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dc.contributor.authorLyons, Sarah A
dc.contributor.authorKnulst, André C
dc.contributor.authorBurney, Peter G J
dc.contributor.authorFernandez-Rivas, Montserrat
dc.contributor.authorBallmer-Weber, Barbara K
dc.contributor.authorBarreales, Laura
dc.contributor.authorBieli, Christian
dc.contributor.authorClausen, Michael
dc.contributor.authorDubakiene, Ruta
dc.contributor.authorFernandez-Perez, Cristina
dc.contributor.authorJedrzejczak-Czechowicz, Monika
dc.contributor.authorKowalski, Marek L
dc.contributor.authorKummeling, Ischa
dc.contributor.authorKralimarkova, Tanya
dc.contributor.authorMustakov, Tihomir B
dc.contributor.authorvan Os-Medendorp, Harmieke
dc.contributor.authorPapadopoulos, Nikolaos G
dc.contributor.authorPopov, Todor A
dc.contributor.authorPotts, James
dc.contributor.authorVersteeg, Serge A
dc.contributor.authorXepapadaki, Paraskevi
dc.contributor.authorWelsing, Paco M J
dc.contributor.authorMills, Clare
dc.contributor.authorvan Ree, Ronald
dc.contributor.authorLe, Thuy-My
dc.date.accessioned2020-11-20T13:55:56Z
dc.date.available2020-11-20T13:55:56Z
dc.date.issued2020-09-07
dc.date.submitted2020-11
dc.identifier.citationLyons SA, Knulst AC, Burney PGJ, Fernandez-Rivas M, Ballmer-Weber BK, Barreales L, et al. Predicting food allergy: The value of patient history reinforced. Allergy. 2020 Sep 7. doi: 10.1111/all.14583. Epub ahead of print. PMID: 32894581.en_US
dc.identifier.pmid32894581
dc.identifier.doi10.1111/all.14583
dc.identifier.urihttp://hdl.handle.net/2336/621571
dc.description.abstractBackground: EAACI guidelines emphasize the importance of patient history in diagnosing food allergy (FA) and the need for studies investigating its value using standardized allergy-focused questionnaires. Objective: To determine the contribution of reaction characteristics, allergic comorbidities and demographics to prediction of FA in individuals experiencing food-related adverse reactions. Methods: Adult and school-age participants in the standardized EuroPrevall population surveys, with self-reported FA, were included. Penalized multivariable regression was used to assess the association of patient history determinants with "probable" FA, defined as a food-specific case history supported by relevant IgE sensitization. Results: In adults (N = 844), reproducibility of reaction (OR 1.35 [95% CI 1.29-1.41]), oral allergy symptoms (OAS) (4.46 [4.19-4.75]), allergic rhinitis (AR) comorbidity (2.82 [2.68-2.95]), asthma comorbidity (1.38 [1.30-1.46]) and male sex (1.50 [1.41-1.59]) were positively associated with probable FA. Gastrointestinal symptoms (0.88 [0.85-0.91]) made probable FA less likely. The AUC of a model combining all selected predictors was 0.85 after cross-validation. In children (N = 670), OAS (2.26 [2.09-2.44]) and AR comorbidity (1.47 [CI 1.39-1.55]) contributed most to prediction of probable FA, with a combined cross-validation-based AUC of 0.73. When focusing on plant foods, the dominant source of FA in adults, the pediatric model also included gastrointestinal symptoms (inverse association), and the AUC increased to 0.81. Conclusions: In both adults and school-age children from the general population, reporting of OAS and of AR comorbidity appear to be the strongest predictors of probable FA. Patient history particularly allows for good discrimination between presence and absence of probable plant FA. Keywords: Europe; food allergy; food sensitization; patient history; prediction.en_US
dc.description.sponsorshipEuropean Union (EU)en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/10.1111/all.14583en_US
dc.rights© 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
dc.subjectEuropeen_US
dc.subjectfood allergyen_US
dc.subjectfood sensitizationen_US
dc.subjectpatient historyen_US
dc.subjectpredictionen_US
dc.subjectFæðuofnæmien_US
dc.subjectHeilsufarsupplýsingaren_US
dc.subjectSjúkdómsgreiningen_US
dc.subject.meshFood Hypersensitivityen_US
dc.subject.meshDiagnosisen_US
dc.titlePredicting food allergy: The value of patient history reinforced.en_US
dc.typeArticleen_US
dc.identifier.eissn1398-9995
dc.contributor.department1Department of Dermatology and Allergology, University Medical Center Utrecht, Utrecht, The Netherlands. 2National Heart and Lung Institute, Imperial College London, London, UK. 3Allergy Department, Hospital Clinico San Carlos, IdISSC, ARADyAL, RD16/0006/0009, Madrid, Spain. 4Allergy Unit, Department of Dermatology, University Hospital of Zürich, Zürich, Switzerland. 5Faculty of Medicine, University of Zürich, Zürich, Switzerland. 6Clinic for Dermatology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland. 7Clinical Epidemiology Unit, Preventive Medicine Department, Hospital Clinico San Carlos, IdISSC, Madrid, Spain. 8Department of Paediatric Pulmonology, University Children's Hospital, Zürich, Switzerland. 9Children's Hospital, Landspitali University Hospital, Reykjavik, Iceland. 10Medical Faculty, Vilnius University, Vilnius, Lithuania. 11Department of Immunology, Rheumatology and Allergy, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. 12Clinical Centre of Allergology of the Alexandrovska Hospital, Medical University of Sofia, Sofia, Bulgaria. 13Saxion University of Applied Sciences, Deventer, The Netherlands. 14Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece. 15Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK. 16University Hospital Sv. Ivan Rilski, Sofia, Bulgaria. 17Department of Experimental Immunology, Amsterdam University Medical Center, Amsterdam, The Netherlands. 18Division of Internal Medicine and Dermatology, University Medical Center Utrecht, Utrecht University, The Netherlands. 19Division of Infection, Immunity and Respiratory Medicine, Manchester Institute of Biotechnology & Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK. 20Department of Otorhinolaryngology, Amsterdam University Medical Center, Amsterdam, The Netherlands.en_US
dc.identifier.journalAllergyen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodePED12
dc.source.journaltitleAllergy
refterms.dateFOA2020-11-20T13:55:57Z
dc.source.countryDenmark


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