Disease duration, age at diagnosis and organ damage are important factors for cardiovascular disease in SLE.
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Ingvarsson, Ragnar Freyr
Bengtsson, Anders A
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CitationNived O, Ingvarsson RF, Jöud A, et al. Disease duration, age at diagnosis and organ damage are important factors for cardiovascular disease in SLE [published correction appears in Lupus Sci Med. 2020 Jul;7(1):. Ingvarsson, Ragnar Frey [corrected to Ingvarsson, Ragnar Freyr] and Tyden, Helena [corrected to Tydén, Helena]]. Lupus Sci Med. 2020;7(1):e000398. doi:10.1136/lupus-2020-000398
AbstractObjective: To report the incidence rate ratios (IRR) of acute myocardial infarctions (AMI) and cerebrovascular events (CVE) in incident SLE cases from a defined population. To study the risk factors for cardiovascular events in all patients with SLE at our unit. Methods: Patients with SLE diagnosed from 1981 to 2006 were followed through to 2016. IRRs of AMI and CVE were calculated. The AMI and CVE incidence patterns for patients with SLE were studied in relation to hypertension, smoking, renal dysfunction, anticardiolipin (aCL) antibodies at diagnosis, disease duration and organ damage before an event. Results: 262 patients with SLE were included in the study; of these 175 were from the defined population. Overall, 37 AMI and 44 CVE were recorded. An increased IRR of 3 for AMI was found (p<0.001). Smoking, hypertension and reduced renal function were risk factors for AMI. An increased IRR of 3.3 for ischaemic CVE was found for women (p<0.001). Hypertension and aCL were risk factors for CVE. Organ damage before events was increased. Conclusions: Cardiovascular events are increased in SLE and are associated with hypertension, smoking and increased damage rate. Keywords: cardiovascular diseases; epidemiology; lupus erythematosus, systemic.
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Rights© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
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