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Prevention of adverse drug reactions in hospitalized older patients with multi-morbidity and polypharmacy: the SENATOR* randomized controlled clinical trial.

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Authors
O'Mahony, Denis
Gudmundsson, Adalsteinn
Soiza, Roy L
Petrovic, Mirko
Jose Cruz-Jentoft, Alfonso
Cherubini, Antonio
Fordham, Richard
Byrne, Stephen
Dahly, Darren
Gallagher, Paul
Lavan, Amanda
Curtin, Denis
Dalton, Kieran
Cullinan, Shane
Flanagan, Evelyn
Shiely, Frances
Samuelsson, Olafur
Sverrisdottir, Astros
Subbarayan, Selvarani
Vandaele, Lore
Meireson, Eline
Montero-Errasquin, Beatriz
Rexach-Cano, Aurora
Correa Perez, Andrea
Lozano-Montoya, Isabel
Vélez-Díaz-Pallarés, Manuel
Cerenzia, Annarita
Corradi, Samanta
Soledad Cotorruelo Ferreiro, Maria
Dimitri, Federica
Marinelli, Paolo
Martelli, Gaia
Fong Soe Khioe, Rebekah
Eustace, Joseph
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Issue Date
2020-07

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O'Mahony D, Gudmundsson A, Soiza RL, Petrovic M, Jose Cruz-Jentoft A, Cherubini A, Fordham R, Byrne S, Dahly D, Gallagher P, Lavan A, Curtin D, Dalton K, Cullinan S, Flanagan E, Shiely F, Samuelsson O, Sverrisdottir A, Subbarayan S, Vandaele L, Meireson E, Montero-Errasquin B, Rexach-Cano A, Correa Perez A, Lozano-Montoya I, Vélez-Díaz-Pallarés M, Cerenzia A, Corradi S, Soledad Cotorruelo Ferreiro M, Dimitri F, Marinelli P, Martelli G, Fong Soe Khioe R, Eustace J. Prevention of adverse drug reactions in hospitalized older patients with multi-morbidity and polypharmacy: the SENATOR* randomized controlled clinical trial. Age Ageing. 2020 Jul 1;49(4):605-614. doi: 10.1093/ageing/afaa072. PMID: 32484850.
Abstract
Background: Multi-morbidity and polypharmacy increase the risk of non-trivial adverse drug reactions (ADRs) in older people during hospitalization. Despite this, there are no established interventions for hospital-acquired ADR prevention. Methods: We undertook a pragmatic, multi-national, parallel arm prospective randomized open-label, blinded endpoint (PROBE) controlled trial enrolling patients at six European medical centres. We randomized 1,537 older medical and surgical patients with multi-morbidity and polypharmacy on admission in a 1:1 ratio to SENATOR software-guided medication optimization plus standard care (intervention, n = 772, mean number of daily medications = 9.34) or standard care alone (control, n = 765, mean number of daily medications = 9.23) using block randomization stratified by site and admission type. Attending clinicians in the intervention arm received SENATOR-generated advice at a single time point with recommendations they could choose to adopt or not. The primary endpoint was occurrence of probable or certain ADRs within 14 days of randomization. Secondary endpoints were primary endpoint derivatives; tertiary endpoints included all-cause mortality, re-hospitalization, composite healthcare utilization and health-related quality of life. Results: For the primary endpoint, there was no difference between the intervention and control groups (24.5 vs. 24.8%; OR 0.98; 95% CI 0.77-1.24; P = 0.88). Similarly, with secondary and tertiary endpoints, there were no significant differences. Among attending clinicians in the intervention group, implementation of SENATOR software-generated medication advice points was poor (~15%). Conclusions: In this trial, uptake of software-generated medication advice to minimize ADRs was poor and did not reduce ADR incidence during index hospitalization. Keywords: STOPP/START criteria; adverse drug reactions; multi-morbidity; older people; polypharmacy; prevention; software.
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Additional Links
https://academic.oup.com/ageing/article/49/4/605/5827768
Rights
© The Author(s) 2020. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com.
ae974a485f413a2113503eed53cd6c53
10.1093/ageing/afaa072
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