Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik study.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsSkuladottir, S S
Launer, L J
Cotch, M F
MetadataShow full item record
CitationSkuladottir SS, Ramel A, Hjaltadottir I, et al. Characteristics of incidence hip fracture cases in older adults participating in the longitudinal AGES-Reykjavik study [published online ahead of print, 2020 Aug 18]. Osteoporos Int. 2020;10.1007/s00198-020-05567-x. doi:10.1007/s00198-020-05567-x
AbstractPoor physical function and body composition my partly predict the risk of falls leading to fracture regardless of bone mineral density. Introduction: To examine the relationship between body composition, physical function, and other markers of health with hip fractures in older community-dwelling Icelandic adults. Methods: A prospective cohort of 4782 older adults from the AGES-Reykjavik study. Baseline recruitment took place between 2002 and 2006, and information on hip fractures occurring through 2012 was extracted from clinical records. Using multivariate regression analyses, baseline measures of bone health, physical function, and body composition were compared between those who later experienced hip fractures and to those who did not. Associations with the risk of fractures were quantified using Cox regression. Results: Mean age was 76.3 years at baseline. After adjustment for age, regression showed that male hip fracture cases compared with non-cases had (mean (95% confidence interval)) significantly lower thigh muscle cross-sectional area - 5.6 cm2 (- 10.2, - 1.1), poorer leg strength - 28 N (- 49, - 7), and decreased physical function as measured by longer timed up and go test 1.1 s (0.5, 1.7). After adjustment for age, female cases had, compared with non-cases, lower body mass index - 1.5 kg/m2 (- 2.1, - 0.9), less lean mass - 1.6 kg (- 2.5, - 0.8), thigh muscle cross-sectional area - 4.4 cm2 (- 6.5, - 2.3), and worse leg strength - 16 N (- 25, - 6). These differences largely persisted after further adjustment for bone mineral density (BMD), suggesting that body composition may contribute to the risk of fracture independent of bone health. When examining the association between these same factors and hip fractures using Cox regression, the same conclusions were reached. Conclusions: After accounting for age and BMD, older adults who later experienced a hip fracture had poorer baseline measures of physical function and/or body composition, which may at least partly contribute to the risk of falls leading to fracture. Keywords: Aging; Biomarkers; Body composition; Hip fracture; Physical function.
DescriptionUnited States Department of Health & Human Services National Institutes of Health (NIH) - USA National Institute on Aging Intramural Research Program, the National Eye Institute, USA ZIAEY000401 Hjartavernd (The Icelandic Heart Association) Althingi (Icelandic Parliament) St. Josef's Hospital Fund, Reykjavik, Iceland Landspitali University Hospital Research Fund Icelandic Gerontological Society Research Fund Helga Jonsdottir and Sigurlidi Kristjansson Geriatric Research Fund
- The timed up and go test predicts fracture risk in older women independently of clinical risk factors and bone mineral density.
- Authors: Larsson BAM, Johansson L, Johansson H, Axelsson KF, Harvey N, Vandenput L, Magnusson P, McCloskey E, Liu E, Kanis JA, Sundh D, Lorentzon M
- Issue date: 2021 Jan
- Accelerated decline in quadriceps area and Timed Up and Go test performance are associated with hip fracture risk in older adults with impaired kidney function.
- Authors: Marques EA, Elbejjani M, Viana JL, Gudnason V, Sigurdsson G, Lang T, Sigurdsson S, Aspelund T, Siggeirsdottir K, Launer L, Eiriksdottir G, Harris TB
- Issue date: 2021 Jul 1
- Lean mass and lower limb muscle function in relation to hip strength, geometry and fracture risk indices in community-dwelling older women.
- Authors: Elhakeem A, Hartley A, Luo Y, Goertzen AL, Hannam K, Clark EM, Leslie WD, Tobias JH
- Issue date: 2019 Jan
- Body size and hip fracture risk in older women: a prospective study. Study of Osteoporotic Fractures Research Group.
- Authors: Ensrud KE, Lipschutz RC, Cauley JA, Seeley D, Nevitt MC, Scott J, Orwoll ES, Genant HK, Cummings SR
- Issue date: 1997 Oct
- Associations of 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D With Bone Mineral Density, Bone Mineral Density Change, and Incident Nonvertebral Fracture.
- Authors: Swanson CM, Srikanth P, Lee CG, Cummings SR, Jans I, Cauley JA, Bouillon R, Vanderschueren D, Orwoll ES, Nielson CM, Osteoporotic Fractures in Men MrOS Study Research Group.
- Issue date: 2015 Aug