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dc.contributor.authorBjarnason, Thorarinn A
dc.contributor.authorHafthorsson, Steinar O
dc.contributor.authorKristinsdottir, Linda B
dc.contributor.authorOskarsdottir, Erna S
dc.contributor.authorJohnsen, Arni
dc.contributor.authorAndersen, Karl
dc.date.accessioned2020-12-14T10:13:18Z
dc.date.available2020-12-14T10:13:18Z
dc.date.issued2019-05-20
dc.date.submitted2020-12
dc.identifier.citationBjarnason TA, Hafthorsson SO, Kristinsdottir LB, Oskarsdottir ES, Johnsen A, Andersen K. The prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome. Eur Heart J Acute Cardiovasc Care. 2020 Sep;9(6):608-615. doi: 10.1177/2048872619849925.en_US
dc.identifier.pmid31107107
dc.identifier.doi10.1177/2048872619849925
dc.identifier.urihttp://hdl.handle.net/2336/621600
dc.descriptionTo access publisher's full text version of this article click on the hyperlink belowen_US
dc.description.abstractBackground: Dysglycemia is a well-established risk factor of coronary artery disease. Less is known of the prognostic effect of dysglycemia in acute coronary syndromes (ACSs). The aim of this study was to evaluate the long-term outcome of patients with ACSs according to glucometabolic categories. Methods: Patients with ACSs were consecutively included in the study. Among those with no previous history of type 2 diabetes (T2DM) glucose metabolism was evaluated with fasting glucose in plasma, glycated hemoglobin and a standard 2-h oral glucose tolerance test. Patients were classified having normal glucose metabolism, prediabetes, newly detected T2DM (nT2DM) and previously known T2DM (kT2DM). The clinical outcome parameters were death or myocardial infarction and other major adverse cardiac events (MACEs). Results: A total of 372 ACS patients (male 75.8%, 65.1 years (SD: 11.8)) constituted the study population. The proportion diagnosed with normal glucose metabolism, prediabetes, nT2DM and kT2DM was 20.7%, 46.5%, 6.2% and 26.6%, respectively. The mean follow-up period was 2.9 years. Patients with prediabetes, nT2DM and kT2DM had a hazard ratio of 5.8 (95% confidence interval (CI) 0.8-44.6), 10.9 (95% CI 1.2-98.3) and 14.9 (95% CI 2.0-113.7), respectively, for death/myocardial infarction and 1.4 (95% CI 0.6-3.1), 2.9 (95% CI 1.1-8.0) and 3.3 (95% CI 1.5-7.6), respectively, for a composite of MACEs. Conclusion: Patients with ACS and nT2DM or kT2DM were at increased risk of death/myocardial infarction and MACE compared with patients with normal glucose metabolism after approximately three years of follow-up. Keywords: Acute coronary syndrome; prognosis; survival; type 2 diabetes.en_US
dc.description.sponsorshipUniversity of Iceland Research Fund Landspitali University Hospital Research Fund Icelandic Society of Cardiology Research Funden_US
dc.language.isoenen_US
dc.publisherSAGE Publicationsen_US
dc.relation.urlhttps://journals.sagepub.com/doi/10.1177/2048872619849925en_US
dc.subjectAcute coronary syndromeen_US
dc.subjectprognosisen_US
dc.subjectsurvivalen_US
dc.subjecttype 2 diabetesen_US
dc.subjectKransæðasjúkdómaren_US
dc.subjectSykursýkien_US
dc.subject.meshAcute Coronary Syndromeen_US
dc.subject.meshDiabetes Mellitus, Type 2en_US
dc.titleThe prognostic effect of known and newly detected type 2 diabetes in patients with acute coronary syndrome.en_US
dc.typeArticleen_US
dc.identifier.eissn2048-8734
dc.contributor.department1Department of Internal Medicine, University of Iowa Hospital and Clinics, Iowa City, USA. 2University of Iceland, School of Health Sciences, Reykjavik, Iceland. 3Department of Medicine, Division of Cardiology, Landspitali the National University Hospital of Iceland, Reykjavik, Iceland.en_US
dc.identifier.journalEuropean heart journal. Acute cardiovascular careen_US
dc.rights.accessOpen Access - Opinn aðganguren_US
dc.departmentcodeCAR12
dc.source.journaltitleEuropean heart journal. Acute cardiovascular care
dc.source.volume9
dc.source.issue6
dc.source.beginpage608
dc.source.endpage615
dc.source.countryEngland


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