov
- Effects of Race and Sex on Measured GFR: The Multi-Ethnic Study of Atherosclerosis.
- Authors: Inker LA, Shafi T, Okparavero A, Tighiouart H, Eckfeldt JH, Katz R, Johnson WC, Dermond N, Tariq Z, Benayache I, Post WS, Coresh J, Levey AS, Shlipak MG
- Issue date: 2016 Nov
- High Ambulatory Arterial Stiffness Index Is an Independent Risk Factor for Rapid Age-Related Glomerular Filtration Rate Decline in the General Middle-Aged Population.
- Authors: Eriksen BO, Stefansson VTN, Jenssen TG, Mathisen UD, Schei J, Solbu MD, Wilsgaard T, Melsom T
- Issue date: 2017 Apr
- Comparability of Plasma Iohexol Clearance Across Population-Based Cohorts.
- Authors: Eriksen BO, Schaeffner E, Melsom T, Ebert N, van der Giet M, Gudnason V, Indridasson OS, Karger AB, Levey AS, Schuchardt M, Sørensen LK, Palsson R
- Issue date: 2020 Jul