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dc.contributor.authorPetrova, Teodora
dc.contributor.authorOrellana, Camila
dc.contributor.authorJelic, Vesna
dc.contributor.authorOeksengaard, Anne-Rita
dc.contributor.authorSnaedal, Jon
dc.contributor.authorHøgh, Peter
dc.contributor.authorAndersen, Birgitte Bo
dc.contributor.authorNaik, Mala
dc.contributor.authorEngedal, Knut
dc.contributor.authorWahlund, Lars-Olof
dc.contributor.authorFerreira, Daniel
dc.date.accessioned2020-09-04T13:35:10Z
dc.date.available2020-09-04T13:35:10Z
dc.date.issued2020-05-17
dc.date.submitted2020-09
dc.identifier.citationPetrova T, Orellana C, Jelic V, et al. Cholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases. Psychiatry Res Neuroimaging. 2020;302:111099. doi:10.1016/j.pscychresns.2020.111099en_US
dc.identifier.pmid32505903
dc.identifier.doi10.1016/j.pscychresns.2020.111099
dc.identifier.urihttp://hdl.handle.net/2336/621510
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractCholinergic dysfunction is central in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The electroencephalography-based acetylcholine index (EEG-Ach index) has been proposed as a biomarker of cholinergic dysfunction. However, it is unclear how the EEG-Ach index relates to amyloid-beta pathology and neurodegeneration. We investigated the association between the EEG-Ach index and cerebrospinal fluid (CSF) amyloid-beta, CSF total tau, cortical thickness, and hippocampal volume from magnetic resonance imaging (MRI), and cognition. A total of 127 patients with different neurodegenerative diseases were studied. The EEG-Ach index was calculated from quantitative EEG using statistical pattern recognition. The EEG-Ach index was associated with hippocampal volume and cortical thickness in frontal, temporal, and occipital cortices. Cross-sectional sub-analyses based on a small sample suggests that the EEG-Ach index increases the closest to AD dementia, downstream to amyloid-beta pathology, CSF total tau, and hippocampal volume. We conclude that cholinergic dysfunction correlates with atrophy in brain areas important for AD pathogenesis, and this association is more prominent in the dementia stage. These results together with previous studies from this project suggest that the EEG-Ach index may be a useful biomarker for cholinergic dysfunction, with value for differential diagnosis of dementia and monitoring patients at the dementia stage. Keywords: Acetylcholine; Alzheimer's disease; Amyloid-beta; Dementia; Electroencephalography; Magnetic resonance imaging; Neurodegeneration.en_US
dc.description.sponsorshipKavli Charitable Trust in Bergen (Norway) NordForsk Velux Foundation (Denmark) Swedish Foundation for Strategic Research Foundation for Geriatric Diseases at Karolinska Institutet Gun och Bertil Stohnes Foundation Gamla Tjanarinnor Foundation Karolinska Institutet Dementia Funding in Swedenen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0925492720300718?via%3Dihuben_US
dc.rightsCopyright © 2020 Elsevier B.V. All rights reserved.
dc.subjectAcetylcholineen_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectAmyloid-betaen_US
dc.subjectDementiaen_US
dc.subjectElectroencephalographyen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectNeurodegenerationen_US
dc.subjectHrörnunarsjúkdómaren_US
dc.subjectHeilabilunen_US
dc.titleCholinergic dysfunction, neurodegeneration, and amyloid-beta pathology in neurodegenerative diseases.en_US
dc.typeArticleen_US
dc.typeOtheren_US
dc.identifier.eissn1872-7506
dc.contributor.department1Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. 2Geriatric Clinic, Landspitali University Hospital Landakot, Reykjavik, Iceland. 3Regional Dementia Research Center, Department of Neurology, Zealand University Hospital and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. 4Danish Dementia Research Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 5Department of Geriatric Medicine, Deaconess Hospital, Bergen, Norway. 6Norwegian Advisory Unit for Ageing and Health, Vestfold Hospital Trust and Oslo University Hospital, Oslo, Norway. 7Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. Electronic address: daniel.ferreira.padilla@ki.se.en_US
dc.identifier.journalPsychiatry research. Neuroimagingen_US
dc.rights.accessNational Consortium - Landsaðganguren_US
dc.departmentcodeGER12
dc.source.journaltitlePsychiatry research. Neuroimaging
dc.source.volume302
dc.source.beginpage111099
dc.source.endpage
dc.source.countryNetherlands


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