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dc.contributor.authorEmilsson, Össur Ingi
dc.contributor.authorSundbom, Fredrik
dc.contributor.authorLjunggren, Mirjam
dc.contributor.authorBenediktsdottir, Bryndis
dc.contributor.authorGarcia-Aymerich, Judith
dc.contributor.authorBui, Dinh Son
dc.contributor.authorJarvis, Deborah
dc.contributor.authorOlin, Anna-Carin
dc.contributor.authorFranklin, Karl A
dc.contributor.authorDemoly, Pascal
dc.contributor.authorLindberg, Eva
dc.contributor.authorJanson, Christer
dc.contributor.authorAspelund, Thor
dc.contributor.authorGislason, Thorarinn
dc.date.accessioned2020-09-01T13:47:08Z
dc.date.available2020-09-01T13:47:08Z
dc.date.issued2020-07-06
dc.date.submitted2020-08
dc.identifier.citationEmilsson ÖI, Sundbom F, Ljunggren M, et al. Association between lung function decline and obstructive sleep apnoea: the ALEC study [published online ahead of print, 2020 Jul 6]. Sleep Breath. 2020;10.1007/s11325-020-02086-1. doi:10.1007/s11325-020-02086-1en_US
dc.identifier.pmid32632893
dc.identifier.doi10.1007/s11325-020-02086-1
dc.identifier.urihttp://hdl.handle.net/2336/621501
dc.descriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Downloaden_US
dc.description.abstractPurpose: To study changes in lung function among individuals with a risk of obstructive sleep apnoea (OSA), and if asthma affected this relationship. Methods: We used data from the European Community Respiratory Health Survey II and III, a multicentre general population study. Participants answered questionnaires and performed spirometry at baseline and 10-year follow-up (n = 4,329 attended both visits). Subjects with high risk for OSA were identified from the multivariable apnoea prediction (MAP) index, calculated from BMI, age, gender, and OSA symptoms at follow-up. Asthma was defined as having doctor's diagnosed asthma at follow-up. Primary outcomes were changes in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from baseline to follow-up. Results: Among 5108 participants at follow-up, 991 (19%) had a high risk of OSA based on the MAP index. Participants with high OSA risk more often had wheeze, cough, chest tightness, and breathlessness at follow-up than those with low OSA risk. Lung function declined more rapidly in subjects with high OSA risk (low vs high OSA risk [mean ± SD]: FEV1 = - 41.3 ± 24.3 ml/year vs - 50.8 ± 30.1 ml/year; FVC = - 30.5 ± 31.2 ml/year vs - 45.2 ± 36.3 ml/year). Lung function decline was primarily associated with higher BMI and OSA symptoms. OSA symptoms had a stronger association with lung function decline among asthmatics, compared to non-asthmatics. Conclusion: In the general population, a high probability of obstructive sleep apnoea was related to faster lung function decline in the previous decade. This was driven by a higher BMI and more OSA symptoms among these subjects. The association between OSA symptoms and lung function decline was stronger among asthmatics. Keywords: Asthma; Lung function; Lung function decline; Sleep apnoea.en_US
dc.description.sponsorshipUppsala University European Union (EU)en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.urlhttps://link.springer.com/article/10.1007/s11325-020-02086-1en_US
dc.subjectAsthmaen_US
dc.subjectLung functionen_US
dc.subjectLung function declineen_US
dc.subjectSleep apnoeaen_US
dc.subject.meshSleep Apnea, Obstructiveen_US
dc.subject.meshAsthmaen_US
dc.titleAssociation between lung function decline and obstructive sleep apnoea: the ALEC study.en_US
dc.typeArticleen_US
dc.identifier.eissn1522-1709
dc.contributor.department1Department of Respiratory, Allergy and Sleep Research, Akademiska Sjukhuset, Uppsala University, 751 85, Uppsala, Sweden. ossur.emilsson@medsci.uu.se. 2Department of Respiratory Medicine and Allergology, Akademiska Sjukhuset, Uppsala, Sweden. ossur.emilsson@medsci.uu.se. 3Department of Respiratory, Allergy and Sleep Research, Akademiska Sjukhuset, Uppsala University, 751 85, Uppsala, Sweden. 4Department of Respiratory Medicine and Allergology, Akademiska Sjukhuset, Uppsala, Sweden. 5Department of Sleep Medicine, Landspitali, Reykjavik, Iceland. 6Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 7ISGlobal, Barcelona, Spain. 8Universitat Pompeu Fabra (UPF), Barcelona, Spain. 9CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. 10Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Australia. 11National Heart and Lung Institute, Imperial College London, London, UK. 12Unit of Occupational and Environmental Medicine, University of Gothenburg, Gothenburg, Sweden. 13Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden. 14Department of Pulmonology, Division of Allergy, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France. 15Inserm, Sorbonne Université, Equipe EPAR - IPLESP, Paris, France. 16Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.en_US
dc.identifier.journalSleep & breathing = Schlaf & Atmungen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodePAD12
dc.source.journaltitleSleep & breathing = Schlaf & Atmung
refterms.dateFOA2020-09-01T13:47:08Z
dc.source.countryGermany


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