Predictors of Food Sensitization in Children and Adults Across Europe.
Cast your vote
You can rate an item by clicking the amount of stars they wish to award to this item.
When enough users have cast their vote on this item, the average rating will also be shown.
Your vote was cast
Thank you for your feedback
Thank you for your feedback
AuthorsLyons, Sarah A
Knulst, André C
Burney, Peter G J
Ballmer-Weber, Barbara K
Kowalski, Marek L
Mustakov, Tihomir B
van Os-Medendorp, Harmieke
Papadopoulos, Nikolaos G
Popov, Todor A
Welsing, Paco M J
Mills, E N Clare
van Ree, Ronald
MetadataShow full item record
CitationLyons SA, Knulst AC, Burney PGJ, Fernández-Rivas M, Ballmer-Weber BK, Barreales L, et al. Predictors of Food Sensitization in Children and Adults Across Europe. The journal of allergy and clinical immunology In practice. 2020;8(9):3074-83.e32.doi:10.1016/j.jaip.2020.04.040.
AbstractBackground: The geographical variation and temporal increase in the prevalence of food sensitization (FS) suggest environmental influences. Objective: To investigate how environment, infant diet, and demographic characteristics, are associated with FS in children and adults, focusing on early-life exposures. Methods: Data on childhood and adult environmental exposures (including, among others, sibship size, day care, pets, farm environment, and smoking), infant diet (including breast-feeding and timing of introduction to infant formula and solids), and demographic characteristics were collected from 2196 school-age children and 2185 adults completing an extensive questionnaire and blood sampling in the cross-sectional pan-European EuroPrevall project. Multivariable logistic regression was applied to determine associations between the predictor variables and sensitization to foods commonly implicated in food allergy (specific IgE ≥0.35 kUA/L). Secondary outcomes were inhalant sensitization and primary (non-cross-reactive) FS. Results: Dog ownership in early childhood was inversely associated with childhood FS (odds ratio, 0.65; 95% CI, 0.48-0.90), as was higher gestational age at delivery (odds ratio, 0.93 [95% CI, 0.87-0.99] per week increase in age). Lower age and male sex were associated with a higher prevalence of adult FS (odds ratio, 0.97 [95% CI, 0.96-0.98] per year increase in age, and 1.39 [95% CI, 1.12-1.71] for male sex). No statistically significant associations were found between other evaluated environmental determinants and childhood or adult FS, nor between infant diet and childhood FS, although early introduction of solids did show a trend toward prevention of FS. Conclusions: Dog ownership seems to protect against childhood FS, but independent effects of other currently conceived environmental and infant dietary determinants on FS in childhood or adulthood could not be confirmed. Keywords: Dog; Early-life exposures; Environment; Europe; Food allergy; Food sensitization; Infant diet; Inhalant sensitization; Predictors; Risk factors.
DescriptionTo access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
RightsCopyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
- Prevalence of Food Sensitization and Food Allergy in Children Across Europe.
- Authors: Lyons SA, Clausen M, Knulst AC, Ballmer-Weber BK, Fernandez-Rivas M, Barreales L, Bieli C, Dubakiene R, Fernandez-Perez C, Jedrzejczak-Czechowicz M, Kowalski ML, Kralimarkova T, Kummeling I, Mustakov TB, Papadopoulos NG, Popov TA, Xepapadaki P, Welsing PMJ, Potts J, Mills ENC, van Ree R, Burney PGJ, Le TM
- Issue date: 2020 Sep
- Introduction of complementary foods in infancy and atopic sensitization at the age of 5 years: timing and food diversity in a Finnish birth cohort.
- Authors: Nwaru BI, Takkinen HM, Niemelä O, Kaila M, Erkkola M, Ahonen S, Tuomi H, Haapala AM, Kenward MG, Pekkanen J, Lahesmaa R, Kere J, Simell O, Veijola R, Ilonen J, Hyöty H, Knip M, Virtanen SM
- Issue date: 2013 Apr
- Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention.
- Authors: Halken S
- Issue date: 2004 Jun
- Timing of solid food introduction in relation to eczema, asthma, allergic rhinitis, and food and inhalant sensitization at the age of 6 years: results from the prospective birth cohort study LISA.
- Authors: Zutavern A, Brockow I, Schaaf B, von Berg A, Diez U, Borte M, Kraemer U, Herbarth O, Behrendt H, Wichmann HE, Heinrich J, LISA Study Group.
- Issue date: 2008 Jan
- Gene polymorphisms, breast-feeding, and development of food sensitization in early childhood.
- Authors: Hong X, Wang G, Liu X, Kumar R, Tsai HJ, Arguelles L, Hao K, Pearson C, Ortiz K, Bonzagni A, Apollon S, Fu L, Caruso D, Pongracic JA, Schleimer R, Holt PG, Bauchner H, Wang X
- Issue date: 2011 Aug