Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
Mogensen, Pernille Rudebeck
Jonsson, Ólafur G
MetadataShow full item record
CitationEgnell C, Ranta S, Banerjee J, Merker A, Niinimäki R, Lund B, Mogensen PR, Jonsson ÓG, Vaitkeviciene G, Lepik K, Forslund A, Heyman M, Harila-Saari A. Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols. Eur J Haematol. 2020 Dec;105(6):797-807. doi: 10.1111/ejh.13517
AbstractObjectives: High body mass index (BMI) is associated with poorer survival in childhood acute lymphoblastic leukemia (ALL), but the actual impact on the risk of relapse still needs to be clarified. We evaluated the impact of BMI at diagnosis on the risk of relapse in children with ALL treated according to Nordic Society of Paediatric Haematology and Oncology (NOPHO) protocols. Method: In a multicenter study, we collected data on BMI at diagnosis and outcome of 2558 children aged 2.0-17.9 years diagnosed between 1992 and 2016. Patients were divided into four groups according to International Obesity Task Force (IOTF) childhood BMI cut-offs: underweight, <17; healthy weight, 17-25; overweight, 25-30; and obese, ≥30 kg/m2 . Results: In Cox multivariate regression analyses, an increased risk of relapse was observed in children aged 10-17.9 years with unhealthy BMI at diagnosis (underweight hazard ratio HR: 2.90 [95% confidence interval: 1.24-6.78], P = .01; overweight, HR: 1.95 [1.11-3.43], P = .02, and obese HR: 4.32 [95% 2.08-8.97], P < .001), compared to children with healthy weight. BMI had no impact on relapse in children under 10 years of age. Conclusion: High BMI, and especially obesity at diagnosis, is an independent adverse prognostic factor for relapse in older children with ALL. Keywords: acute lymphoblastic leukemia; body mass index; children; obesity; survival.
DescriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
Rights© 2020 The Authors. European Journal of Haematology published by John Wiley & Sons Ltd.
- Obesity and dental caries in paediatric patients. A cross-sectional study.
- Authors: Costacurta M, Di Renzo L, Bianchi A, Fabiocchi F, De Lorenzo A, Docimo R
- Issue date: 2011 Jun
- The effectiveness of web-based programs on the reduction of childhood obesity in school-aged children: A systematic review.
- Authors: Antwi F, Fazylova N, Garcon MC, Lopez L, Rubiano R, Slyer JT
- Issue date: 2012
- The negative impact of being underweight and weight loss on survival of children with acute lymphoblastic leukemia.
- Authors: den Hoed MA, Pluijm SM, de Groot-Kruseman HA, te Winkel ML, Fiocco M, van den Akker EL, Hoogerbrugge P, van den Berg H, Leeuw JA, Bruin MC, Bresters D, Veerman AJ, Pieters R, van den Heuvel-Eibrink MM
- Issue date: 2015 Jan
- [Body mass index and cancer incidence:a prospective cohort study in northern China].
- Authors: Guo L, Li N, Wang G, Su K, Li F, Yang L, Ren J, Chang S, Chen S, Wu S, He J, Dai M
- Issue date: 2014 Mar
- Prospective study of thromboembolism in 1038 children with acute lymphoblastic leukemia: a Nordic Society of Pediatric Hematology and Oncology (NOPHO) study.
- Authors: Tuckuviene R, Ranta S, Albertsen BK, Andersson NG, Bendtsen MD, Frisk T, Gunnes MW, Helgestad J, Heyman MM, Jonsson OG, Mäkipernaa A, Pruunsild K, Tedgård U, Trakymiene SS, Ruud E
- Issue date: 2016 Mar